DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP1 and lrp-2

DIOPT Version :9

Sequence 1:XP_016874792.1 Gene:LRP1 / 4035 HGNCID:6692 Length:4561 Species:Homo sapiens
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:5100 Identity:1514/5100 - (29%)
Similarity:2276/5100 - (44%) Gaps:935/5100 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    22 DAP----KTCSPKQFACRDQITCISKGWRCDGERDC---PDG----SDEAPEICPQSKAQRCQPN 75
            |.|    :||...:|.|:.. .|:.:|:.||.:.||   |:|    ||||||:|.|  ...|..|
 Worm    72 DEPSTCKRTCLENEFVCKTG-KCLPRGYLCDSQYDCGRLPNGDRDLSDEAPELCNQ--PLHCDYN 133

Human    76 EHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
            |:.|..:..|||:.:.|:|.:||.|||||...| .::...:...|::....|:||..|||..:..
 Worm   134 EYACSKSAQCVPLFKFCDGKRDCSDGSDEHSMC-HVEDPKTADSCEYGAAMTIDGIKCYCPKNKF 197

Human   141 LQADGKTCKDFDEC-----SVYGTCSQLCT-NTDGSFICGCVEGYLLQPDNRSCKA-KNEPVDRP 198
            |...|| |:..:.|     .:...|||.|| |.:|:|.|.|.:..|...:...|.| |::.:...
 Worm   198 LNEQGK-CEFVNHCERTKNGLPPVCSQDCTDNKNGTFTCSCFDPRLTVVNGTHCVADKDQTIPSV 261

Human   199 PVL----LIANSQNILATYLSGAQVSTITPTSTRQTTAM-------DFSYANETVCWVHVGDSAA 252
            .:|    |....:|.:::|.|       .|....:..||       ||..|...:..:....||.
 Worm   262 AILTKKKLFVLQKNKMSSYSS-------MPRPLGKPGAMTLVIQHPDFPEATVPILCLSESPSAN 319

Human   253 QTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNG---DTC 314
            .:.:.|..:.|.:.....:.|:..||..|:  :..|.:..|:.|. |....:|:|..|.   .:|
 Worm   320 DSYITCGNVEGSEPATKTYAIDFDLSSIHI--IRFDNIGNNWIFT-DASYYVFICKHNSVRISSC 381

Human   315 VTLLDLELYNPKGIALDPAMGKVFFTDYGQIPK-VERCDMDGQNRTKLVDSKIVFPHGITLDLVS 378
            .|:...::...:.:..|...|::..::...:.: :.|.|:....|.:|....|..| .:.:|..:
 Worm   382 RTVTAGDMGTIQDMKYDGLNGQLLVSEVDVLQQGIWRIDVASGQRYRLSYQPITSP-ALAIDPFT 445

Human   379 RLVYWADAYLDYIEVVDYEGKGRQTIIQG------ILIEHLYG---LTVFENYLYATNSDNANAQ 434
            ..:|:.|.....|:.|||.....:||:.|      .:|::..|   ||:.:|.::|.|:.::|:.
 Worm   446 ETLYFVDIGARSIKAVDYNANYSRTIVSGRIAKEVKMIDYAEGRLFLTLKDNRVFAMNALDSNSD 510

Human   435 QKTSVIRVNRFNSTEYQVVTRVDKGG-----ALHIYHQRRQPRVRSHACEN--DQYGKPGGCSDI 492
            .|.            :|.||...|.|     .|.:.|.||    ..||.:|  ....|...|.|:
 Worm   511 MKI------------WQEVTPQRKQGNENIQILEVLHFRR----NEHAWKNKGKNICKAAMCDDM 559

Human   493 CLLANSHKARTCRCRSGFSLGSDGKSCKK--PEHELFLVYGKGRPGIIR--GMDMGAKVPDEHMI 553
            | :.:.::..:|.||.|:...:...|..|  .:.||| |..:.||..|:  |.|...:.   .:|
 Worm   560 C-IGHINQTSSCFCRDGYIQNNTKCSASKDLKDEELF-VLAQLRPSRIKILGFDKNYRT---EII 619

