DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and CG6739

DIOPT Version :10

Sequence 1:NP_002323.2 Gene:LRP1 / 4035 HGNCID:6692 Length:4544 Species:Homo sapiens
Sequence 2:NP_609130.1 Gene:CG6739 / 34037 FlyBaseID:FBgn0031926 Length:787 Species:Drosophila melanogaster


Alignment Length:781 Identity:158/781 - (20%)
Similarity:229/781 - (29%) Gaps:272/781 - (34%)


- Green bases have known domain annotations that are detailed below.


Human  2288 LAYHRG---WDTLYWT-----------SYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFV 2338
            |.|.|.   |..|.|.           ...|..:..|.|...|....:|....|::........|
  Fly   112 LGYARSVCRWKYLRWPIIFVASVLLFFGLITYCLWLHDVSVARAKFLQRRYEATLTSTSSSSNEV 176

Human  2339 LDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIER 2403
            .||           |...|..|:......:..:.:.|..|        ...::.|.|....:...
  Fly   177 WDE-----------ETTSSTERSPQETTRLEDMDDSDEST--------ELPEIAFGDDGDPEAGG 222

Human  2404 CEYDGSHRYVILKSEPV-------HPFGLAVYGEHIFWTDWVRRAVQRANK--H------VGSNM 2453
            .:.||.:...:|.::.:       :.||:.:..:        :|.:|...:  |      .|:..
  Fly   223 EDGDGDYDDTLLPADSIRFTSGHQNSFGVPIEQD--------KRMLQLLKELLHKPQATPAGNEP 279

Human  2454 KLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC---RGGRILQDDL 2515
            .|.||. |..|..:.|....|.:..|:.....|.|||...|...||.::...   |.|...:|.:
  Fly   280 TLTRVS-PTLPPPLSASGRPTEAMALTTPSTTNSGCQSTMLPMCQGVLDYDLTFNREGAAPRDAV 343

Human  2516 TCRAVNSSCRAQ-----DEFECA--NGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC 2573
            :..|.:|..||.     .||.|.  ..||  ..|....:|.|:            |.||.....|
  Fly   344 SMAAYDSLIRANCSVRAAEFICGALEPEC--RPLHIGQLPPCR------------RICKAILEAC 394

Human  2574 SNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCE---DASD 2635
            |                       ||                  |.||....:..||.   ||.:
  Fly   395 S-----------------------IP------------------IYNSDVLGELFDCNLYPDAHE 418

Human  2636 EMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY 2700
            ...|.                 .|..|...||.                              |.
  Fly   419 SHKCE-----------------DPTRRRDYCYG------------------------------NE 436

Human  2701 FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSD 2764
            |.|..|.|||.:|.|||..||:.||||......|...:|.|: |.:|:.:::.||.:.||.||||
  Fly   437 FQCHDGSCIPQNWQCDKIKDCQGGEDEDEQCLVCEPDEFRCRSNEKCLVEKYRCDQNIDCMDGSD 501

Human  2765 EAAHCEGKTCGP------------------SSFSCPG-------THVCVPERWLCDGDKDCADGA 2804
            | ..|:....|.                  :||..|.       |::....      |:|.....
  Fly   502 E-QDCDEYGSGDLAPFDESELNAFPRVFTYASFLSPNETNDKVYTYITATT------DEDAGTET 559

Human  2805 DESI----AAGCLYNSTCDDREFMCQNRQCIPKHFVCDHD-RDCADGSDESPECEY--------- 2855
            ...|    |.....||:.::....       ||.||...| ::....||...:.:|         
  Fly   560 KFQIHQVAAPAPPVNSSAEEGAGG-------PKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSV 617

Human  2856 ------PTCG--------PSEFRCANGRCLSSRQWECDGENDCHDQSDEAPK------------- 2893
                  ||..        ||..........:|........:.........|.             
  Fly   618 KFSVSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPINAAT 682

Human  2894 ---NPH--------CTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSR 2947
               ||:        |..||.:        |.||:|:..:.||:.|.||.|::||..|...|..||
  Fly   683 SEPNPYEVVTSLGGCPPQELR--------CVSGKCITVSQLCDKQIDCPDAADELMCVYRERPSR 739

