DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and LRP1

DIOPT Version :10

Sequence 1:NP_002323.2 Gene:LRP1 / 4035 HGNCID:6692 Length:4544 Species:Homo sapiens
Sequence 2:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster


Alignment Length:4909 Identity:1760/4909 - (35%)
Similarity:2512/4909 - (51%) Gaps:660/4909 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRL 91
            |....|.|.|.. ||...|:||.:.||||.|||..|..|     :|...:..|..:..|:|.:.|
  Fly    87 CPASYFTCNDGF-CIPMRWKCDSKADCPDMSDEGSECAP-----KCNEGQFRCGVSRHCIPNNWL 145

Human    92 CNGVQDCMDG--SDE-------GPHCRELQGN--------------------------------C 115
            |:|..||..|  |||       .|.||..:|.                                |
  Fly   146 CDGEFDCGKGDISDELNCPNGDTPKCRAFEGQCRNGDCLELSRFCDGRWDCDNDELQCDKQNAAC 210

Human   116 SRLGCQHHCVPTLDGPTCYCNSSFQLQADGKT-CKDFDECSVYGTCSQLCTNTDGSFICGCVEGY 179
            :.|.|..:|..|..|..|||......::...| |.|:||||..|||.|:|.||.||:.|.||.||
  Fly   211 AALNCSFNCKLTPQGARCYCPKDQVPESSNSTRCVDYDECSEPGTCDQVCRNTPGSYECSCVSGY 275

Human   180 LLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTT------------- 231
            .....|| |:|.|.|...|..|:..:...:.:...:|.:|  |.|...:...             
  Fly   276 AKTKGNR-CRAINVPPTEPTTLIFLSRDGVQSVGTNGTEV--IGPPGAKDNDKVTDKDGVGSEEE 337

Human   232 -----------AMDFSYANETVC-----WVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSL- 279
                       |.:..:.|.|:|     |       .:.|::|.|       ||:..:|.:|.. 
  Fly   338 LLLSQPLRFVHAFEVWHRNRTLCSLLFSW-------PELQMRCQR-------VDDARVNWTLPFS 388

Human   280 ------HHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNP-KGIALDPAMGKV 337
                  ....::.:|||:||:|.|.:.|..:::|......|..:  |:..:| ..:.|||..|.:
  Fly   389 SFVSPQQFFTELRLDWLSGNWYLVSEDDGLVYLCTNAMTYCRVI--LQQVDPLSSLDLDPTKGFM 451

Human   338 FFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQ 402
            |:||:  .|.:.|..:||.|||.||..::..|..:||||.:.||||.|.|.|.:..|||||:.|.
  Fly   452 FYTDW--TPSLSRSLLDGSNRTVLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNRW 514

Human   403 TIIQ----GILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALH 463
            |:.:    .:.::.::.:.||||.:|..      |...|:::.:::|:...:.:.:.|.:|..|.
  Fly   515 TLKRPLDSPVPLKTIHAVEVFENSIYLA------AWMDTAIVALDKFSLKTHILQSNVSRGANLR 573

Human   464 IYHQRRQPRVRSHACENDQYGKPGGCSDICL--LANSHKARTCRCRSGFSLGSDGKSCKKPEHEL 526
            |:|:::||.| :|.|.::.    .||:.||:  ......:..|.|.:|:.|.:. .:|.....:.
  Fly   574 IFHRQKQPEV-AHPCRDNN----AGCNQICVPQWTKGFASAKCMCTAGYKLHNQ-TTCLLSALDK 632

Human   527 FLVYGKGRPGIIRGMDMG----------AKVPDEHMIPIENLMNPRALDFHAETGFIYF--ADT- 578
            ||||.......|.|:.:.          .:.||. |:|:.|:....|:|.:.....:::  ||: 
  Fly   633 FLVYSDKHLARISGIPLDTEQVQQLEQIGEQPDV-MVPVYNVSKTLAIDVNVRGKAVFYVVADSG 696

Human   579 --------TSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKA 635
                    .|..|..|.::|:. ..:|..|:..|..||.||:.|:||||.   .|.:.||.|...
  Fly   697 ASPFGNGEPSCSIRSQSLNGSV-SRLLAQGLKRVHAVAFDWINDHLYWTS---HKKMQVAPLRNL 757

Human   636 AQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIF---VTSKT 697
            :   |.|.........::.:||..|.:||:.||   ..|....:..:||||:|:::.   .:|..
  Fly   758 S---KVLTFNTDCDAMSLELDPTTGLLYWSQWE---SQSCEAGIYSSWMDGTHKELLAKGTSSMP 816

