DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and CG32432

DIOPT Version :10

Sequence 1:NP_002323.2 Gene:LRP1 / 4035 HGNCID:6692 Length:4544 Species:Homo sapiens
Sequence 2:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster


Alignment Length:1559 Identity:282/1559 - (18%)
Similarity:426/1559 - (27%) Gaps:658/1559 - (42%)


- Green bases have known domain annotations that are detailed below.


Human  1142 SLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVC 1206
            |..|......|:|..  |:|..|.|:..:||||||||...|.:|:....|               
  Fly   211 STGCSLAEFSCSNGR--CVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYG--------------- 258

Human  1207 SCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFI 1271
                  ::|        |:|.                                            
  Fly   259 ------DIG--------QTYA-------------------------------------------- 265

Human  1272 IFSNRHEIRRIDLH--KGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTS 1334
                      ::||  |.|....|..|..|.|...|        .|||:      ..||:..:..
  Fly   266 ----------LELHRPKQDRVPFVCVLTFTAAGGQH--------GDVVQ------VTLDSFTIGR 306

Human  1335 FEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDG 1399
            |...:..|  .|:|                  .:::|:   :.||                |..|
  Fly   307 FTSYVHEG--CPDG------------------YMQIAE---SART----------------PIGG 332

Human  1400 ILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYD 1464
            :...:.|                               |..:.|.|.|.|....|.:.:  || |
  Fly   333 MWCGSSW-------------------------------GPVLFYSETRSLIFTIRLNRL--AR-D 363

Human  1465 GSGHMEVLR-GHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVY 1528
            .||:....| .::.||...:||.|||         ..||:..:|  ||.:.......|....|..
  Fly   364 QSGYNFDFRIRYKVLSRDSSVTRYGG---------IKLAELAQW--HNRSSFLNQQQQQQQQQQQ 417

Human  1529 HPSRQPMAPNPCEANGGQGPCSHLCLINY-NRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQME 1592
            ...:|..||...|              :: |.:|:          :.:....:|..|..||.   
  Fly   418 QQQQQQGAPGILE--------------DFTNSSVA----------RSDRYGQDFSLFSAYAN--- 455

Human  1593 IRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVS--- 1654
                  :..:...:......|..|.|       |.:.|..|:         |.||....:.|   
  Fly   456 ------NKTFMASLEKSLAKDEQNYT-------EPKYYLGDL---------IPGTYCSRIFSDCD 498

Human  1655 -----ADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHG-----LVV 1709
                 ...||..|:    ..|||  |.|                  ..|:..:.|||     ||.
  Fly   499 KKPCRLQSPNFPGI----YPRNL--TCY------------------YAVRQHDVPHGKHALILVK 539

Human  1710 HPLRGKLYWTDGDNISMANM-----DGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRC 1769
            .| :|.|.|......:.||.     ..|::...|.            |..|         |.|.|
  Fly   540 QP-KGNLVWISTQETAAANKMAPPPSASDKDKKFE------------PRLK---------TWNYC 582

Human  1770 NLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVV---LRNSTTLVM 1831
                   :.|........|:|....:.|.....|.:..|.  |    |.|..|   :.:...|::
  Fly   583 -------DYIQENVKPKWKSTDYVTVYDGYTTRDPIILKF--C----GGGQAVPAAVSSGPELLV 634

Human  1832 HMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLR--------------SG 1882
            ..            .|:|.....|..||: ||          ..|:.|.              ..
  Fly   635 EF------------STSPFGTFTGTSSQV-LP----------LYGFQLEVEVQFVDIQSPTYSKN 676

Human  1883 QQACEGVGSFLLYSVHEGIRGIP---LDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS 1944
            ::.||    |.:.....||...|   |.||  |..|..:.|..:....|.         :.:...
  Fly   677 KKPCE----FWIRGAGRGILESPKHSLAPN--STCLYHLQGLGVFKTFDH---------LSLSRR 726

Human  1945 TISRA------KRDQTWREDVVTN---GIGRVEGIAVDWIAGNIYWTDQGFDVIEVARL-NGSFR 1999
            |.|::      .|.:.|...:..|   ..|:::..:|..|  .:..|.:  |...:.|: :|:.|
  Fly   727 TSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAI--GVLQTQE--DCSGMLRIWDGTLR 787

