DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and LpR1

DIOPT Version :10

Sequence 1:NP_002323.2 Gene:LRP1 / 4035 HGNCID:6692 Length:4544 Species:Homo sapiens
Sequence 2:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster


Alignment Length:844 Identity:323/844 - (38%)
Similarity:447/844 - (52%) Gaps:93/844 - (11%)


- Green bases have known domain annotations that are detailed below.


Human  2518 RAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNM 2582
            :::.:.| .:.:|:|.:|:||.....|||...|||.|||:     .:.||.....||        
  Fly   130 QSLEAKC-DEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ-----IKECKFIEATCS-------- 180

Human  2583 LWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMN--CSATDCS 2645
                        ||            :|||.:|.||.|..||:|..||.|.|||.|  |.....:
  Fly   181 ------------SD------------QFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPN 221

Human  2646 SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPR-CPLNYFACPS--GR 2707
            :.|:          |:....|...||:|||:|||.|.|||..|    |.| |..:.:||.|  |:
  Fly   222 NEFK----------CQTVDQCIPRSWLCDGSNDCRDKSDEAHC----RARTCSPDEYACKSGEGQ 272

Human  2708 CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGK 2772
            |:|::|.||:..||..|.||.:||:.|...:|.|.|.|||.|:|.||..||||||||| ..|...
  Fly   273 CVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDE-KECPVV 336

Human  2773 TCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST-CDDREFMCQNR-QCIPKHF 2835
            .|...:........|:.:||:||||.||:||:||...|.....:| |...|:.|::| .|:...:
  Fly   337 PCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSW 401

Human  2836 VCDHDRDCADGSDE-SPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHC-- 2897
            :||.||||.||.|| :..|:..||...:|:|.:..|:.. ...|:|:.||.|.|||.    .|  
  Fly   402 LCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPG-HLTCNGDKDCADGSDER----DCGL 461

Human  2898 ----TSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERG--CHINECLSRKLSGCSQDC 2956
                ...:..|||:|:|.|..|:||..:.:|:.:.||.|..||..  |.||||.| |..||...|
  Fly   462 SLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECAS-KNGGCMHQC 525

Human  2957 EDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHS- 3020
            .|||:|..|.|..|::|..|.|.|.|::||.....|||.|:|..|.:||.|..||.   .||.: 
  Fly   526 IDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYM---RDPKNH 587

Human  3021 --CKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMI 3083
              ||| ::....|:.|.|:.:||:.||....|.:......|.||||.:|..||:|:|||||....
  Fly   588 TRCKA-SEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYK 651

Human  3084 RRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPR 3148
            ..:........||.::.::: |||||||:..::|:.|..:.|||::...|:...|||...|..||
  Fly   652 APIDEGNEKTVVLTKSSVTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPR 715

Human  3149 ALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYI 3213
            ::.:|...|::||:|||....|.|.|||||.|:.|:...:.||||:|||.|.:||||.|.:.:.|
  Fly   716 SIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVI 780

Human  3214 EFASLDGSNRHVVL--SQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG--TNKTLLISTLHR 3274
            ..|:.|||.|..||  .:.:.|.|::|.|||.||||||:.:::.:|:|.||  ......:..|..
  Fly   781 SSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQH 845

