Protein Alignment AcCoAS and ACS2

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_013254.1
• Gene: ACS2 / 850846
• SGDID: S000004143
• Length: 683
• Species: Saccharomyces cerevisiae
• Alignment Length: 682
• Identity: 296/682 - (43%)
• Similarity: 418/682 - (61%)
• Gaps: 47/682 - (6%)

  Fly     1 MPAEKSIYDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQF-HWETPADQDKFLKYNF 64
            :.|.:..|:..|.   ..|::..:.||:.||:|::.|.:|:.::||:: ||:.|..:
Yeast    18 LKAPQHFYNSQPG---KGYVTDMQHYQEMYQQSINEPEKFFDKMAKEYLHWDAPYTK-------- 71

  Fly    65 NISKGPIS---IKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVC 126
             :..|.::   :.|......|..||.:||:.... .|:.|..:|.:...| ::.:|:.:||.:|.
Yeast    72 -VQSGSLNNGDVAWFLNGKLNASYNCVDRHAFAN-PDKPALIYEADDESD-NKIITFGELLRKVS 133

  Fly   127 RFANVLKDHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLL 191
            :.|.|||..|::|||.|:||:|||.|..|||||.|||||:||:||||||..||.:|:.|..:|::
Yeast   134 QIAGVLKSWGVKKGDTVAIYLPMIPEAVIAMLAVARIGAIHSVVFAGFSAGSLKDRVVDANSKVV 198

  Fly   192 ITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDY 256
            ||.|...||.|.:..|.:.|..|..|:    .|.:.:|.....          .|.||....|||
Yeast   199 ITCDEGKRGGKTINTKKIVDEGLNGVD----LVSRILVFQRTG----------TEGIPMKAGRDY 249

  Fly   257 WWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDI 321
            |||||...:.....|...|||||||:||||||||.||||:|||.||||.||.|.:.|||..|.|:
Yeast   250 WWHEEAAKQRTYLPPVSCDAEDPLFLLYTSGSTGSPKGVVHTTGGYLLGAALTTRYVFDIHPEDV 314

  Fly   322 YWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRALM 386
            .:..|||||||||||.:||||..|..|:|||.||.:|...|||.:|.::|.|.||.||||:|.:.
Yeast   315 LFTAGDVGWITGHTYALYGPLTLGTASIIFESTPAYPDYGRYWRIIQRHKATHFYVAPTALRLIK 379

  Fly   387 KFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPGAT 451
            :.||..:.|::.|.|:|||||||||:|:.|.||::.:|.:.|.|.||.||||:|.|:|.||.||.
Yeast   380 RVGEAEIAKYDTSSLRVLGSVGEPISPDLWEWYHEKVGNKNCVICDTMWQTESGSHLIAPLAGAV 444

  Fly   452 PMKPGSASFPFFGVKPTLLDE-CGIEIKG-EGEGYLVFSQPWPGMMRTLYNNHERFEDTYFSKFP 514
            |.|||||:.||||:...::|. .|:|::| :.||.|....|||.|.|:::|:|:|:.|||...:|
Yeast   445 PTKPGSATVPFFGINACIIDPVTGVELEGNDVEGVLAVKSPWPSMARSVWNHHDRYMDTYLKPYP 509

  Fly   515 GYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGEC 579
            |:|.|||||.||.|||.||.|||||::|||||.:||:|:|:.::.|..|:|:|||..|..:.|:.
Yeast   510 GHYFTGDGAGRDHDGYYWIRGRVDDVVNVSGHRLSTSEIEASISNHENVSEAAVVGIPDELTGQT 574

  Fly   580 LYCFITPNE------------NEVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKTRSGKIM 632
            :..:::..:            ..:....|..:|...||..|||||.|..|.....||:|||||||
Yeast   575 VVAYVSLKDGYLQNNATEGDAEHITPDNLRRELILQVRGEIGPFASPKTIILVRDLPRTRSGKIM 639

  Fly   633 RRVLRKIAVND-RNVGDTSTLADEQIVEQLFA 663
            ||||||:|.|: ..:||.:|||:.::|..:.:
Yeast   640 RRVLRKVASNEAEQLGDLTTLANPEVVPAIIS 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	295/676 (44%)
		ACS	30..654	CDD:213313	288/642 (45%)
ACS2	NP_013254.1	ACS	38..662	CDD:341270	290/648 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	447	1.000	Domainoid score	I62
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I151
Isobase	1	0.950	-	0	Normalized mean entropy	S671
OMA	1	1.010	-	-		QHG61013
OrthoFinder	1	1.000	-	-		FOG0001357
OrthoInspector	1	1.000	-	-		otm46606
orthoMCL	1	0.900	-	-		OOG6_100430
Panther	1	1.100	-	-	O	PTHR24095
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R19
SonicParanoid	1	1.000	-	-		X954
TreeFam	0	0.000	Not matched by this tool.
	12	11.850