Human   698 VLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRS 762
            :.||..|.:|.....|||.|.....||.:.|:||.|:::::..:. |.:.:..:...::|.:.::
  Fly   817 MQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGREVLFKSDQF-HPYSIVQNNGLIYWADNKN 880

Human   763 GSVYRLERGVGGA----PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPG 823
            .::.|........    ..||.|.|:.|..  ::|::|...|.:...........|..:||.||.
  Fly   881 STILRFHAHQANLSSTFSSTVHLQRTGRAA--DLRIFDIASQPLPQTPSACAQSKCPGMCLNTPK 943

Human   824 SRQCACAEDQVLDADGVTCLANPSYVPP---PQCQPGEFACANSR-CIQERWKCDGDNDC---LD 881
            ...|.|.:...|:..|..|:  |...|.   |.|..| :.|.::| |:..:..|||..||   :|
  Fly   944 GAICRCPDGFTLNGTGSHCI--PQLAPSPIRPNCTSG-YMCRSTRQCLDTKDMCDGFEDCEDGID 1005

Human   882 NSDEAPALCHQHTC-PSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC-A 944
            .|.:....|:.:|| .:..|.| |.||.....||.....|.:..|::|  |...||..|:|:| .
  Fly  1006 ESSDPKGPCNVNTCDKTHNFVC-NGRCYQRSLLCSTIPYCSDGTDQAN--CHQNTCNSNEFTCHK 1067

Human   945 SGRCIPISWTCDLDDDCG--DRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSD 1007
            |||||.::|..|...|||  |.|||::...:.:..|  :|.||||||......||..::||:|:|
  Fly  1068 SGRCIQLTWVNDGVVDCGPDDDSDETSETIFASKCP--EFDCNNGRCRQFADVCDGIDNCGNNAD 1130

Human  1008 EAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP------GGCHTDE 1066
            |..|...|...:..|....|..|...|||.:||.|:|||.:.|.|.....|.      |.|...|
  Fly  1131 EMECEQECEHGEKYCRPIGCYGEMHMCDGIHDCLDFSDEANCNQTKSDNHPVTEWKELGECAPLE 1195

Human  1067 FQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDC 1131
            |.|.....|||...||||.:.|.|.:||.:|   ||:  .:.:|...                  
  Fly  1196 FACMFPFECIPDFLRCDGISHCFDKTDEFNC---THI--NTTRFDMN------------------ 1237

Human  1132 EDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELC-DQCSLNNGGCSHN 1195
                     |::.|..|...|..:.. |:..|:||||.:||.|.:|||.|| |:.......|||.
  Fly  1238 ---------ETVICEHPDRLCGFSKQ-CVTVDQLCDGKNDCEDTTDEGFLCADKLCDRGHECSHR 1292

Human  1196 CSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES 1260
            |...| ||.:||||..:.|.|:...|.:|..|.....|||.|:.:.....|.|.:|:.|..|..:
  Fly  1293 CHNTP-EGYICSCPDHLYLQPNGKRCSMQHACDHWDTCSQVCESSGKGYDCRCLDGFDLGFDRFT 1356

Human  1261 CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDF---HLSQSALYWTDVVEDKIY 1322
            |:|..|.:|::||:||.:|:.|:|...:.......|||.|||||   :.|...:|||||::||||
  Fly  1357 CKSTAPDEPYVIFTNRQDIKGINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIY 1421

Human  1323 RGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIE 1387
            ||.|:.. :|.:.|.||..||:|.|||||||:..|:||::|||||||||||:|:.|.||:||::|
  Fly  1422 RGHLVGE-SLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNME 1485

Human  1388 HPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETG-SGGWPNGLTVDYLEKRILWI 1451
            .|||||||||:|:|||||||.:.||||.|||||.|||.:..... |.|||||||:||.:||:.|:
  Fly  1486 SPRAIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWV 1550

Human  1452 DARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQ 1516
            ||:||:|.|..||||.|..|||..|.||||||::::...||||||||.::.:||||.|.:|.|:|
  Fly  1551 DAKSDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQ 1615

Human  1517 RTNTQPFDLQVYHPSRQPMAPNPC-EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDN-TTCY 1579
            ||.:|||.:||.|.||||...||| |.|||   ||||||::...|..|.|||:|:|...| ..|.
  Fly  1616 RTQSQPFGIQVLHSSRQPWDRNPCGENNGG---CSHLCLLSGRGTFKCECPHVMRLDPANERNCV 1677

