Protein Alignment AcCoAS and ACSS3

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 238/659 - (36%)
• Similarity: 359/659 - (54%)
• Gaps: 53/659 - (8%)

  Fly    22 SFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKWMEGASTNLCYN 86
            |..||:..:..|:.:|..||.:.|:|..|..|  ..|.|:     :|...|.:|......|:|||
Human    58 SGSEYKTHFAASVTDPERFWGKAAEQISWYKP--WTKTLE-----NKHSPSTRWFVEGMLNICYN 115

  Fly    87 LLDRNVRNGLGDQIAYYWEGNHPDDYSRG-LTYRKLLEEVCRFANVLKDHGIRKGDRVSIYMPMI 150
            .:||::.||.||:||..::.  |...::. .||:::||:|.:.|.||..|||:|||.|.||||||
Human   116 AVDRHIENGKGDKIAIIYDS--PVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMI 178

  Fly   151 LELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITAD-GAWRGEKPLYLKALCDTAL 214
            .:....|||||||||:||::|.||:...|:.|:...|.|:::||. |...|.:..|: .|.:.||
Human   179 PQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYV-PLVEEAL 242

  Fly   215 EKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEM-EDKEPACYPEWMDAED 278
             |:.:  |..:|.::.:        :|:  .|.:|....||..|.||| :.:...|.|  :.:|.
Human   243 -KIGQ--HKPDKILIYN--------RPN--MEAVPLAPGRDLDWDEEMAKAQSHDCVP--VLSEH 292

  Fly   279 PLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLA 343
            ||::|||||:||.||||:..|.||.:....:...::..:||:::|...|:||:.||:|:.||||.
Human   293 PLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLL 357

  Fly   344 NGATSVIFEGTPF-FPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVL--KHNLSGLKVLG 405
            :|.|:|::||.|. .|....|:.|:.::.|...:||||||||:.:...|..|  :::|:..|.|.
Human   358 HGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLF 422

  Fly   406 SVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPG----ATPMKPGSASFPFFGVK 466
            ..||..:.|...|.....   :..::|.:||||||..:.....|    .|| .||.|.....|..
Human   423 VAGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPITASCVGLGNSKTP-PPGQAGKSVPGYN 483

  Fly   467 PTLLDECGIEIKGEGEGYLVFSQPW-PGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARRDADGY 530
            ..:||:...::|....|.:|...|. ||....|:.|.|.|:..||.||||||.|.|....|.:||
Human   484 VMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGY 548

  Fly   531 LWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGE--CLYCFITPNENEVFD 593
            |::..||||::||:||.:|...:|..:..|..||:.|||.:..|:||.  ...|.:..:.|.. :
Human   549 LYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINAT-E 612

  Fly   594 QKLISDLKKMVRERIGPFAMPDVIQNA---PGLPKTRSGKIMRRVLRKIAVNDRNVGDTSTLADE 655
            ::::.::.|.||:.|||.|   ..:||   ..|||||||||.|..|..| ||.:....|||:.|.
Human   613 EQVLEEIVKHVRQNIGPVA---AFRNAVFVKQLPKTRSGKIPRSALSAI-VNGKPYKITSTIEDP 673

  Fly   656 QI---VEQL 661
            .|   ||::
Human   674 SIFGHVEEM 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	238/659 (36%)
		ACS	30..654	CDD:213313	231/639 (36%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	234/650 (36%)
		Coenzyme A binding. /evidence=ECO:0000250	227..230		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148550at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820