Human   554 PIENLMN---PRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDN 615
            .:.:|:|   |.|:.|..:...:...|...:.:..|||..|........||.|.||:|.|:..||
 Worm   620 GVSDLLNVKRPSAMTFDPKGEQLLMYDLRRHSLVVQKIGSTNYTVHGLTGIMNCEGMAYDFTSDN 684

Human   616 LYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRR--GR 678
            ||.||. .:|.|:|.||...: .:|.::.|.|::||||.:.....:::|..|.||..|..:  ..
 Worm   685 LYMTDQ-RRKIITVQRLSNLS-IQKVVVSGNMSNPRAIAIHIAKSYLFWGSWNEDNNDDEKIPAM 747

Human   679 LERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPE-L 742
            :||:.:|||.|...| ||..:|.|||:||:....|||.||:.:.||.|..||.||::|..|.: :
 Worm   748 IERSKLDGSERKTLV-SKNAMWINGLTLDLKNDYLYWCDAYRNVIERIRWNGADREVVVHGADKI 811

Human   743 NHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKC 807
            :|.:||....|::|:||::.|:|.|:....   |..|..:......:||:.::.....:. |:.|
 Worm   812 SHPYGLAFFDNHIFYTEFKKGAVKRVNVDF---PDDVQEVFQYSATVFELLVFKNSNPET-TSPC 872

Human   808 RVNNGGCSSLCLAT--PGS-----RQCACAEDQVLDADGVTCLANPSYVPPPQCQPG-EFACANS 864
            ..::..|...|.|:  .||     .:|.||:...:..:| .|:.:..:|.|..|... ||.|.||
 Worm   873 STSSNICEHFCFASSCKGSVGCEPVKCGCADGMKVLKNG-KCVKDEEWVDPNACDNEIEFTCLNS 936

Human   865 -RCIQERWKCDGDNDCLDNSDE-APALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDES 927
             :|:.:...||||:||.|.||| |..:|..:.|..::|:|:...|:|..::|||.:||.:..||.
 Worm   937 KKCVPKSNLCDGDDDCGDGSDEDANGICKDYKCVGNKFQCDGTTCLPMEFICDGKSDCYDGTDEL 1001

Human   928 NATCSAR---TCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRC 989
            ...|...   .|..:||.|:..:||..|..|:...:|.:.:||........|.| .:|.|..|.|
 Worm  1002 EKICKKAPIVKCSVSQFQCSKTKCIIKSKRCNGVQECDNGADEEDCPRSKLCDP-DEFRCGTGLC 1065

Human   990 ININWRCDNEKDCGDGSDEQTCPEPADNDCGDNSDEAGCSHSCSSTQFKCNSGR--CIPEHWTCD 1052
            |..:..||.:..|.||.||:.|           ::|..|   ....||:|.:|:  |:...:.||
 Worm  1066 IKQSQVCDGKMQCLDGLDEEHC-----------NEEEKC---LQGRQFRCANGKSTCLDLIFRCD 1116

Human  1053 GDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGV 1117
            |..||.|.|||:...|...::...|  ..::|.| .||.|:.....|||..||:...||..|.  
 Worm  1117 GVADCEDSSDESDEFCKGNSSSTCG--KMNQFMC-ADGKCLRSFQLCDGFPDCLTGEDETECP-- 1176

Human  1118 THVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC-------ESLACRPPSHPCANNTSV 1175
            ..:||.:....|.:..:||||...|||.:||.|||||::|       .:|.|:.|.:.|......
 Worm  1177 PSMCDSTTHLSCLNGQKCISKQLECDGVDDCGDNSDEKHCTEIRLDEAALRCQSPMYQCDGPNFK 1241

Human  1176 CLPPDKLCDGNDDCGDGSDEGELCD-QCS-LNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTC 1238
            |:....||||.:||.:|.|||..|. .|: .::.||||.|...| .|.:||||....|..:..||
 Worm  1242 CISDKHLCDGTNDCEEGDDEGLWCTFNCTDADDLGCSHTCRPTP-VGPICSCPDDHYLDKNGVTC 1305

