DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AcCoAS and ACSS2

DIOPT Version :9

Sequence 1:	NP_001014599.2	Gene:	AcCoAS / 40348	FlyBaseID:	FBgn0012034	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	XP_011527207.1	Gene:	ACSS2 / 55902	HGNCID:	15814	Length:	737	Species:	Homo sapiens

Alignment Length:	707	Identity:	423/707 - (59%)
Similarity:	525/707 - (74%)	Gaps:	52/707 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPIS 72
            :.|.|.:|::|::.|.:.|::.::.|::.|.|||..:||:|:|:||. ...||:|||:::||.|.
Human    29 WSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKTPC-PGPFLRYNFDVTKGKIF 92

  Fly    73 IKWMEGASTNLCYNLLDRNV-RNGLGDQIAYYW-------------EGNHPDDYSRGLTYRKLLE 123
            |:||:||:||:|||:||||| ...|||::|:||             |||.|.:.:: :||.:||.
Human    93 IEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWSTSGNSSYRYTCREGNEPGETTQ-ITYHQLLV 156

  Fly   124 EVCRFANVLKDHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKA 188
            :||:|:|||:..||:|||||:||||||.||.:||||||||||:|||||||||.:||.||:.|...
Human   157 QVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERILDSSC 221

  Fly   189 KLLITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRV----------TP----- 238
            .||||.|..:||||.:.||.|.|.||:|.:|.|..|..||||.||.|.          :|
Human   222 SLLITTDAFYRGEKLVNLKELADEALQKCQEKGFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRS 286

  Fly   239 CQPD----------HVEEEIPWTDDRDYWWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPK 293
            | ||          .|:.:|.|....|.||||.|::....|.|||.|||||||:|||||||||||
Human   287 C-PDVQGKLKEKSKRVQPQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKPK 350

  Fly   294 GVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFP 358
            ||:||..||:||.|||||.|||:...|::|||.|:||||||:||.|||||||||||:|||.|.:|
Human   351 GVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYP 415

  Fly   359 GNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYI 423
            ..:|.||::||||||:|||||||||.|||||:.||.||:.:.|:|||:|||||||||||||::.:
Human   416 DVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVV 480

  Fly   424 GKEQCSIVDTFWQTETGGHVITPLPGATPMKPGSASFPFFGVKPTLLDECGIEIKGEGEGYL--- 485
            |.::|.|||||||||||||::||||||||||||||:||||||.|.:|:|.|.|::||.||||
Human   481 GAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLLLR 545

  Fly   486 -------VFSQPWPGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNV 543
                   ||.|||||:|||:|.||||||.|||.||||||.||||.:||.|||.|||||:||||||
Human   546 TETSWLEVFKQPWPGIMRTVYGNHERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNV 610

  Fly   544 SGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITPNENEVFDQKLISDLKKMVRERI 608
            ||||:|||||||.|.||..|||:|||..||||||||||||:|..:...|..||..:|||.:||:|
Human   611 SGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKI 675

  Fly   609 GPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVNDRNVGDTSTLADEQIVEQLFANR 665
            ||.|.||.||||||||||||||||||||||||.||.::||.||:||..::..||::|
Human   676 GPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHR 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	422/705 (60%)
AcCoAS	NP_001014599.2	ACS	30..654	CDD:213313	412/672 (61%)
ACSS2	XP_011527207.1	PRK00174	31..728	CDD:234677	420/699 (60%)
ACSS2	XP_011527207.1	ACS	51..721	CDD:213313	412/672 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155538
Domainoid	1	1.000	646	1.000	Domainoid score	I160
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6469
Inparanoid	1	1.050	908	1.000	Inparanoid score	I370
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61013
OrthoDB	1	1.010	-	-		D148550at33208
OrthoFinder	1	1.000	-	-		FOG0001357
OrthoInspector	1	1.000	-	-		oto88899
orthoMCL	1	0.900	-	-		OOG6_100430
Panther	1	1.100	-	-	LDO	PTHR24095
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R19
SonicParanoid	1	1.000	-	-		X954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800