Protein Alignment AcCoAS and Acss2

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_062785.2
• Gene: Acss2 / 60525
• MGIID: 1890410
• Length: 701
• Species: Mus musculus
• Alignment Length: 670
• Identity: 422/670 - (62%)
• Similarity: 520/670 - (77%)
• Gaps: 14/670 - (2%)

  Fly     8 YDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPIS 72
            :.|.|.:.::|::.|.:.|::.::.|::.|.|||..:||:|:|:| |....||:|||:::||.|.
Mouse    29 WSPPPEVRRSAHVPSLQRYRELHRRSVEEPREFWGNIAKEFYWKT-ACPGPFLQYNFDVTKGKIF 92

  Fly    73 IKWMEGASTNLCYNLLDRNV-RNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDHG 136
            .:||:||:||:|||:||||| ...|||::|:|||||.|.:.:: :|||:||.:||:|:|||:..|
Mouse    93 TEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTK-ITYRELLVQVCQFSNVLRKQG 156

  Fly   137 IRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITADGAWRGE 201
            |:|||||:|||||||||.:|||||||:||:|||||||||.:||.||:.|....||||.|..:|||
Mouse   157 IQKGDRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCCLLITTDAFYRGE 221

  Fly   202 KPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRV------TPCQPDHVEEEIP-----WTDDRD 255
            |.:.||.|.|.:|||..|.|..|..||||.||.|.      :|.|...|:...|     |.:..|
Mouse   222 KLVNLKELADESLEKCREKGFPVRCCIVVKHLGRAELGMNDSPSQSPPVKRPCPDVQICWNEGVD 286

  Fly   256 YWWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGD 320
            .||||.|:.....|.|||.|||||||:|||||||||||||:||..||:||.|||||.|||:.|.|
Mouse   287 LWWHELMQQAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTIGGYMLYVATTFKYVFDFHPED 351

  Fly   321 IYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRAL 385
            ::|||.|:||||||:||.|||||||||||:|||.|.:|...|.||::||||||:|||||||||.|
Mouse   352 VFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDEGRLWSIVDKYKVTKFYTAPTAIRML 416

  Fly   386 MKFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPGA 450
            ||||:.||.||:.:.|:|||:|||||||||||||::.:|.::|.|||||||||||||::||||||
Mouse   417 MKFGDDPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGSQRCPIVDTFWQTETGGHMLTPLPGA 481

  Fly   451 TPMKPGSASFPFFGVKPTLLDECGIEIKGEGEGYLVFSQPWPGMMRTLYNNHERFEDTYFSKFPG 515
            |||||||||||||||.|.:|:|.|.|::||.||||||.|||||:|||:|.||.|||.|||.||||
Mouse   482 TPMKPGSASFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPG 546

  Fly   516 YYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECL 580
            ||.||||.|||.|||.|||||:||||||||||:|||||||.|.||..|||:|||..|||||||||
Mouse   547 YYVTGDGCRRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECL 611

  Fly   581 YCFITPNENEVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVNDRN 645
            |||:|..:...|...|..:|||.:||:|||.|.||.||||||||||||||||||||||||.||.:
Mouse   612 YCFVTLCDGHTFSPTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHD 676

  Fly   646 VGDTSTLADEQIVEQLFANR 665
            :|||||:||..::..||::|
Mouse   677 LGDTSTVADPSVINHLFSHR 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	413/641 (64%)
Acss2	NP_062785.2	Interaction with TFEB. /evidence=ECO:0000250|UniProtKB:Q9NR19	1..107		32/78 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		2/7 (29%)
		ACS	45..685	CDD:341270	413/641 (64%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NR19	656..668		11/11 (100%)