Human  1239 QIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHK 1303
            ..:..| :..:|||.|..:..|..|.|.:.:.|..|..||.|.||.|||:|:|||||||.|....
 Worm  1306 SKKDPC-RFGQCSQYCSPHGSSHFCYCEDSFKLGADRSSCISDDPRKPFLIYSNRHEIRMIQSKY 1369

Human  1304 GDYSVLVPGLRNTIALDFHLSQS---ALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEG 1365
            .....::..|.|.|||||...|:   ::||||:..||||.| |:|...:.....::.||:...||
 Worm  1370 PGSLPMITNLVNAIALDFKYHQNGSVSIYWTDLSADKIYTG-LVDQRTILYQRTIVSYGVFNAEG 1433

Human  1366 LAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRI 1430
            :|||||:|||||::|.||.|:|...|||.|.|::..::.:.|::|:|..:|.:|||||:.|.|||
 Worm  1434 IAVDWISGNIYWIDSFLDTIQVVSEDGTKRATVINQNMGNARSLAIDVEEGFMFWTDWEESNPRI 1498

Human  1431 EAASMSGAGRRTVHR--ETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHE 1493
            |.||::|..|..:.:  .....|||||:.:|.:.||:.|.||:||:|::..|||..|:.|.|..|
 Worm  1499 ERASLAGNNRAIIWKISNIAQAGWPNGIALDTIAKRVYWADAKSDSIHTITYDGRDHVIVFRDPE 1563

Human  1494 FLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPM-APNPC 1557
            .|.|.|.:.:|.|.||::||||||::|.:||.|.||::::|..||||.|::.|.|:|.| ..|.|
 Worm  1564 RLGHCFGIDVYEGHVYFSDWRTNTISKVDKWFGSNVSIIERVATQPFSLKIVHRSKQKMQIKNSC 1628

Human  1558 EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNY 1622
            :.    ..|:.:||.|.....:|.|.:|.....|.  |.:.::.||.|.:..:||...|.|:.:.
 Worm  1629 DG----FKCNGICLNNGKNKATCQCTNLQSTTDDG--CVDIQQVLLVATKNGVRGFSTDPPHPHA 1687

Human  1623 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVS--ADLPNAHGLAVDWV 1685
            ....:....:|:..:  .:...|:...|..|..|....:.||..:.|::  :||....|:|||.|
 Worm  1688 FPLVSGKQYENIRAV--GSFNNRLQVLDDYTTHIATVNLTGTADDGVLATGSDLYGVSGMAVDPV 1750

Human  1686 SRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-----LEQPHGLVVHPLRGKLYWTD-------- 1737
            ..:.:.|........:.|...||..:..:.:.     ::.|..::.  :..||:|.:        
 Worm  1751 VGSTYITLSIDGVGSVEVISADGKSRRVLAESSSSNPMKLPRDILF--MNTKLFWFEDSTSPPSI 1813

Human  1738 ------GDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSG--------NHTINRCNL 1788
                  ||::....:   |.||| :....|   .:|...||:||||.|        :..:....:
 Worm  1814 FSMSAAGDDLKKLKV---NSTLL-NKFYNP---TVDRFYSKIYWISQGKVIQFDPKSEVVQEIQI 1871

Human  1789 DGSGLEVIDAMRSQLGKATALAI--------MGDKLWWADQVS-EKMG-TCSKADGSGSVVLRNS 1843
            .|..           |..:::|:        :|:.:..|:|.: .::| ..:||...|||:|   
 Worm  1872 PGGD-----------GNVSSIAVDMTNGDILIGEFIRIANQTTIRRLGMKGTKAIQRGSVML--- 1922

Human  1844 TTLVMHMKVYDESIQLDHKGT-NPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVG 1907
            ..|...:|.:..::.:..|.. :.|.    .|..|||.:|:....|:|:.|:.|.:|:  |....
 Worm  1923 VPLHSSIKFFLSTVDITAKNVPDECK----KCPSLCLRSSDKKFQCVCSQGFELVNGK--CRSPD 1981