Human  1580 EFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL------DYDAREQRVYWSDVRTQA 1638
            ..::.||:....||||:||..|.::     |:|.|.....|      |:...|.|::|||::...
  Fly  1678 PNEQVLLFVMVDEIRGIDLHQPNHH-----TIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNE 1737

Human  1639 IKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQ 1703
            |..|.|:...:|.:::.::...:|.||||::||::::|... |..|..:.|.|.|.:.:.:.|..
  Fly  1738 ISSAGISNGLIEPIINTNIEKPYGFAVDWIARNMYFSSGQI-KCNILASNLKGEFASIIHEDLNM 1801

Human  1704 PHGLVVHPLRGKLYW----TDG--DNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSG 1762
            ...:|:.|..||:||    :||  ..:..:|:|||:|:|::..:.....|.:||...:||:.   
  Fly  1802 VDSIVLDPANGKMYWIHSASDGSMSQLEQSNLDGSSRSLIYQHENNLQSLTMDFDSQRLYYA--- 1863

Human  1763 NHTINRCNLDGSGLEVIDAMRSQLGKA---------TALAIMGDKLWWADQVSEKMGTCSKADGS 1818
                    .|.||:...|..|::..|.         ::|.:....|::.:.:...:..|.|...|
  Fly  1864 --------YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACS 1920

Human  1819 GSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCS--VNNGDCSQLCLPTSETTRSCMCTAGYSLR- 1880
            ....||.:|..:..||::....|   .|:|.|:  ...|.|.||||.||.....|.|..||.:. 
  Fly  1921 NMSYLRVNTKSIQSMKMFYADAQ---TGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEP 1982

Human  1881 SGQQACEGVGSFLLYSVHEGIRGIP-LDPNDKSD----ALVPVSGTSLAVGIDFHAENDTIYWVD 1940
            :....|.....|:.||: :.::|:. :||:::.|    ||||:|..|.|..||:.|..||:||.|
  Fly  1983 NNPTGCVPRAEFIFYSI-DVLQGVEMIDPSEQFDTPSPALVPISRVSSASFIDYLANTDTLYWGD 2046

Human  1941 MGLSTISRAKRDQTWREDVV--TNGIGRVE-----GIAVDWIAGNIYWTDQGFDVIEVARLNGSF 1998
            ..|.:|||.|||.|.||.::  .|.:|..:     |||:||:||||||:|...::||||||:||.
  Fly  2047 NELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSH 2111

Human  1999 RYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVN-VSISWPNG-ISVDY 2061
            ||||:| .|:||.|:.|.|.:|.||:.   ....|.|..|||::..|||| ...:|..| :.:|.
  Fly  2112 RYVVVS-NLEKPTALAVDPLQGLLFYV---TQQHIGRVGLDGSQPFVLVNQTRANWAVGSLVLDI 2172

Human  2062 QDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKD 2126
            :..|:|||:...|.:.::|.: |..||.:|:.:..:..:::...|::||::..:..|.|:.....
  Fly  2173 EATKVYWCERYPDALMKVDYD-GNLREQLLNESLNNPVALAKMGDYLYWAENKYNEGIIRVAPLA 2236

Human  2127 NATDS-VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAED 2190
            |.:.| |.|:|.... ::|:|::::..|:|:|.||.:||.|:||||:.|. ...|||||..||.|
  Fly  2237 NLSQSKVVLQTEQDA-IRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGT-SAVCACAHSRLASD 2299

Human  2191 GASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRI 2255
            |.||..|..:||:|.|:.::|||::|..:.|.|||...:...|:||||:.::|.       ...:
  Fly  2300 GYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYE-------EQLV 2357

Human  2256 FFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTI----TRHTVDQTR 2316
            ::||:....|.|::.:|:....::|....||||||....:.|:|||...:||    .||..:...
  Fly  2358 YYSDVQLSTINQVHFNGTGHRVLLEQQQRVEGLAYDIVNEQLFWTSNNNATIRSVELRHLSEHAD 2422

Human  2317 PGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNG 2381
            ......:.|:::..||.||...::.|..:::||||||..|.|.|:.|:|.....:|:.||:.||.
  Fly  2423 QNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVIIKTDIKMPNA 2487

Human  2382 LAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRAN 2446
            |.:|...:|||::||.||||||..||||:|.|:..|.|.|.|.:||||:.:||||||..||.|||
  Fly  2488 LTLDLEQQKLYWADARLDKIERTNYDGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRAN 2552

