Protein Alignment AcCoAS and ACS1

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_009347.1
• Gene: ACS1 / 851245
• SGDID: S000000050
• Length: 713
• Species: Saccharomyces cerevisiae
• Alignment Length: 686
• Identity: 306/686 - (44%)
• Similarity: 421/686 - (61%)
• Gaps: 64/686 - (9%)

  Fly     2 PAEKSIYDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQF-HWETPADQ-----DKFL 60
            ||..:.|.|        ::...::||:.::||:::||:|:...|.|| :|..|.|:     .|..
Yeast    60 PAIATHYSP--------HLDGLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTG 116

  Fly    61 KYNFNISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHP-DDYSRGLTYRKLLEE 124
            :.:|.      :..|......|.|||.:||:... ..::.|..:||:.| ..||  :||::||||
Yeast   117 RPSFQ------NNAWFLNGQLNACYNCVDRHALK-TPNKKAIIFEGDEPGQGYS--ITYKELLEE 172

  Fly   125 VCRFANVLK-DHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKA 188
            ||:.|.||. ..|:||||.|::||||:.|..|.:||.:||||:||:||||||.:||.:|:.|..:
Yeast   173 VCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDS 237

  Fly   189 KLLITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPW-TD 252
            |::||.|.:.||.|.:..|.:.|.||.:...:.|      |:.:.|...|....|...::.| |:
Yeast   238 KVVITTDESNRGGKVIETKRIVDDALRETPGVRH------VLVYRKTNNPSVAFHAPRDLDWATE 296

  Fly   253 DRDYWWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYK 317
            .:.|..:.       .|.|  :|:|||||:||||||||.||||.|:||||||.|..|.:..||..
Yeast   297 KKKYKTYY-------PCTP--VDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTH 352

  Fly   318 PGDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAI 382
            ..|:::..||:||||||||||||||..|..:::|||||.:|...|||.:||::||||||.||||:
Yeast   353 QEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTAL 417

  Fly   383 RALMKFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPL 447
            |.|.:.|:..:..|:|..|:.||||||||..|.|.||.:.|||.:..||||:||||:|.|::|||
Yeast   418 RLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPL 482

  Fly   448 P-GATPMKPGSASFPFFGVKPTLLD-ECGIEIK-GEGEGYLVFSQPWPGMMRTLYNNHERFEDTY 509
            . |.||||||||||||||:...:|| ..|.|:. ...||.|.....||...||::.||:|:.|||
Yeast   483 AGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTY 547

  Fly   510 FSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHP 574
            .:.:||||.|||||.:|.|||:||.|||||::|||||.:||||:|:.:.|.|.|||.|||.....
Yeast   548 LNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDD 612

  Fly   575 VKGECLYCFI---------TPNENEVFDQKLISDLKK----MVRERIGPFAMPDVIQNAPGLPKT 626
            :.|:.:..|:         |..::|      :.|:||    .||:.|||||.|.:|.....||||
Yeast   613 LTGQAVAAFVVLKNKSSWSTATDDE------LQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKT 671

  Fly   627 RSGKIMRRVLRKIAVNDRN-VGDTSTLADEQIVEQL 661
            ||||||||:||||...:.: :||.|||::..||..|
Yeast   672 RSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHL 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	304/681 (45%)
		ACS	30..654	CDD:213313	297/649 (46%)
ACS1	NP_009347.1	ACS	74..700	CDD:341270	299/655 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	447	1.000	Domainoid score	I62
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I151
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61013
OrthoFinder	1	1.000	-	-		FOG0001357
OrthoInspector	1	1.000	-	-		otm46606
orthoMCL	1	0.900	-	-		OOG6_100430
Panther	1	1.100	-	-	O	PTHR24095
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R19
SonicParanoid	1	1.000	-	-		X954
TreeFam	0	0.000	Not matched by this tool.
	11	10.900