Human  1908 SFLLYSVHEG-IRGIPLDPNDKSDALVPV---------SGTSLAVGIDFHAENDTIYWVDMGLST 1962
            ..:.::..:| :..:....|.|:..|:..         .|....:.:...|:||.:|.|      
 Worm  1982 KRVFFATDDGSLHSVGWYKNSKTGDLIQKYRAHSLHSDIGKKRILKLVADAKNDLVYVV------ 2040

Human  1963 ISRAKRDQTWREDVVTNG----------IGRVEGIAVDWIAGNIY------WTDQGFDV-IEVAR 2010
               .::::.|:  ..|||          ..|:..|.:|.:.|.:.      .:.:||.| |:..|
 Worm  2041 ---TRQNEVWK--CATNGSFAHIVYSTNSHRIAAITLDRVTGYLLVSARESISPKGFIVLIDPDR 2100

Human  2011 LNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTE-RVVLVNVSISWPNGI 2074
            .:.:...|::......|..|.|.|.||.||   |.....|:.|...||| :.::...|||   .|
 Worm  2101 HSEAIHQVIVEDEDKIPYEIAVDPPKGKLF---WASSSCIKSSNYYGTEAKCIVSKSSIS---AI 2159

Human  2075 SVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFI---------YWSDR 2130
            ::|....:|.:.|:....::.:|. .|.|.:     .|:.||......|.:         |:.|:
 Worm  2160 AIDENRSRLCFVDSEKAAVDCVDY-NGNNEQ-----RNVAMFKAQPMGDIVSLVFNGDEMYFFDK 2218

Human  2131 THANGSIKRG--SKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGT---------------NVCAV 2178
            .:::|||.||  .:|.:           |.|||..|....|||..               ..|:.
 Worm  2219 FNSSGSIVRGLVQQDGS-----------VVLKDSLVKVHPRQKIRVIDFDVMDVKSSVLFTACSN 2272

Human  2179 ANGGCQQLCLYRGRG-----QRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2238
            .||||:.||:.....     ::.|.|.|....::| ||.....::.::..|.::.:. :...:|.
 Worm  2273 NNGGCEHLCITTPSENSPTVRKECLCVHSTRLDNG-SCGSSDSFIAFTRFTSIEFLS-TKPGDLT 2335

Human  2239 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVE 2303
            :|.:.......:.:.|.      |.|:..|..||:|:|.....|..:|.||:..:.|.|:||.|.
 Worm  2336 SPNKQITSNGCVMSKIG------AVTADATRGRIYFADYDKFRITAVNFDGTGCVVIAEDVGVVP 2394

Human  2304 GLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAF--ERETVITMSGDDHPRAFVLDECQNLMFWT 2366
            .:||......||:.....::|.|..|......::  |.:.|:|::..|.||...:..|:.|:|:|
 Worm  2395 SMAYDEVHTELYFVRANPASIWRINVADNNLESYPTEPKIVLTLTVRDRPRHIAIHPCRMLLFFT 2459

Human  2367 NWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVI 2431
            |.......|.|...||.....::::|:....||.||..:|||||||:...||.||::|||||.::
 Worm  2460 NNAITGSVIERVYFSGFKRDQIVQEDLHDLRGLTIDLDSEKLYFSDSKDFKISRCDFDGSHRELV 2524

Human  2432 LKS---EPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLR--VDIPQQPMGIIAVANDT 2491
            :.:   ..:|||.|::|.:.|.:||||||:|...||..||:.:.:.  .|:   |:|::.|....
 Worm  2525 VSNTDIPSIHPFELSIYDDEIIFTDWVRRSVVGVNKITGSDNRNINRATDV---PVGLVVVDTKR 2586

Human  2492 NSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRIL-QDDLTCRAV--NSSCRAQDEFECANGE 2553
            ..|....|..|...|:|.|.|...|..:|:|.|.|.| .|:.||...  ...| |::||:|.:.:
 Worm  2587 EYCTSDACADNELKCEDYCRLMANGQASCACNGERRLNSDNRTCTGEFDGKKC-AENEFKCLHSD 2650