Human  2447 KHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL 2511
            |:.|:::..||..: .:||||:||.|.:.:|:.:.|:|.||.|:|:|:|...|...|.|..|.:.
  Fly  2553 KYTGTDVLFLREHV-TRPMGIVAVQNTSINCDANQCKILNGQCEDVCILNKSGQATCHCTQGVLA 2616

Human  2512 QDDLTCRA-VNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSN 2575
            .|...|.| ||:|| ...::.|.:||||...||||.|.||.|.|||..|||..|:|.:|...|.|
  Fly  2617 PDGRRCIAPVNTSC-GLSQYNCHSGECIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQN 2680

Human  2576 GRCVSNMLWCNGADDCGDGSDEIP----C-----------NKTACGVGEFRCRDGTCIGNSSRCN 2625
            .||:.....|:|...|||||||.|    |           |.|......|||..|.||.....|:
  Fly  2681 HRCIPKEHKCDGEQQCGDGSDETPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCD 2745

Human  2626 QFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPG 2690
            ...||.|.|||..|:...|..      ..:.|..|..:::|..|.|.|||..||.|.:||.||..
  Fly  2746 SLKDCRDFSDEKMCAPIPCEK------NDMTFVHCGNSTICIMPRWRCDGDPDCPDGTDELDCAN 2804

Human  2691 VKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDG 2755
            .....|....|.|.||.||..||.||.|.||..|.||.:|...|...||.| :..||...|.|||
  Fly  2805 HTSLSCDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFAC-DKTCIPASWQCDG 2868

Human  2756 SDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADG-ADESI------AAGCL 2813
            ..||.|||||...|..:.|.|..|.|..:..|:|::|:|||:|||..| .||..      ..|..
  Fly  2869 KSDCEDGSDEGPQCPNRPCRPHLFQCKSSGRCIPQKWVCDGEKDCPSGLGDEGSEDEGPQCGGVA 2933

Human  2814 YNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPEC----EYPTC--GPSEFRCANGRCLS 2872
            :...|.....:|.:..||..|:|||.|.||..|.||...|    :..:|  |....:|.:|.|:.
  Fly  2934 HIPDCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEYEGCVPAFQPHSCPGGSLMHQCQDGLCIF 2998

Human  2873 SRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDER 2937
            ..| .|||:.||.|.|||...   ..:....||.:..|.|.:|.|:...|||:.::||.|.|||.
  Fly  2999 KNQ-TCDGKPDCGDGSDETSS---LCAHTRGCNGTDDFRCKNGACIHADLLCDRRNDCADFSDEE 3059

Human  2938 GCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFR-LKDDGRTCADVDECSTTFPCSQRCINTHG 3001
            .|::||||...:  |..:|||..:|::|.||||:: |......|.|:|||....||||.||||:|
  Fly  3060 LCNVNECLIPDI--CEHECEDKVVGYQCHCRPGYKVLPKSPHLCTDIDECDEQQPCSQTCINTYG 3122

Human  3002 SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDY 3066
            ||||||.:|||.  .|.|:|||.::....|||:||||:|::::.|:...|:.: |:||||||:|:
  Fly  3123 SYKCLCAKGYAL--VDHHTCKATSNVSMELIFSNRYYIRQVDMTGNGSILINE-LSNAVALDYDW 3184

Human  3067 REQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKL 3131
            ..|.:||:|||:....|:|.....:..|.||:..|.||||||||||..||||||||.||||||:|
  Fly  3185 DSQCLYWSDVTSTVGTIKRYCPKENKTQTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQL 3249

Human  3132 NGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTL 3196
            :|.||.||::..|||||.:.:.....:::|:||||...||:.|||||:..:|:...:.|||.||:
  Fly  3250 DGKYRKVLINEYLREPRGIALHPYQQHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTI 3314

Human  3197 DYVTERIYWADAREDYIEFASLDGSNRHVVLSQDI------PHIFALTLFEDYVYWTDWETKSIN 3255
            .:.|::::|.|||||.|..:.|||::..::|::.|      .||||:.::|.::||:|||||||.
  Fly  3315 SFETQQLFWGDAREDTISVSDLDGNHTRLLLARSINPLLNLHHIFAIAVWEGHIYWSDWETKSIE 3379

Human  3256 RAHKTTGTNKTLLISTLHRPMDLHVFHALRQPD-VPNHPCKVNNGGCSNLCLLSPGGG-HKCACP 3318
            ......|.|.|.||:|:||||||.|||..||.. :..:||...|  ||.||:|||... :||.||
  Fly  3380 YCSIFNGQNCTTLITTIHRPMDLRVFHPYRQQQPMSGNPCLAAN--CSTLCVLSPEEPYYKCMCP 3442

