DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP1 and arr

DIOPT Version :9

Sequence 1:	XP_016874792.1	Gene:	LRP1 / 4035	HGNCID:	6692	Length:	4561	Species:	Homo sapiens
Sequence 2:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster

Alignment Length:	1676	Identity:	483/1676 - (28%)
Similarity:	759/1676 - (45%)	Gaps:	297/1676 - (17%)

- Green bases have known domain annotations that are detailed below.

Human  1230 ELGPDNHTCQI----QSYCAKHLKCSQKCD-----QNKFSVKCSCY---EGW----VLEPDGESC 1278
            |:.|  ..||:    :....|..||::...     |........|:   ..|    |..|...|.
  Fly    11 EIEP--QLCQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNVHMPSSSSL 73

Human  1279 RSLDPFKPFI------IFSNRHEIRRIDLHK----GDYSVLVPGLRNTIALDFHLSQSALYWTD- 1332
            .:..|...|:      :|:.||:|:..::.:    ....|:|..|...:|:||:.:::.:.|||
  Fly    74 IASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDS 138

Human  1333 ---VVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTL 1394
               ::|........|........:.||..||..|||||:||....|||.:...::||||.|||..
  Fly   139 GREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRY 203

Human  1395 RTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSG--AGRRTVHRETGSGGWPNGLT 1457
            :..|...|::.|||:|:.|...:|.|||| ...|:||.|||.|  ..|.|:.:|  ...|||||.
  Fly   204 QKVLFWTDLDQPRAVAVVPARKLLIWTDW-GEYPKIERASMDGDPLSRMTLVKE--HVFWPNGLA 265

Human  1458 VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKAN 1522
            ||...:.|.|.|.:...|...|.|||....::..   |.:||::|.|...:|||||:..:|...:
  Fly   266 VDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVNN---LKYPFSLTFYDDRLYWTDWQRGSLNALD 327

Human  1523 KWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYN-RTVSCACPHLM 1586
            ..|.....::. |...|..::.:.||.||...|||..|.|.  ||||||:..| :..|||||..:
  Fly   328 LQTRELKELID-TPKAPNSVRAWDPSLQPYEDNPCAHNNGN--CSHLCLLATNSQGFSCACPTGV 389

Human  1587 KLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDV 1651
            ||...||.....::.:...::.:|..:.||:|.|. |....:..:.....:|||..|:.:|||||
  Fly   390 KLISANTCANGSQEMMFIVQRTQISKISLDSPDYT-IFPLPLGKVKYAIAIDYDPVEEHIYWSDV 453

Human  1652 RTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV- 1715
            .|..||||..:||||...|::::.:..|||:||::|||:||  ||...:|.|.||||:.:..::
  Fly   454 ETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWT--DTVTDRIEVCRLDGTARKVLIY 516

Human  1716 QGLEQPHGLVVHPLRGKLYWTDGD----NISMANMDGSNRTLLFSGQKG-PVGLAIDFPESKLYW 1775
            :.||:|..:.|.|..|.::|:|.:    .:..|::|||.|.:|.|...| |.|:|:|.....:||
  Fly   517 EHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYW 581

Human  1776 ISSGNHTINRCNLDGSGLEVI--DAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSV 1838
            .......|...|:||||..|:  |.::...|    |:|:.|.|:|.|.....:....|..|:..:
  Fly   582 CDGKTDKIEVANMDGSGRRVVISDNLKHLFG----LSILDDYLYWTDWQRRSIDRAHKITGNNRI 642

Human  1839 VLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCL--PTSETTRSCMCTAGYSLRSGQQ 1901
            |:.:....:|.:||   :...:.:|.|.|:|.||.||.|||  |....   |.|...|.|.:.::
  Fly   643 VVVDQYPDLMGLKV---TRLREVRGQNACAVRNGGCSHLCLNRPRDYV---CRCAIDYELANDKR 701

Human  1902 ACEGVGSFLLYSVHEGIRGIPLDPND--KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTIS 1964
            .|....:|||:|..|.|..|.::.|:  .:|..:|......|..:|.......|||.|.....|.
  Fly   702 TCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIF 766

Human  1965 RAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRA 2029
            ||..:.::.:.:|.:|:...:||||||:|.||||:|.....||||||:||.|.|::.:|:::||:
  Fly   767 RAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRS 831

Human  2030 ITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWC-DARTDKI 2093
            :.:.|.:||::||| .....|.|:.:||::...:| ...:...|::.|.:..:|||. .:|..||
  Fly   832 LVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAKI 894

Human  2094 ERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQ 2158
            |..|.: |:.|::::.|:..:.::||:::|::||||..  .|.|:|..|....:...:.:|: ..
  Fly   895 ESADWD-GKKRQILVGSDMDEPYAVSLYQDYVYWSDWN--TGDIERVHKTTGQNRSLVHSGM-TY 955

