Protein Alignment AcCoAS and ACSM5

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001311301.1
• Gene: ACSM5 / 54988
• HGNCID: 26060
• Length: 582
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 167/642 - (26%)
• Similarity: 261/642 - (40%)
• Gaps: 148/642 - (23%)

  Fly     1 MPAEKSIYDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFN 65
            :|..:.|.....|||....:  ..||..|..:.||    .|||:.:..|
Human    29 LPVPQKIVATWEAISLGRQL--VPEYFNFAHDVLD----VWSRLEEAGH---------------- 71

  Fly    66 ISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFAN 130
              :.|....|..                ||.|.:|.:              ::.:|.::..:.||
Human    72 --RPPNPAFWWV----------------NGTGAEIKW--------------SFEELGKQSRKAAN 104

  Fly   131 VLKDH-GIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITA 194
            ||... |::.|||:.:.:|.:.|..:..:||.|.|.|........:...|..|:...:||.:||:
Human   105 VLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQLTEKDLKYRLQASRAKSIITS 169

  Fly   195 DG-AWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDY-- 256
            |. |.|.:.   :.|.|.           |::..::||...|     |.       |.:.|:.
Human   170 DSLAPRVDA---ISAECP-----------SLQTKLLVSDSSR-----PG-------WLNFRELLR 208

  Fly   257 ---WWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKP 318
               ..|..|..|          :.|||.:.:|||:||.||.|.|:.:.|.|....:.:.......
Human   209 EASTEHNCMRTK----------SRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTE 263

  Fly   319 GDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDR--YWSVIDKYKVTQFYTAPTA 381
            .||:|.|.|.||:.. .:.::....||:...:.|    .|..|.  ..:.:.|:.:|.....||.
Human   264 SDIFWNTTDTGWVKA-AWTLFSAWPNGSCIFVHE----LPRVDAKVILNTLSKFPITTLCCVPTI 323

  Fly   382 IRALMKFG----EGPVLKHNLSGLKVLGSVGEPINP---EAWLWYYKYIGKEQCSI--VDTFWQT 437
            .|.|::..    :...|:|.|:|       ||.:||   |.|        |.|..:  .:.:.|:
Human   324 FRLLVQEDLTRYQFQSLRHCLTG-------GEALNPDVREKW--------KHQTGVELYEGYGQS 373

  Fly   438 ETGGHVITPLPGATPMKPGS---ASFPFFGVKPTLLDECGIEIKGEGEGYLVF----SQPWPGMM 495
            ||  .||...|....:|.||   ||.|:   ...::|:.|..:....||.:..    ::|:
Human   374 ET--VVICANPKGMKIKSGSMGKASPPY---DVQIVDDEGNVLPPGEEGNVAVRIRPTRPF---- 429

  Fly   496 RTLYNNH-ERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTE 559
             ..:|.: :..|.|..|:...:|.|||.||.|.|||.|..||.||::|.|.:.:...||||.|.|
Human   430 -CFFNCYLDNPEKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINSSSYRIGPVEVESALAE 493

  Fly   560 HPRVAESAVVSRPHPVKGECLYCFI--TPNENEVFDQKLISDLKKMVRERIGPFAMP 614
            ||.|.||||||.|.|::||.:..||  ||..:....:.|..:|::.|:....|:..|
Human   494 HPAVLESAVVSSPDPIRGEVVKAFIVLTPAYSSHDPEALTRELQEHVKRVTAPYKYP 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	166/636 (26%)
		ACS	30..654	CDD:213313	159/613 (26%)
ACSM5	NP_001311301.1	Acs	49..552	CDD:223442	162/620 (26%)
		AFD_class_I	49..552	CDD:302604	162/620 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810