DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AcCoAS and ACSS1

DIOPT Version :9

Sequence 1:	NP_001014599.2	Gene:	AcCoAS / 40348	FlyBaseID:	FBgn0012034	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_115890.2	Gene:	ACSS1 / 84532	HGNCID:	16091	Length:	689	Species:	Homo sapiens

Alignment Length:	663	Identity:	304/663 - (45%)
Similarity:	415/663 - (62%)	Gaps:	43/663 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQ-FHWETPADQDKFLKYNFNISKGPISIKW 75
            ||::  |..:....|.....::...||.||..:|:. ..|:||    ....::.:.|.|.|.  |
Human    46 PAVA--AAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTP----YHTVWDCDFSTGKIG--W 102

  Fly    76 MEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDHGIRKG 140
            ..|...|:..|.||::||.. .:.:|..||.:.|....| :|||:|||..||.||.||.||:.:|
Human   103 FLGGQLNVSVNCLDQHVRKS-PESVALIWERDEPGTEVR-ITYRELLETTCRLANTLKRHGVHRG 165

  Fly   141 DRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITADGAWRGEKPLY 205
            |||:||||:......||||||||||||:::|||||.:|||.|:.|.|.|::||.:...||.:.:.
Human   166 DRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVE 230

  Fly   206 LKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTD------DRDYWWHEEMED 264
            ||.:.|.|::....:.|     ::|:|.                 ||      |.|....:||..
Human   231 LKKIVDEAVKHCPTVQH-----VLVAHR-----------------TDNKVHMGDLDVPLEQEMAK 273

  Fly   265 KEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVG 329
            ::|.|.||.|.:||.|||||||||||.|||::||.||||||||.|.|:|||::||||:.|..|:|
Human   274 EDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIG 338

  Fly   330 WITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVL 394
            |||||:|||||||.||||||:||.||.:|...|||..:::.|:.|||.||||:|.|:|:|:..|.
Human   339 WITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVK 403

  Fly   395 KHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPG--ATPMKPGS 457
            |::.|.|:.|||||||||.|||.|.::.:|..:|::|||:|||||||..|.|.|.  ...:.|..
Human   404 KYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAM 468

  Fly   458 ASFPFFGVKPTLLDECGIEIKGEG-EGYLVFSQPWPGMMRTLYNNHERFEDTYFSKFPGYYCTGD 521
            |..||||:.|.|:||.|..::|.. .|.|..||.||||.||:|.:|:||.|.||..:||||.|||
Human   469 AMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGD 533

  Fly   522 GARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITP 586
            ||.|...||..||||:||::|:|||.:.|||:|..:.:||.|.||||:..||.:|||..:.||..
Human   534 GAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVV 598

  Fly   587 NENEVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVND-RNVGDTS 650
            .::......::.:||.||..:|..:|:||.|.....||||||||:|||:||||..:: :.:|||:
Human   599 KDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTT 663

  Fly   651 TLADEQIVEQLFA 663
            ||.|..|:.::.:
Human   664 TLEDPSIIAEILS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	304/663 (46%)
AcCoAS	NP_001014599.2	ACS	30..654	CDD:213313	298/634 (47%)
ACSS1	NP_115890.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..46		304/663 (46%)
		Ac_CoA_lig_AcsA	54..676	CDD:274022	301/651 (46%)
		Coenzyme A binding. /evidence=ECO:0000250	224..227		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S671
OMA	1	1.010	-	-		QHG61013
OrthoDB	1	1.010	-	-		D148550at33208
OrthoFinder	1	1.000	-	-		FOG0001357
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100430
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R19
SonicParanoid	1	1.000	-	-		X954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.710