Human  3319 TNFYLGSDGRTCVSNCTASQFVCKND-KCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCS 3382
            |||.|..|||||.:||||:.|.|.|. |||||:|:|||:|||||.||||..||.|.|.|||:||:
  Fly  3443 TNFILADDGRTCRANCTAAHFECVNTYKCIPFYWRCDTQDDCGDGSDEPETCPPFHCEPGQYQCA 3507

Human  3383 TGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNR----CIPGIFRCNGQDNCGDGE 3443
            ...||:|:.:|||.|.|.|.|||.|||...|..:..||..|..    |:..:.||:|..:|..||
  Fly  3508 NKKCTHPSNLCDGINQCGDGSDELNCDKFTCFDNHMKCGATANSSAFCVDNVKRCDGVKDCPGGE 3572

Human  3444 DERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCI 3508
            ||..|..:.|..:||||. ..||:|.|||||.|.||.|.||| |||..::||.::|:| ||||||
  Fly  3573 DESACTPLVCKKDQFQCG-NNRCMPFVWVCDGDIDCPDKSDE-ANCDNVSCGPNDFQC-DSGRCI 3634

Human  3509 PARWKCDGEDDCGDGSDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCT 3571
            |..|:||.:.||.:|.||| ..|  .:.||:|..|:|.|::|:||||:|||:|||||.|||.:|.
  Fly  3635 PLAWRCDDDHDCPNGEDEP-ASCFSSKATCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNCQ 3698

Human  3572 PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS-GHCIPLRWRCDAD 3635
            .|.||||||.|..|:||...::|||:..|.|.|||.:|...|..:||:|.: ..||..:::||.|
  Fly  3699 MRNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINCNITCKENQFKCAAFNTCINKQYKCDGD 3763

Human  3636 ADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRP 3700
            .||.|||||..|     ||..|.|.|.|..|....|||||.|||.|.|||:.|.||:..|..| .
  Fly  3764 DDCPDGSDEVNC-----TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDESLETCAKTHCHAN-A 3822

Human  3701 FRCKNDRVCLWIGRQCDGTDNCGDGTDEED--CEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNM 3763
            |:|:| ::|:.....|||.::||:..||.|  |    |....|: ..:|.|.|..|:|.:.||:.
  Fly  3823 FKCRN-QLCVRNSALCDGINDCGENEDESDAVC----AALPKCR-HDQFQCENDDCISKAFRCDG 3881

Human  3764 FDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINEC 3828
            ..:|.|||||.:|           ...:||                                   
  Fly  3882 QYNCVDGSDEMNC-----------QPPVCG----------------------------------- 3900

Human  3829 LRFGTCSQLCNNTKGGHL-CSCARNFMK---THNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSA 3889
              ||:|||:|...|.||. |.||..:.|   .:.||.|.|.: |:|.:|.:.|.|.:.|......
  Fly  3901 --FGSCSQICIEKKAGHYNCKCADGYHKGPEKNATCLASGPD-QILLLASEQEFRFILPAKQEGT 3962

Human  3890 YEQAFQGDESVRIDAMDVHV--KAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHL 3952
            ....|...:|::||..|:.:  |...::|.:.|.|.:....:.......|..|.||.: :.:|..
  Fly  3963 TVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTGVRVRRDL-KELTAF 4026

Human  3953 NISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLIS-GMIDEPHAIVVDPLRGTMY 4016
            ||..|..|:.:|:||::..||..||..:.|....::|:...:|:| ||  .|..||::|....|.
  Fly  4027 NIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGM--NPTDIVLEPESRIMI 4089

Human  4017 WSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTD-PI 4080
            ||...|  .|..|::||:.:::||:.::.||..|::||...||||||.:...|.:.||||.| .:
  Fly  4090 WSTLEN--GILVASLDGSNKKSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDRNV 4152

Human  4081 VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQ- 4144
            |.....|  ..|..|||||||:| :...:..:.|::|||:.....|..|. .:||:.:.|..|| 
  Fly  4153 VRRFGNR--EKPQKIDVFEDYLY-IKLYDQSIIKMNKFGNDNGTYLLKGY-RSSDIGILHPMKQN 4213

Human  4145 PEVTNPCDRKKCE---WLCLLSPSGPV---CTCPNGKRL-DNGTC-----VP------------- 4184
            ..::|||.:..|:   .||:||....|   |.|..|..: |:|.|     :|             
  Fly  4214 RNISNPCAKDPCKSSRALCILSSESSVGYSCKCAEGYVMTDDGVCKAHADIPDYCPLQCNLGTCK 4278