Human  2159 LKDIKVFNRDRQKGTNVCAVANGGCQQLCLYR-GRGQRACAC-AHGMLAEDGASCREYAGYLLYS 2221
            :..:.|||..||.|.|.|.|.||||..|||.: ||....||| .|..||:||.||.....|:::|
  Fly   956 ITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFS 1020

Human  2222 ERTILKSI--HLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQ 2284
            :|.....:  :.:|..|:..||..       ||:.|:.:|      |.| :.|::.:....:|::
  Fly  1021 QRNCFGRLLPNTTDCPNIPLPVSG-------KNIRAVDYD------PIT-HHIYWIEGRSHSIKR 1071

Human  2285 INDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETV-ITMSGD 2348
            ...:|: :::::.|.|....||.......|:||...:::|        ...:|..|:| :..:||
  Fly  1072 SLANGT-KVSLLANSGQPFDLAIDIIGRLLFWTCSQSNSI--------NVTSFLGESVGVIDTGD 1127

Human  2349 -DHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSD 2412
             :.||...:...:.|:|||:.. .|.:|:||.:.|...:.|..| :.....||:|.:::.:|::.
  Fly  1128 SEKPRNIAVHAMKRLLFWTDVG-SHQAIIRARVDGNERVELAYK-LEGVTALALDQQSDMIYYAH 1190

Human  2413 ATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI 2477
            .  .:|:..:.:|.::..::.........:|..|..::|.| .:..|:|
  Fly  1191 G--KRIDAIDINGKNKKTLVSMHISQVINIAALGGFVYWLD-DKTGVER---------------- 1236

Human  2478 PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCR 2542
                   |.|..:..|.||          |.|..:|                 |:  |||
  Fly  1237 -------ITVNGERRSAEL----------QRLPQIT-----------------DI--RAV----- 1260

Human  2543 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADD 2607
                            .|.|            |....:..|..:..:||: .|:
  Fly  1261 ----------------WTPD------------PKVLRNHTCMHSRTKCSH-ICI----------- 1285

Human  2608 CGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGV 2672
                         |.|.|..|.||                       .||   |..:..|
  Fly  1286 -------------ASGEGIARTRD-----------------------VCS---CPKHLML----- 1306

Human  2673 LFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACP---SG------RCIPM 2728
                             .:...:||.:           |.|..::|.|.   ||      .|||.
  Fly  1307 -----------------LEDKENCGAF-----------PACGPDHFTCAAPVSGISDVNKDCIPA 1343

Human  2729 SWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGP 2793
            ||.||.:.||....||..| ..|...||.||:..||.|..:|||:.:|.:|.|||..|:    .|
  Fly  1344 SWRCDGQKDCPDKSDEVGC-PTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADCCK----RP 1403

Human  2794 SSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYN---STCDDREFM 2841
            ..|.||...:|:....||||.::|||||||| :..||..   ...|.|.||
  Fly  1404 GEFQCPINKLCISAALLCDGWENCADGADES-SDICLQRRMAPATDKRAFM 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP1	XP_016874792.1	None
arr	NP_524737.2	LY	162..201	CDD:214531	19/38 (50%)
		NHL	168..503	CDD:302697	133/346 (38%)
		NHL repeat	172..237	CDD:271320	29/65 (45%)
		LY	252..293	CDD:214531	17/42 (40%)
		NHL repeat	261..298	CDD:271320	14/36 (39%)
		NHL repeat	303..339	CDD:271320	11/36 (31%)
		NHL repeat	341..419	CDD:271320	27/79 (34%)
		NHL repeat	428..476	CDD:271320	19/47 (40%)
		LY	472..511	CDD:214531	19/40 (48%)
		NHL repeat	477..503	CDD:271320	13/27 (48%)
		Ldl_recept_b	534..573	CDD:278487	13/38 (34%)
		LY	558..599	CDD:214531	14/40 (35%)
		LY	600..641	CDD:214531	11/44 (25%)
		FXa_inhibition	668..703	CDD:291342	14/37 (38%)
		LY	739..773	CDD:214531	9/33 (27%)
		LY	776..818	CDD:214531	22/41 (54%)
		LY	819..860	CDD:214531	14/41 (34%)
		FXa_inhibition	973..1010	CDD:291342	19/36 (53%)
		LY	1122..1164	CDD:214531	13/42 (31%)
		FXa_inhibition	1273..1313	CDD:291342	14/112 (13%)
		LDLa	1319..1362	CDD:238060	16/42 (38%)
		LDLa	1365..1399	CDD:238060	16/33 (48%)
		LDLa	1399..1433	CDD:197566	15/37 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155336
Domainoid	1	1.000	56	1.000	Domainoid score	I11002
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.640