Protein Alignment AcCoAS and AACS

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_076417.2
• Gene: AACS / 65985
• HGNCID: 21298
• Length: 672
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 159/667 - (23%)
• Similarity: 297/667 - (44%)
• Gaps: 80/667 - (11%)

  Fly    22 SFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYN-----------FNISKGPISI-K 74
            :.|.|...|..|:::.::||:               :|.|::           .:.|||...: :
Human    43 ALESYDDLYHWSVESYSDFWA---------------EFWKFSGIVFSRVYDEVVDTSKGIADVPE 92

  Fly    75 WMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDHGIRK 139
            |.:|:..|...|||    |:...|::|.|......::..: :|:.:|.:||..||..::..|::|
Human    93 WFKGSRLNYAENLL----RHKENDRVALYIAREGKEEIVK-VTFEELRQEVALFAAAMRKMGVKK 152

  Fly   140 GDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITADG-AWRGEKP 203
            ||||..|:|.......||||.|.|||:.|.....|..:.:.:|....:.||:.:.:. .:.|::.
Human   153 GDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEH 217

  Fly   204 LYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVE-EEIPWTDDRDYWWHEEMEDKEP 267
            .:::     .|::|.:....::|.:|:.::.     ..:::: .:||.:...|.:......::.|
Human   218 NHME-----KLQQVVKGLPDLKKVVVIPYVS-----SRENIDLSKIPNSVFLDDFLATGTSEQAP 272

  Fly   268 ACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWIT 332
            ....|.:....|||::::||:||.||.::|:..|.|:.......:..:....||..|...|||:.
Human   273 QLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMM 337

  Fly   333 GHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVLKHN 397
            .:..|  ..||.||..|:::|:|..|..:..|.::|:..:|...|....:..|.:....||..|:
Human   338 WNWMV--SLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHS 400

  Fly   398 LSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPG---ATPMKPGSAS 459
            |..|..:.|.|.|:..:::.:.|:.|   :.||:  ......|..:|:...|   :.|:..|...
Human   401 LQMLHTILSTGSPLKAQSYEYVYRCI---KSSIL--LGSISGGTDIISCFMGHNFSLPVYKGEIQ 460

  Fly   460 FPFFGVKPTLLDECGIEIKGEGEGYLVFSQPWPGMMRTLYN--NHERFEDTYFSKFPGYYCTGDG 522
            ....|:.....:|.|..:.|| .|.||.::|.|......:|  |..::...|||||||.:..||.
Human   461 ARNLGMAVEAWNEEGKAVWGE-SGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDY 524

  Fly   523 AR-RDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITP 586
            .| ....|.:.:.||.|..||.:|....::|:.:::.....|.:|..|.:.:..:.|.:..|:..
Human   525 CRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKM 589

  Fly   587 NENEVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVNDRNVGDTST 651
            .....|...|:..::..:|..:....:|.:|....|:|.|.:||       |:
Human   590 ASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGK-------KV------------ 635

  Fly   652 LADEQIVEQLFANRPVE 668
               |..|:|:.|.:.||
Human   636 ---EVAVKQIIAGKAVE 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	157/662 (24%)
		ACS	30..654	CDD:213313	151/643 (23%)
AACS	NP_076417.2	ac_ac_CoA_syn	16..670	CDD:273507	159/667 (24%)
		AACS	40..663	CDD:213308	159/667 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810