Human  4185 ----VP------------------------------------SPTPPP--------------DAP 4195
                ||                                    |..|||              :..
  Fly  4279 IVDHVPKCICQPQFEGELCEHYRCSGYCQNYGVCSVAPALPGSQEPPPLKCTCTAGWSGARCETS 4343

Human  4196 RPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCR-----NGGTCAASPSGMPT 4255
            .| .|..:|.|||||.::.....||.|...:||::|      ||||     |||.|..:.:|.|.
  Fly  4344 MP-ACQSRCHNGGSCLISETEGMKCSCPKMFTGEQC------EHCRNLTCENGGICRETLTGTPQ 4401

Human  4256 CRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM 4320
            |.||.||||.:|....||.:|.|..:|.::...|.||:|..|:.|:.|:...|..:|.|.|||. 
  Fly  4402 CECPDGFTGKRCEIDECADFCKNGGSCVISTKGQRQCKCPSGYFGEHCESNSCRDFCRNGGTCS- 4465

Human  4321 AADGSRQCRCTAYFEGSRCEVNKCSR-----------------CL------EGACVVNKQSGDVT 4362
            ...|...|.|...:.|..||.:.|..                 |.      .|.|.:.|  |...
  Fly  4466 ERGGRLSCTCPPRYIGESCESDLCKTSSPPHFCDNTKVPTRDPCTLMICQNAGTCHIIK--GVAL 4528

Human  4363 CNCTDGRVAPSCL-------TCVGHCSNGGSCTMNSKMMPECQC-----------PPHMTGPRCE 4409
            |||||......|.       .|..:|:|||.|.::...:|.|.|           |||..|..|.
  Fly  4529 CNCTDQWNGDLCTLPVTDDNPCARYCANGGVCHLDEYRLPHCSCIGEWQGNACEMPPHCVGGECN 4593

Human  4410 --------------------------EHVFSQQQP---GHIASILIPLLLLLLLV--LVAGVVFW 4443
                                      :.:..:|:|   |.:.|:::.:|.::|||  |.||.|::
  Fly  4594 VCRPGSSINECLCENNRVVPCLSDSADALKEEQEPTESGGVFSVVVLVLAVILLVFALFAGAVYF 4658

Human  4444 YKR-RVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDAD----FALDPDKPTNFT 4503
            .|: |:  |:.|.|.|:|:   |||| ..|..||.|          |||    ||.:.|| .||.
  Fly  4659 LKKHRI--AQPFSHARLTD---NVEI-MLTNAMYRG----------DADEAPTFASEDDK-GNFA 4706