Human  2554 -CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC 2617
             ||.:..|||....|....||...||::|.|:..:..|.||.|:.....||..:||.:.:||..|
 Worm  2651 RCIRYEDTCDRYNDCPMFDDEDTKYCSTRVCRPGYFNCGNGLCIPEQKVCNRINDCANFADESNC 2715

Human  2618 NKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSL 2682
               .|...||||:.|.||.:.:|||...||.|||||:.|...:||:....|:.|::  .|..||.
 Worm  2716 ---TCNENEFRCQSGACIPSKARCNHMQDCNDASDEIGCPFRNCSALNEFGMTGLI--NCATTSQ 2775

Human  2683 CYAPSWVCDGANDCGDYSDERDC--------PGVKRPR-CPL-NYFACPSGR-CIPMSWTCDKED 2736
            |..|||.|||.|||.|.|||:||        ..|..|| |.. ..|||.:.| |:|..|.||.:.
 Worm  2776 CIHPSWKCDGTNDCYDGSDEKDCFVEFDATGGSVSAPRSCDAKTQFACLATRTCMPKHWQCDGQP 2840

Human  2737 DCEHGEDETHCN-KFCSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDE---AAHCEGKTCGPSSF 2796
            ||..|.||.:|: |.|:..:|.|: :.:||..:..|||..||.||.||   ...|:.|. |.::|
 Worm  2841 DCADGSDEKNCDAKKCTSFEFSCESSKKCIPLEQKCDGRRDCPDGEDEHQCETECDSKG-GNATF 2904

Human  2797 SCPGTHVCVPERWLCDGDKDCAD-----GADESIAAGCLYNSTCDDREFMCQNRQCIP----KHF 2852
            .|. .|.|:|..|.|||..||.|     |:||   ..|....|.......|.:..|:.    ...
 Worm  2905 RCT-NHRCIPMAWRCDGTDDCMDNAKSLGSDE---VDCAAGRTSFHVPSRCADETCVVACELTAV 2965

Human  2853 VCDHDRDCADGSDESPECEY--PTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCT 2915
            :||..:||:||.||. .|..  ..|.|:|:.|.:|:|:.|.:. ||...||.|.|||..:  .|:
 Worm  2966 LCDGIQDCSDGFDEK-NCASLDRQCKPNEWMCDSGQCIDSGRL-CDASVDCVDGSDEWVE--ICS 3026

Human  2916 SQE---HKCNASSQFLCSSGR--CVAEALLCNGQDDCGDSSDERGCH--INECLSRKLSGCSQ-- 2971
            ..|   ..|.:....|.::|.  |:.|..||:|:.||....||: |.  ...|.|.: :.|.|  
 Worm  3027 LSEPPRRGCPSGWSCLLTNGTIGCLQEQQLCDGRRDCMSGIDEQ-CDNPQGNCSSTR-NSCDQTW 3089

Human  2972 DCEDLKIGFK-CRCRPGFRLKD-DGRTCADVDECSTTFPCSQRCINTHG-SYKCLCVEGYAPRGG 3033
            :|: ...||: |.|..|:.|.. |.:||.....|... .||..||:... .::|.|..||. ...
 Worm  3090 NCQ-RHAGFESCSCDDGYHLSPYDKKTCLRSPSCPKA-NCSHFCIDRRDVGHQCFCAPGYI-LSE 3151

Human  3034 DPHSCKA--VTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQ 3096
            :...|:.  ..:.|..:::.:|  |:...:||.....|...|.|.||||:|.:..::|||||...
 Worm  3152 NQKDCRRNDTIEAEILMVYGHR--LKLFTIDGHAKATLLSNLTNGVALDYDVKSDLVYWTDVAHD 3214

Human  3097 GSM--IRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAY-RTVLVS 3158
            |:.  |..|....:..:|::.......||:||||:|.|:|:.|:..|.|.|..:.|.: |.:|..
 Worm  3215 GNKAGITSMSNQPNTYRVINSLPTKGIDGIAVDWLGRNIYYTDRNHDAIAVCDMRGRFNRILLKG 3279