Human  2000 YVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDG 2064
            ...:.:.|:.....:.:...|:..........|..|..:..|.....:|.:.:.|..||..|   
  Fly   788 DAPVCKDLNCATETSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESY--- 849

Human  2065 KLYWCDARTDKIERIDLETGENREVVLSSNNMDM---FSVSVFEDFIYWSDRTH-ANGSIKRGSK 2125
                    ....:.|.||.......||...:..:   | :.:.:|.:.|....| .|........
  Fly   850 --------VSTSDAITLELRNTESTVLRPLDFKLKYEF-IDLHQDGLPWGGGEHDCNRKFLSSMM 905

Human  2126 DNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQL-CLYRGRGQRACACAHGM--L 2187
            |.               ||..:|...|    |:.....||.:.| |:|:...||.......|  :
  Fly   906 DR---------------KDPAIFRSVR----NIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKV 951

Human  2188 AEDGASCREYAGYLLYS--ERTILKSIHLSDERNLNAPVQPFEDPEH------------MKNVIA 2238
            ......|        ||  :..|.:|....|   .|..::.||.|.|            ..|...
  Fly   952 TTTNRPC--------YSRVDEDINRSFCYGD---TNVRIEIFERPYHDSILLHRGCMCNSSNQSH 1005

Human  2239 LAFDYRAGTSPGTPNRIFFSDIHF--GNIQQIND--------------------DGSRRI----T 2277
            |..:| ..||...       ::||  .|:..::|                    ||.|:.    |
  Fly  1006 LPVEY-TSTSRDV-------EVHFIAQNMTTLDDPDTVNFEGMFEFVKAPTSCKDGRRKFGPSGT 1062

Human  2278 IVENVGSVE------------------------GLAYHRGWDTLYWTSYTTSTITRHTVDQTRPG 2318
            |....|.||                        .|:.|....||..|...|.|....|..:....
  Fly  1063 IDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSRAVLT 1127

Human  2319 AFERETVIT--MSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNG 2381
            ..|..|::.  :|.|.:...||      .:|.:.|||:                        || 
  Fly  1128 TSEGLTIVACPLSPDSNAYEFV------EIFSSGWNER------------------------PN- 1161

Human  2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRAN 2446
            .|:.:|:.                        .:..|.:.|..    ||:.|  :|         
  Fly  1162 FALVNRSR------------------------AISVEFLRPGN----GEYSF--NW--------- 1187

Human  2447 KHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL 2511
                  |:|:       |...:::|.|               ||                     
  Fly  1188 ------MELI-------PRPTLSMAED---------------CQ--------------------- 1203