Human  4504 NPVYATLYMGGHGS------RHSLASTDEKRELL 4531
            ||||.::|......      .||.| .||::.||
  Fly  4707 NPVYESMYADAIPEPVSTEITHSTA-PDERKGLL 4739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_002323.2 LDLa 26..59 CDD:197566 14/31 (45%)
Ldl_recept_a 71..104 CDD:395011 11/34 (32%)
FXa_inhibition 119..148 CDD:464251 8/29 (28%)
FXa_inhibition 158..188 CDD:464251 16/29 (55%)
LY 275..314 CDD:214531 10/45 (22%)
LDL-receptor class B 1 292..334 12/42 (29%)
LY 316..358 CDD:214531 13/42 (31%)
LDL-receptor class B 2 335..378 18/42 (43%)
LY 361..401 CDD:214531 19/39 (49%)
LDL-receptor class B 3 379..422 17/46 (37%)
FXa_inhibition 486..519 CDD:464251 8/34 (24%)
LY 551..593 CDD:214531 11/52 (21%)
LDL-receptor class B 4 571..613 13/52 (25%)
LY 594..633 CDD:214531 15/38 (39%)
LDL-receptor class B 5 614..659 13/44 (30%)
LY 640..689 CDD:214531 14/48 (29%)
LDL-receptor class B 6 660..710 16/52 (31%)
LY <700..733 CDD:214531 13/32 (41%)
LDL-receptor class B 7 711..754 11/42 (26%)
FXa_inhibition 807..842 CDD:464251 9/34 (26%)
LDLa 853..885 CDD:197566 12/35 (34%)
LDLa 895..928 CDD:238060 10/33 (30%)
LDLa 935..967 CDD:197566 17/34 (50%)
LDLa 978..1011 CDD:238060 15/32 (47%)
LDLa 1015..1048 CDD:238060 13/32 (41%)
LDLa 1062..1097 CDD:238060 15/34 (44%)
LDLa 1104..1140 CDD:238060 1/35 (3%)
LDLa 1145..1178 CDD:238060 12/32 (38%)
FXa_inhibition 1185..1221 CDD:464251 13/35 (37%)
LDL-receptor class B 8 1309..1355 26/45 (58%)
Vgb 1310..>1503 CDD:443399 118/193 (61%)
LY 1336..1376 CDD:214531 27/39 (69%)
LDL-receptor class B 9 1356..1398 29/41 (71%)
LY 1380..1423 CDD:214531 31/42 (74%)
LDL-receptor class B 10 1399..1445 30/46 (65%)
LDL-receptor class B 11 1446..1490 24/43 (56%)
LDL-receptor class B 12 1491..1531 24/39 (62%)
LY 1613..1649 CDD:214531 11/41 (27%)
LDL-receptor class B 13 1627..1669 13/41 (32%)
LY 1650..1693 CDD:214531 13/42 (31%)
LDL-receptor class B 14 1670..1713 11/42 (26%)
LY 1697..1734 CDD:214531 13/42 (31%)
LDL-receptor class B 15 1714..1753 15/44 (34%)
LY 1734..1775 CDD:214531 8/40 (20%)
LDL-receptor class B 16 1754..1798 9/52 (17%)
FXa_inhibition 1850..1886 CDD:464251 13/38 (34%)
YncE 1872..2084 CDD:442618 90/226 (40%)
LDL-receptor class B 17 1934..1976 22/48 (46%)
LY 1959..1999 CDD:214531 22/46 (48%)
LDL-receptor class B 18 1977..2019 25/41 (61%)
LDL-receptor class B 19 2020..2063 15/44 (34%)
Ldl_recept_b 2020..2061 CDD:459654 14/42 (33%)
LY 2045..2087 CDD:214531 14/43 (33%)
LDL-receptor class B 20 2064..2107 10/42 (24%)
FXa_inhibition 2159..2194 CDD:464251 19/34 (56%)
LDL-receptor class B 21 2253..2294 12/40 (30%)
LDL-receptor class B 22 2295..2343 13/51 (25%)
LDL-receptor class B 23 2344..2388 18/43 (42%)
Ldl_recept_b 2344..2386 CDD:459654 17/41 (41%)
LY 2370..2411 CDD:214531 22/40 (55%)
LDL-receptor class B 24 2389..2431 25/41 (61%)
LDL-receptor class B 25 2432..2473 21/40 (53%)
FXa_inhibition 2482..2517 CDD:464251 13/34 (38%)
LDLa 2527..2557 CDD:238060 15/29 (52%)
LDLa 2566..2600 CDD:238060 16/37 (43%)
LDLa 2605..2639 CDD:238060 13/33 (39%)
LDLa <2666..2688 CDD:238060 11/21 (52%)
LDLa 2696..2730 CDD:238060 17/33 (52%)
LDLa 2734..2765 CDD:197566 15/30 (50%)
LDLa 2773..2806 CDD:197566 14/33 (42%)
LDLa 2817..2849 CDD:197566 12/31 (39%)
LDLa 2857..2890 CDD:197566 13/34 (38%)
LDLa 2907..2939 CDD:238060 13/31 (42%)
cEGF 2964..2985 CDD:463661 8/21 (38%)
EGF_CA 2982..>3011 CDD:214542 19/28 (68%)
LY 3049..3093 CDD:214531 17/43 (40%)
LDL-receptor class B 26 3069..3113 21/43 (49%)
LY 3094..3136 CDD:214531 30/41 (73%)