Human  3275 PMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHK-----CACPTNFYLGSDGRTCVSN 3333
            ||.:||:|..||||..|| |:..||.||:|||.:|....:     |||||...|..||..||.:
  Fly   846 PMVVHVYHPYRQPDGVNH-CQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVED 908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_002323.2 LDLa 26..59 CDD:197566
Ldl_recept_a 71..104 CDD:395011
FXa_inhibition 119..148 CDD:464251
FXa_inhibition 158..188 CDD:464251
LY 275..314 CDD:214531
LDL-receptor class B 1 292..334
LY 316..358 CDD:214531
LDL-receptor class B 2 335..378
LY 361..401 CDD:214531
LDL-receptor class B 3 379..422
FXa_inhibition 486..519 CDD:464251
LY 551..593 CDD:214531
LDL-receptor class B 4 571..613
LY 594..633 CDD:214531
LDL-receptor class B 5 614..659
LY 640..689 CDD:214531
LDL-receptor class B 6 660..710
LY <700..733 CDD:214531
LDL-receptor class B 7 711..754
FXa_inhibition 807..842 CDD:464251
LDLa 853..885 CDD:197566
LDLa 895..928 CDD:238060
LDLa 935..967 CDD:197566
LDLa 978..1011 CDD:238060
LDLa 1015..1048 CDD:238060
LDLa 1062..1097 CDD:238060
LDLa 1104..1140 CDD:238060
LDLa 1145..1178 CDD:238060
FXa_inhibition 1185..1221 CDD:464251
LDL-receptor class B 8 1309..1355
Vgb 1310..>1503 CDD:443399
LY 1336..1376 CDD:214531
LDL-receptor class B 9 1356..1398
LY 1380..1423 CDD:214531
LDL-receptor class B 10 1399..1445
LDL-receptor class B 11 1446..1490
LDL-receptor class B 12 1491..1531
LY 1613..1649 CDD:214531
LDL-receptor class B 13 1627..1669
LY 1650..1693 CDD:214531
LDL-receptor class B 14 1670..1713
LY 1697..1734 CDD:214531
LDL-receptor class B 15 1714..1753
LY 1734..1775 CDD:214531
LDL-receptor class B 16 1754..1798
FXa_inhibition 1850..1886 CDD:464251
YncE 1872..2084 CDD:442618
LDL-receptor class B 17 1934..1976
LY 1959..1999 CDD:214531
LDL-receptor class B 18 1977..2019
LDL-receptor class B 19 2020..2063
Ldl_recept_b 2020..2061 CDD:459654
LY 2045..2087 CDD:214531
LDL-receptor class B 20 2064..2107
FXa_inhibition 2159..2194 CDD:464251
LDL-receptor class B 21 2253..2294
LDL-receptor class B 22 2295..2343
LDL-receptor class B 23 2344..2388
Ldl_recept_b 2344..2386 CDD:459654
LY 2370..2411 CDD:214531
LDL-receptor class B 24 2389..2431
LDL-receptor class B 25 2432..2473
FXa_inhibition 2482..2517 CDD:464251
LDLa 2527..2557 CDD:238060 13/29 (45%)
LDLa 2566..2600 CDD:238060 6/33 (18%)
LDLa 2605..2639 CDD:238060 17/35 (49%)
LDLa <2666..2688 CDD:238060 13/21 (62%)
LDLa 2696..2730 CDD:238060 15/35 (43%)
LDLa 2734..2765 CDD:197566 18/30 (60%)
LDLa 2773..2806 CDD:197566 12/32 (38%)
LDLa 2817..2849 CDD:197566 14/33 (42%)
LDLa 2857..2890 CDD:197566 11/32 (34%)
LDLa 2907..2939 CDD:238060 12/33 (36%)
cEGF 2964..2985 CDD:463661 8/20 (40%)
EGF_CA 2982..>3011 CDD:214542 12/28 (43%)
LY 3049..3093 CDD:214531 15/43 (35%)
LDL-receptor class B 26 3069..3113 17/43 (40%)
LY 3094..3136 CDD:214531 15/41 (37%)
LDL-receptor class B 27 3114..3156 13/41 (32%)
LY 3138..3180 CDD:214531 20/41 (49%)
LDL-receptor class B 28 3157..3200 22/42 (52%)
LY 3182..3223 CDD:214531 19/40 (48%)
LDL-receptor class B 29 3201..3243 18/43 (42%)
LY 3224..3264 CDD:214531 18/43 (42%)
LDL-receptor class B 30 3244..3284 16/41 (39%)
FXa_inhibition 3294..3330 CDD:464251 17/40 (43%)
LDLa 3334..3365 CDD:238060 323/844 (38%)
LDLa 3374..3408 CDD:238060
LDLa 3413..3448 CDD:238060
LDLa 3452..3485 CDD:197566
LDLa 3493..3526 CDD:197566
LDLa 3536..3570 CDD:238060
LDLa 3575..3609 CDD:238060
LDLa 3613..3647 CDD:238060
LDLa 3653..3685 CDD:197566
LDLa 3695..3731 CDD:238060
LDLa 3746..3776 CDD:238060
YncE 3862..4064 CDD:442618
LDL-receptor class B 31 3912..3954
Recognition site for proteolytical processing. /evidence=ECO:0000255 3940..3943
LY 3955..3992 CDD:214531
LDL-receptor class B 32 3970..4012
LDL-receptor class B 33 4013..4056
Ldl_recept_b 4013..4054 CDD:459654
LY 4037..4078 CDD:214531
LDL-receptor class B 34 4057..4101
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7 4445..4544
NPXY motif 4502..4507
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 13/32 (41%)
LDLa 178..210 CDD:197566 18/63 (29%)
LDLa 219..254 CDD:238060 15/44 (34%)
LDLa 259..295 CDD:238060 15/35 (43%)
LDLa 343..373 CDD:238060 13/29 (45%)
LDLa 383..415 CDD:197566 13/31 (42%)
Ldl_recept_a 423..459 CDD:395011 13/40 (33%)
LDLa 476..504 CDD:197566 10/27 (37%)
FXa_inhibition 514..549 CDD:464251 16/35 (46%)
EGF_CA 551..581 CDD:214542 13/29 (45%)
LY 662..702 CDD:214531 15/40 (38%)
LY 704..747 CDD:214531 20/42 (48%)
LY 749..790 CDD:214531 19/40 (48%)
Ldl_recept_b 769..815 CDD:459654 20/45 (44%)
FXa_inhibition 864..905 CDD:464251 17/40 (43%)
Blue background indicates that the domain is not in the aligned region.

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