Human  2512 QDDLTCRAVNSSCRAQDEFECAN-GECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS 2574
                              |:||. |.|:|.|:.||||.||....||            ||.|||
  Fly  1204 ------------------FKCAELGACVNASVWCDGVVHCPSGDDE------------TFLQCS 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_002323.2 LDLa 26..59 CDD:197566
Ldl_recept_a 71..104 CDD:395011
FXa_inhibition 119..148 CDD:464251
FXa_inhibition 158..188 CDD:464251
LY 275..314 CDD:214531
LDL-receptor class B 1 292..334
LY 316..358 CDD:214531
LDL-receptor class B 2 335..378
LY 361..401 CDD:214531
LDL-receptor class B 3 379..422
FXa_inhibition 486..519 CDD:464251
LY 551..593 CDD:214531
LDL-receptor class B 4 571..613
LY 594..633 CDD:214531
LDL-receptor class B 5 614..659
LY 640..689 CDD:214531
LDL-receptor class B 6 660..710
LY <700..733 CDD:214531
LDL-receptor class B 7 711..754
FXa_inhibition 807..842 CDD:464251
LDLa 853..885 CDD:197566
LDLa 895..928 CDD:238060
LDLa 935..967 CDD:197566
LDLa 978..1011 CDD:238060
LDLa 1015..1048 CDD:238060
LDLa 1062..1097 CDD:238060
LDLa 1104..1140 CDD:238060
LDLa 1145..1178 CDD:238060 13/32 (41%)
FXa_inhibition 1185..1221 CDD:464251 3/35 (9%)
LDL-receptor class B 8 1309..1355 9/45 (20%)
Vgb 1310..>1503 CDD:443399 35/193 (18%)
LY 1336..1376 CDD:214531 4/39 (10%)
LDL-receptor class B 9 1356..1398 4/41 (10%)
LY 1380..1423 CDD:214531 3/42 (7%)
LDL-receptor class B 10 1399..1445 4/45 (9%)
LDL-receptor class B 11 1446..1490 15/44 (34%)
LDL-receptor class B 12 1491..1531 7/39 (18%)
LY 1613..1649 CDD:214531 9/35 (26%)
LDL-receptor class B 13 1627..1669 9/49 (18%)
LY 1650..1693 CDD:214531 9/50 (18%)
LDL-receptor class B 14 1670..1713 12/47 (26%)
LY 1697..1734 CDD:214531 13/46 (28%)
LDL-receptor class B 15 1714..1753 7/43 (16%)
LY 1734..1775 CDD:214531 6/40 (15%)
LDL-receptor class B 16 1754..1798 7/43 (16%)
FXa_inhibition 1850..1886 CDD:464251 7/49 (14%)
YncE 1872..2084 CDD:442618 41/238 (17%)
LDL-receptor class B 17 1934..1976 7/50 (14%)
LY 1959..1999 CDD:214531 8/43 (19%)
LDL-receptor class B 18 1977..2019 6/42 (14%)
LDL-receptor class B 19 2020..2063 9/42 (21%)
Ldl_recept_b 2020..2061 CDD:459654 8/40 (20%)
LY 2045..2087 CDD:214531 8/41 (20%)
LDL-receptor class B 20 2064..2107 6/45 (13%)
FXa_inhibition 2159..2194 CDD:464251 8/37 (22%)
LDL-receptor class B 21 2253..2294 14/90 (16%)
LDL-receptor class B 22 2295..2343 12/49 (24%)
LDL-receptor class B 23 2344..2388 7/43 (16%)
Ldl_recept_b 2344..2386 CDD:459654 7/41 (17%)
LY 2370..2411 CDD:214531 4/40 (10%)
LDL-receptor class B 24 2389..2431 3/41 (7%)
LDL-receptor class B 25 2432..2473 6/40 (15%)
FXa_inhibition 2482..2517 CDD:464251 2/34 (6%)
LDLa 2527..2557 CDD:238060 14/30 (47%)
LDLa 2566..2600 CDD:238060 5/9 (56%)
LDLa 2605..2639 CDD:238060
LDLa <2666..2688 CDD:238060
LDLa 2696..2730 CDD:238060
LDLa 2734..2765 CDD:197566
LDLa 2773..2806 CDD:197566
LDLa 2817..2849 CDD:197566
LDLa 2857..2890 CDD:197566
LDLa 2907..2939 CDD:238060
cEGF 2964..2985 CDD:463661
EGF_CA 2982..>3011 CDD:214542
LY 3049..3093 CDD:214531
LDL-receptor class B 26 3069..3113
LY 3094..3136 CDD:214531
LDL-receptor class B 27 3114..3156
LY 3138..3180 CDD:214531
LDL-receptor class B 28 3157..3200
LY 3182..3223 CDD:214531
LDL-receptor class B 29 3201..3243
LY 3224..3264 CDD:214531
LDL-receptor class B 30 3244..3284
FXa_inhibition 3294..3330 CDD:464251
LDLa 3334..3365 CDD:238060
LDLa 3374..3408 CDD:238060
LDLa 3413..3448 CDD:238060
LDLa 3452..3485 CDD:197566
LDLa 3493..3526 CDD:197566
LDLa 3536..3570 CDD:238060
LDLa 3575..3609 CDD:238060
LDLa 3613..3647 CDD:238060
LDLa 3653..3685 CDD:197566
LDLa 3695..3731 CDD:238060
LDLa 3746..3776 CDD:238060
YncE 3862..4064 CDD:442618
LDL-receptor class B 31 3912..3954
Recognition site for proteolytical processing. /evidence=ECO:0000255 3940..3943
LY 3955..3992 CDD:214531
LDL-receptor class B 32 3970..4012
LDL-receptor class B 33 4013..4056
Ldl_recept_b 4013..4054 CDD:459654
LY 4037..4078 CDD:214531
LDL-receptor class B 34 4057..4101
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7 4445..4544
NPXY motif 4502..4507
CG32432NP_649266.1 LDLa 214..245 CDD:197566 13/32 (41%)
CUB 503..646 CDD:238001 40/213 (19%)
LDLa 1203..1231 CDD:197566 14/66 (21%)
Blue background indicates that the domain is not in the aligned region.

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