LDL-receptor class B 27 3114..3156 25/41 (61%)
LY 3138..3180 CDD:214531 19/41 (46%)
LDL-receptor class B 28 3157..3200 18/42 (43%)
LY 3182..3223 CDD:214531 17/40 (43%)
LDL-receptor class B 29 3201..3243 17/47 (36%)
LY 3224..3264 CDD:214531 17/45 (38%)
LDL-receptor class B 30 3244..3284 24/39 (62%)
FXa_inhibition 3294..3330 CDD:464251 20/36 (56%)
LDLa 3334..3365 CDD:238060 21/31 (68%)
LDLa 3374..3408 CDD:238060 18/33 (55%)
LDLa 3413..3448 CDD:238060 13/38 (34%)
LDLa 3452..3485 CDD:197566 18/32 (56%)
LDLa 3493..3526 CDD:197566 17/32 (53%)
LDLa 3536..3570 CDD:238060 21/33 (64%)
LDLa 3575..3609 CDD:238060 18/33 (55%)
LDLa 3613..3647 CDD:238060 16/34 (47%)
LDLa 3653..3685 CDD:197566 17/31 (55%)
LDLa 3695..3731 CDD:238060 14/37 (38%)
LDLa 3746..3776 CDD:238060 13/29 (45%)
YncE 3862..4064 CDD:442618 63/204 (31%)
LDL-receptor class B 31 3912..3954 8/41 (20%)
Recognition site for proteolytical processing. /evidence=ECO:0000255 3940..3943 1/2 (50%)
LY 3955..3992 CDD:214531 11/36 (31%)
LDL-receptor class B 32 3970..4012 14/42 (33%)
LDL-receptor class B 33 4013..4056 15/42 (36%)
Ldl_recept_b 4013..4054 CDD:459654 13/40 (33%)
LY 4037..4078 CDD:214531 18/40 (45%)
LDL-receptor class B 34 4057..4101 20/44 (45%)
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7 4445..4544 36/98 (37%)
NPXY motif 4502..4507 3/4 (75%)
LRP1NP_001260800.2 LDLa 87..118 CDD:197566 13/30 (43%)
LDLa 126..163 CDD:238060 10/38 (26%)
EGF_CA 246..283 CDD:214542 9/36 (25%)
Ldl_recept_b 449..487 CDD:459654 13/41 (32%)
LY 472..513 CDD:214531 8/40 (20%)
LY 817..852 CDD:214531 7/38 (18%)
LDLa 1057..1092 CDD:197566 11/34 (32%)
LDLa 1104..1134 CDD:238060 11/35 (31%)
LDLa 1191..1226 CDD:238060 6/34 (18%)
FXa_inhibition 1289..1317 CDD:464251 8/27 (30%)
LY 1434..1476 CDD:214531 28/41 (68%)
LY 1477..1521 CDD:214531 25/44 (57%)
LY 1533..1567 CDD:214531 18/33 (55%)
LY 1568..1611 CDD:214531 24/43 (56%)
FXa_inhibition 1639..1676 CDD:464251 12/36 (33%)
LY 1751..1789 CDD:214531 11/43 (26%)
LY 1794..1838 CDD:214531 10/43 (23%)
LY 2078..2112 CDD:214531 12/34 (35%)
NHL <2082..>2152 CDD:302697 23/71 (32%)
NHL repeat 2082..2120 CDD:271320 13/39 (33%)
FXa_inhibition 2269..2303 CDD:464251 13/33 (39%)
LY 2430..2471 CDD:214531 22/40 (55%)
LY 2475..2517 CDD:214531 21/41 (51%)
LDLa 2630..2661 CDD:238060 15/45 (33%)
LDLa 2671..2702 CDD:238060 13/30 (43%)
LDLa 2727..2759 CDD:238060 13/31 (42%)
LDLa 2773..2802 CDD:238060 13/28 (46%)
LDLa 2810..2844 CDD:238060 16/33 (48%)
LDLa 2848..2878 CDD:238060 12/36 (33%)
LDLa 2887..2916 CDD:197566 13/32 (41%)
LDLa 2938..2969 CDD:197566 11/30 (37%)
LDLa 2989..3015 CDD:197566 12/25 (48%)
LDLa 3030..3061 CDD:238060 15/31 (48%)
EGF_CA 3062..>3091 CDD:214542 14/28 (50%)
EGF_CA 3103..3141 CDD:214542 16/37 (43%)
LY 3212..3254 CDD:214531 16/41 (39%)
Ldl_recept_b 3275..3314 CDD:459654 17/44 (39%)
LY 3299..3340 CDD:214531 22/40 (55%)
LY 3354..3389 CDD:214531 19/35 (54%)
LDLa 3458..3490 CDD:238060 13/35 (37%)
LDLa 3499..3533 CDD:238060 16/33 (48%)
LDLa 3582..3616 CDD:238060 16/35 (46%)
LDLa 3621..3652 CDD:197566 18/30 (60%)
LDLa 3663..3697 CDD:238060 13/34 (38%)
LDLa 3702..3736 CDD:238060 15/33 (45%)
LDLa 3776..3808 CDD:197566 11/33 (33%)
LDLa 3818..3849 CDD:197566 9/30 (30%)
LDLa 3860..3894 CDD:238060 2/33 (6%)
YncE 3935..4148 CDD:442618 66/216 (31%)
LY 4108..4150 CDD:214531 17/42 (40%)
EGF_CA <4386..4414 CDD:238011 9/50 (18%)
EGF_CA 4415..4450 CDD:238011 14/41 (34%)

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