Protein Alignment AcCoAS and ACSS2

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_011527207.1
• Gene: ACSS2 / 55902
• HGNCID: 15814
• Length: 737
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 423/707 - (59%)
• Similarity: 525/707 - (74%)
• Gaps: 52/707 - (7%)

  Fly     8 YDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPIS 72
            :.|.|.:|::|::.|.:.|::.::.|::.|.|||..:||:|:|:||. ...||:|||:::||.|.
Human    29 WSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPC-PGPFLRYNFDVTKGKIF 92

  Fly    73 IKWMEGASTNLCYNLLDRNV-RNGLGDQIAYYW-------------EGNHPDDYSRGLTYRKLLE 123
            |:||:||:||:|||:||||| ...|||::|:||             |||.|.:.:: :||.:||.
Human    93 IEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWSTSGNSSYRYTCREGNEPGETTQ-ITYHQLLV 156

  Fly   124 EVCRFANVLKDHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKA 188
            :||:|:|||:..||:|||||:||||||.||.:||||||||||:|||||||||.:||.||:.|...
Human   157 QVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSC 221

  Fly   189 KLLITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRV----------TP----- 238
            .||||.|..:||||.:.||.|.|.||:|.:|.|..|..||||.||.|.          :|
Human   222 SLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRS 286

  Fly   239 CQPD----------HVEEEIPWTDDRDYWWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPK 293
            | ||          .|:.:|.|....|.||||.|::....|.|||.|||||||:|||||||||||
Human   287 C-PDVQGKLKEKSKRVQPQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPK 350

  Fly   294 GVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFP 358
            ||:||..||:||.|||||.|||:...|::|||.|:||||||:||.|||||||||||:|||.|.:|
Human   351 GVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 415

  Fly   359 GNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYI 423
            ..:|.||::||||||:|||||||||.|||||:.||.||:.:.|:|||:|||||||||||||::.:
Human   416 DVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVV 480

  Fly   424 GKEQCSIVDTFWQTETGGHVITPLPGATPMKPGSASFPFFGVKPTLLDECGIEIKGEGEGYL--- 485
            |.::|.|||||||||||||::||||||||||||||:||||||.|.:|:|.|.|::||.||||
Human   481 GAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLLLR 545

  Fly   486 -------VFSQPWPGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNV 543
                   ||.|||||:|||:|.||||||.|||.||||||.||||.:||.|||.|||||:||||||
Human   546 TETSWLEVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV 610

  Fly   544 SGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITPNENEVFDQKLISDLKKMVRERI 608
            ||||:|||||||.|.||..|||:|||..||||||||||||:|..:...|..||..:|||.:||:|
Human   611 SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKI 675

  Fly   609 GPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVNDRNVGDTSTLADEQIVEQLFANR 665
            ||.|.||.||||||||||||||||||||||||.||.::||.||:||..::..||::|
Human   676 GPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHR 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	413/678 (61%)
ACSS2	XP_011527207.1	ACS	45..721	CDD:341270	413/678 (61%)