Human  3159 SGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIV-DTKITWPNGLTLDYVTERIYW 3222
            :.|.:|||:|:|.....::|||||..:.|||:.||||:..||: |..|.|||.|.:|...:|:|:
 Worm  3280 TPLNDPRAIVLDPLQALVFWTDWGASAHIGRMNMDGSNEQVILQDRTIRWPNALAVDAPAQRLYF 3344

Human  3223 ADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLI- 3286
            .||..|||...:.|||.|.:||...:.|||||.:|||||||:||...:|.|.||.||||:.:|| 
 Worm  3345 GDAHRDYIASCNYDGSKRRMVLRGSVRHIFALAVFEDYVYWSDWHNHTIERVHKITGTNRKVLIQ 3409

Human  3287 STLHRPMDLHVFHALRQP----DVPNHPCKVNNGGCSNLC-------LLSPGGGHKCACPTNFYL 3340
            ...:|||...:.|...|.    ....|||. ....|.|||       |.:......|.|...|  
 Worm  3410 DKQYRPMGFKIVHPSLQSMGSLKTARHPCS-QPARCDNLCIPANTPDLTTSSDNFTCMCAQGF-- 3471

Human  3341 GSDGRTCVSNCTASQFVC-KNDKCIPFWWKCDTEDDCGDHSDE----PPDCPEFKCRPGQFQC-- 3398
            .|:||:|||.|..:.||| |..|||..||:||.:|||||..||    ...||.|.|..|||.|  
 Worm  3472 RSEGRSCVSECKPNDFVCTKTYKCISSWWRCDGQDDCGDGEDEGYFVEGVCPPFPCIAGQFVCGR 3536

Human  3399 ----STGICTNPAFICDGDNDCQDNSDE--ANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCG 3457
                :|..|...:.:|||..||....||  |.|:...|..:||||.:..:|||....|:.:.:|.
 Worm  3537 TAQNATAQCLYASKLCDGVKDCSGGDDEEPAFCENFECTEAQFKCGDKKKCIPLTSVCDKEKDCD 3601

Human  3458 DGEDERDCPEVTCAPNQFQC---SITKRCIPRVWVCDRDNDCVDGSDEPANCTQM-TCGVDEFRC 3518
            ||.||.:|...:|.|:.|.|   :...:|||:.:.||.::||.:|.|||.:|..: .|..::|:|
 Worm  3602 DGSDELNCEITSCKPDFFACFNGTAISKCIPKEFYCDGEDDCPEGQDEPDSCFGIGECTHEQFQC 3666

Human  3519 KDSGRCIPARWKCDGEDDCGDGSDEP--KEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDN 3581
             .||:|||.|.:|||..||.|||||.  |:|| ...|:        |.||.....||....|.|.
 Worm  3667 -TSGKCIPKRRQCDGTLDCRDGSDEKGCKKEC-AIVCD--------NSCVHADDLCDGKKKCNDG 3721

Human  3582 S--DEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIP 3644
            |  |||:|..:...|.|    |.:|  |.:.|||..||.||||||.|.   |::.....:...| 
 Worm  3722 SDEDEEACVIKQLLEKE----NRKC--GGFACDGIVDCEDGSDEKGCP---DLECHLASNKSLI- 3776

Human  3645 LRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWK-CDGEDDCGDNSDENPEECA 3708
                ||...||..|.||..|.....:   :.|||:....|  .|: |||..||.|..||:||.||
 Worm  3777 ----CDGTIDCSSGKDENNCHNNGES---NFFQCSMQTIK--EWQVCDGRWDCADGLDESPEMCA 3832

Human  3709 RFVCPPNRPFR---CKNDRVCLWIGRQ-CDGTDNCGDGTDEEDCEPPTAHTTHCKD--KKEFLCR 3767
               ....|.||   |.:.:.||.:... |||..:|.||:||        :..||||  |.::.|.
 Worm  3833 ---SRKARCFRIGYCDDKKQCLDVSTALCDGIRDCFDGSDE--------NPIHCKDMCKGKYRCT 3886