Human  2948 K 2948
            :
  Fly   740 R 740

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_002323.2 LDLa 26..59 CDD:197566
Ldl_recept_a 71..104 CDD:395011
FXa_inhibition 119..148 CDD:464251
FXa_inhibition 158..188 CDD:464251
LY 275..314 CDD:214531
LDL-receptor class B 1 292..334
LY 316..358 CDD:214531
LDL-receptor class B 2 335..378
LY 361..401 CDD:214531
LDL-receptor class B 3 379..422
FXa_inhibition 486..519 CDD:464251
LY 551..593 CDD:214531
LDL-receptor class B 4 571..613
LY 594..633 CDD:214531
LDL-receptor class B 5 614..659
LY 640..689 CDD:214531
LDL-receptor class B 6 660..710
LY <700..733 CDD:214531
LDL-receptor class B 7 711..754
FXa_inhibition 807..842 CDD:464251
LDLa 853..885 CDD:197566
LDLa 895..928 CDD:238060
LDLa 935..967 CDD:197566
LDLa 978..1011 CDD:238060
LDLa 1015..1048 CDD:238060
LDLa 1062..1097 CDD:238060
LDLa 1104..1140 CDD:238060
LDLa 1145..1178 CDD:238060
FXa_inhibition 1185..1221 CDD:464251
LDL-receptor class B 8 1309..1355
Vgb 1310..>1503 CDD:443399
LY 1336..1376 CDD:214531
LDL-receptor class B 9 1356..1398
LY 1380..1423 CDD:214531
LDL-receptor class B 10 1399..1445
LDL-receptor class B 11 1446..1490
LDL-receptor class B 12 1491..1531
LY 1613..1649 CDD:214531
LDL-receptor class B 13 1627..1669
LY 1650..1693 CDD:214531
LDL-receptor class B 14 1670..1713
LY 1697..1734 CDD:214531
LDL-receptor class B 15 1714..1753
LY 1734..1775 CDD:214531
LDL-receptor class B 16 1754..1798
FXa_inhibition 1850..1886 CDD:464251
YncE 1872..2084 CDD:442618
LDL-receptor class B 17 1934..1976
LY 1959..1999 CDD:214531
LDL-receptor class B 18 1977..2019
LDL-receptor class B 19 2020..2063
Ldl_recept_b 2020..2061 CDD:459654
LY 2045..2087 CDD:214531
LDL-receptor class B 20 2064..2107
FXa_inhibition 2159..2194 CDD:464251
LDL-receptor class B 21 2253..2294 3/8 (38%)
LDL-receptor class B 22 2295..2343 11/58 (19%)
LDL-receptor class B 23 2344..2388 5/43 (12%)
Ldl_recept_b 2344..2386 CDD:459654 5/41 (12%)
LY 2370..2411 CDD:214531 6/40 (15%)
LDL-receptor class B 24 2389..2431 7/48 (15%)
LDL-receptor class B 25 2432..2473 10/48 (21%)
FXa_inhibition 2482..2517 CDD:464251 10/37 (27%)
LDLa 2527..2557 CDD:238060 8/36 (22%)
LDLa 2566..2600 CDD:238060 5/33 (15%)
LDLa 2605..2639 CDD:238060 7/36 (19%)
LDLa <2666..2688 CDD:238060 2/21 (10%)
LDLa 2696..2730 CDD:238060 17/33 (52%)
LDLa 2734..2765 CDD:197566 12/31 (39%)
LDLa 2773..2806 CDD:197566 7/57 (12%)
LDLa 2817..2849 CDD:197566 6/32 (19%)
LDLa 2857..2890 CDD:197566 4/40 (10%)
LDLa 2907..2939 CDD:238060 12/31 (39%)
cEGF 2964..2985 CDD:463661
EGF_CA 2982..>3011 CDD:214542
LY 3049..3093 CDD:214531
LDL-receptor class B 26 3069..3113
LY 3094..3136 CDD:214531
LDL-receptor class B 27 3114..3156
LY 3138..3180 CDD:214531
LDL-receptor class B 28 3157..3200
LY 3182..3223 CDD:214531
LDL-receptor class B 29 3201..3243
LY 3224..3264 CDD:214531
LDL-receptor class B 30 3244..3284
FXa_inhibition 3294..3330 CDD:464251
LDLa 3334..3365 CDD:238060
LDLa 3374..3408 CDD:238060
LDLa 3413..3448 CDD:238060
LDLa 3452..3485 CDD:197566
LDLa 3493..3526 CDD:197566
LDLa 3536..3570 CDD:238060
LDLa 3575..3609 CDD:238060
LDLa 3613..3647 CDD:238060
LDLa 3653..3685 CDD:197566
LDLa 3695..3731 CDD:238060
LDLa 3746..3776 CDD:238060
YncE 3862..4064 CDD:442618
LDL-receptor class B 31 3912..3954
Recognition site for proteolytical processing. /evidence=ECO:0000255 3940..3943
LY 3955..3992 CDD:214531
LDL-receptor class B 32 3970..4012
LDL-receptor class B 33 4013..4056
Ldl_recept_b 4013..4054 CDD:459654
LY 4037..4078 CDD:214531
LDL-receptor class B 34 4057..4101
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7 4445..4544
NPXY motif 4502..4507
CG6739NP_609130.1 CRD_FZ 314..427 CDD:143549 36/184 (20%)
LDLa 432..464 CDD:238060 18/61 (30%)
LDLa 470..505 CDD:238060 14/35 (40%)
LDLa 697..731 CDD:238060 15/41 (37%)
Blue background indicates that the domain is not in the aligned region.

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