DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AcCoAS and Acss3

DIOPT Version :9

Sequence 1:	NP_001014599.2	Gene:	AcCoAS / 40348	FlyBaseID:	FBgn0012034	Length:	670	Species:	Drosophila melanogaster
Sequence 2:	NP_001136276.1	Gene:	Acss3 / 380660	MGIID:	2685720	Length:	682	Species:	Mus musculus

Alignment Length:	696	Identity:	240/696 - (34%)
Similarity:	369/696 - (53%)	Gaps:	72/696 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAEKSIYDPNPAISQNAYISSF-------------EEYQKFYQESLDNPAEFWSRVAKQFHWET 52
            :|...|:  ...|:::.|.::.|             .||:..:..|:.:|..||.:.|:|..|..
Mouse    21 LPGSPSV--RGAAVTRRALVAGFGGRGCRALTTGSGGEYKTHFAASVADPERFWGKAAEQISWYK 83

  Fly    53 PADQDKFLKYNFNISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLT 117
            |  ..|.|:     |:.|.|..|......|:|||.:||::.||.||:||..:: :...|....::
Mouse    84 P--WTKTLE-----SRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYD-SPVTDTKATIS 140

  Fly   118 YRKLLEEVCRFANVLKDHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAER 182
            |:::||:|.:.|.||...|::|||.|.||||||.:....|||||||||:||::|.||:...|:.|
Mouse   141 YKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYTMLACARIGAIHSLIFGGFASKELSTR 205

  Fly   183 MFDCKAKLLITAD-GAWRGEKPLYLKALCDTALEKVEEMG-HSVEKCIVVSHLKRVTPCQPDHVE 245
            :...|.|:::||. |...|.|..|:     ..||:...:| |..::.::.|        :|:  .
Mouse   206 IDHAKPKVVVTASFGIEPGRKVEYI-----PLLEEALRIGQHRPDRVLIYS--------RPN--M 255

  Fly   246 EEIPWTDDRDYWWHEEM-EDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATT 309
            |::|....||..|.||| :.:...|.|  :.:|.||::|||||:||.||||:..|.||.:....|
Mouse   256 EKVPLMSGRDLDWEEEMAKAQSHDCVP--VLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWT 318

  Fly   310 FKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPF-FPGNDRYWSVIDKYKVT 373
            ...::..|||:::|...|:||:.||:|:.||||.:|.|:|::||.|. .|....|:.|:.::.|.
Mouse   319 MSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVA 383

  Fly   374 QFYTAPTAIRALMKFGEGPVL--KHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQ 436
            ..:||||||||:.:...|..|  :::|:..|.|...||..:.|...|..|..   :..::|.:||
Mouse   384 ALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVF---RVPVLDHWWQ 445

  Fly   437 TETGGHVITPLPG----ATPMKPGSASFPFFGVKPTLLDECGIEIKGEGEGYLVFSQPW-PGMMR 496
            ||||..:.....|    .|| .||.|.....|....:||:...::|....|.:|...|. ||...
Mouse   446 TETGSPITASCIGLGNSKTP-PPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFS 509

  Fly   497 TLYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHP 561
            .|:.|.|.|:..||.||||||.|.|....|.:|||::..||||::||:||.:|...:|..:..|.
Mouse   510 GLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHG 574

  Fly   562 RVAESAVVSRPHPVKGE--CLYCFITPNENEVFDQKLISDLKKMVRERIGPFAMPDVIQNA---P 621
            .||:.|||.:..|:||.  ...|.:..:.| ..:::::.::.|.||:.|||.|   ..:||   .
Mouse   575 TVADCAVVGKEDPLKGHVPLALCVLKKDVN-ASEEQVLEEIVKHVRQSIGPVA---AFRNAVFVK 635

  Fly   622 GLPKTRSGKIMRRVLRKIAVNDRNVGDTSTLAD-------EQIVEQ 660
            .|||||||||.|..|..: ||.:....|.|:.|       |::::|
Mouse   636 QLPKTRSGKIPRSTLSAL-VNGKPYKVTPTIEDPSIFGHIEEVLKQ 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	238/690 (34%)
AcCoAS	NP_001014599.2	ACS	30..654	CDD:213313	230/639 (36%)
Acss3	NP_001136276.1	PrpE	57..674	CDD:341271	232/650 (36%)
Acss3	NP_001136276.1	Coenzyme A binding. /evidence=ECO:0000250	222..225		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148550at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820