Human  3768 NQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHT 3832
            |.||:..|.||:..|||||||||:.|..                                     
 Worm  3887 NGRCIDVSARCDGRDDCGDGSDEDTCGA------------------------------------- 3914

Human  3833 VPGQPGCQDINECLRFGTCSQLC----NNTKGGHLCSCARNFMKT---HNTCK--AEGSEYQVLY 3888
                       ||..||.|:|.|    |:|.   .|.||..:.:|   .|.|:  ::.:|   ::
 Worm  3915 -----------ECHHFGVCAQKCWMAFNHTA---RCHCAPGYARTKNDENECEPLSKSAE---MF 3962

Human  3889 IADDNEIR--------------------SLFPGHPHSAYEQAFQ-------GDESVRIDAMDVHV 3926
            |.:.|.:.                    :|.||.....|: .|:       |..:.|:|      
 Worm  3963 ITNGNRLHLMSLENSQVSVLRPVFNIKMNLIPGGIDFGYD-VFRTTLMYTVGIGNSRVD------ 4020

Human  3927 KAGRVYWTNWHTGTI-SYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVY 3990
                :....|..|.| |:......|                      ||     |..|::..|||
 Worm  4021 ----IRSKKWSDGLIGSWGEEESTA----------------------GL-----ITYDFMHNNVY 4054

Human  3991 WTDS---GRDV-------IEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIET 4045
            :|:|   .|.|       |.||:.|..:.:|||.......:::.|||::..::|:.....|:|.:
 Worm  4055 FTESSEQNRGVLFDRQANIYVAKAKDTSTRTLIVNSTGTINSLAVDPIKRLIFWTTSAPVPRILS 4119

Human  4046 AAMDG-----------TLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVA 4099
            |.:||           ...:.||:.||..||.:.:|:.||||||.|.....|.::..:|.|....
 Worm  4120 ANLDGKPIAQPFKTGSQPHKALVERNIFEPTSMVLDFSNERLYWIDVLKRTIETVSFDGRDRRTV 4184

Human  4100 ADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGH------------SPLVNLTGGLSH-AS 4151
            ...:.| ..|.::||...|||.:|. ...:.::|||..            ||.:.:.  ::| |.
 Worm  4185 RKFELG-DTPVTMDVLGGYIYLITR-QGSIHRMHKFTGKTNKYVQKIREVSPRIQIR--VAHPAK 4245

Human  4152 DVVLYHQHKQPEVTNPC-----------------------------------DRKKCEWL----- 4176
            ..|.:..|::    |||                                   ..|||..|     
 Worm  4246 HTVSHITHQK----NPCQSDYCPSNTVCVPDQDKNGILIPKCLCGPGRFFEVSTKKCMQLREKDQ 4306

Human  4177 ---------------------CLLSP------------------------------SGPVCTCPN 4190
                                 |:..|                              :..||.||:
 Worm  4307 EASQCGDYFCYNNAGCSPQKTCVCPPGFYGRQCEINECSETCWNGETCAVQEFGSTTNVVCHCPS 4371

Human  4191 ----------------GKRLDNGTCVPVPSPTPPP-----------------------DAPRPGT 4216
                            |.|   |:|..||.|...|                       ||.   .
 Worm  4372 NYTQSSCATNVCEGVCGPR---GSCKTVPCPKDEPHCRSYSFCECDKGWTGPHCRHKADAK---V 4430

Human  4217 CNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEH-CRNGGTC--AASPSGMPTCRCPTG 4278
            |...||:||:|........:|.|....||::|:  .|..| |.|||.|  |.|...:|.|.||:|
 Worm  4431 CYGHCFSGGACDGEGPLNLRCSCGDGLTGNRCQ--NCVGHECLNGGFCSYANSNRSLPHCICPSG 4493

Human  4279 FTGPKCTQQVCAGYC--------------------------ANNSTCTVNQGNQP---------- 4307
            |||..|.:.:|...|                          |:|:.|:.....||          
 Worm  4494 FTGDHCEEYLCKDACPFGSKCTYDITKPMDPITCSCEQNAAAHNTDCSPICQKQPNWCHNGGRCL 4558

Human  4308 -------QCRCLPGFLGDRCQYR-QCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCE-VNKCSR 4363
                   :|:|||.|.|.||... ||..||.|...|.:......:|.|...|:|.||| ..|||.
 Worm  4559 DTPGYPGKCKCLPRFAGPRCDVPVQCDDYCTNNSKCTITNGTHFECDCKPGFKGLRCEQETKCSE 4623

Human  4364 CLEGACVVNKQSGDVTCNCTDG---------------------------------RVAPSCL--- 4392
            |...|..:.|.||.|.|.|..|                                 |.:|:||   
 Worm  4624 CSNEAKCIKKPSGTVICQCPQGLGGEYCEKITATSCHQLECKNGGYCLKPDPSANRTSPTCLCSP 4688

Human  4393 ----------TCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCE----EH--VFSQQQPGHIASI 4441
                      .|...|.:.|:||::....|:|:|.....|.||:    :|  :||....|.|.|.
 Worm  4689 GFKGLLCSSNACENFCLHDGNCTLDEYFEPQCECYQAFIGDRCQYRIHQHAVIFSDDDSGWIKSF 4753

Human  4442 LIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTN-GAMNVEIGNPTYKMYEGG--------- 4496
            ::..::|:.:|:|.|:......|....:.|:|..:.| ||...:..||.|.:.|||         
 Worm  4754 VVLAIILVTIVIVVGIFANRSNRFAVFRQFRHNPLQNQGAPVDQFSNPAYLIDEGGIELVTQNTS 4818

Human  4497 --EPDDVGGLLDADFALDPDKPTNFTNPVY 4524
              ...|.|               :|.|||:
 Worm  4819 LVSSHDRG---------------SFNNPVF 4833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1XP_016874792.1 None
lrp-2NP_491270.2 LDLa 80..119 CDD:197566 13/39 (33%)
LDLa 130..162 CDD:197566 14/31 (45%)
LY 668..702 CDD:214531 18/34 (53%)
LY 707..758 CDD:214531 17/50 (34%)
LY 759..801 CDD:214531 19/42 (45%)
LDLa 968..1000 CDD:197566 10/31 (32%)
LDLa 1013..1047 CDD:238060 11/33 (33%)
LDLa 1053..1087 CDD:238060 14/34 (41%)
LDLa 1098..1129 CDD:238060 14/30 (47%)
LDLa 1144..1175 CDD:238060 12/31 (39%)
LDLa 1182..1216 CDD:238060 15/33 (45%)
FXa_inhibition 1276..1305 CDD:291342 12/29 (41%)
LY 1421..1463 CDD:214531 22/41 (54%)
LY 1465..1508 CDD:214531 18/42 (43%)
LY 1521..1555 CDD:214531 17/33 (52%)
LY 2480..2521 CDD:214531 19/40 (48%)
LDLa 2681..2715 CDD:238060 11/33 (33%)
LDLa 2717..2751 CDD:238060 18/33 (55%)
LDLa <2774..2798 CDD:238060 15/23 (65%)
LDLa 2819..2851 CDD:238060 14/31 (45%)
LDLa 2856..2891 CDD:238060 14/34 (41%)
LDLa 2904..2938 CDD:238060 15/37 (41%)
LDLa 2988..3020 CDD:197566 13/32 (41%)
LY 3231..3270 CDD:214531 14/38 (37%)
Ldl_recept_b 3296..3336 CDD:278487 20/39 (51%)
LY 3319..3362 CDD:214531 19/42 (45%)
LY 3363..3404 CDD:214531 23/40 (58%)
LDLa 3481..3514 CDD:197566 17/32 (53%)
LDLa 3574..3609 CDD:238060 14/34 (41%)
LDLa 3614..3649 CDD:197566 12/34 (35%)
LDLa 3659..3693 CDD:238060 19/34 (56%)
LDLa 3881..3912 CDD:238060 16/30 (53%)
LY 4084..4125 CDD:214531 11/40 (28%)
LY 4139..4181 CDD:214531 16/41 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 100 1.000 Domainoid score I4834
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46025
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 1 1.000 - - FOG0002316
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1742
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.690

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