Protein Alignment AcCoAS and Acsm5

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001014184.3
• Gene: Acsm5 / 361637
• RGDID: 1309578
• Length: 578
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 172/677 - (25%)
• Similarity: 272/677 - (40%)
• Gaps: 180/677 - (26%)

  Fly    10 PNPAISQNAYISSFE----------EYQKFYQESLDNPAEFWSRVAKQFH-------WETPADQD 57
            |.|.|.:  .::::|          ||..|..:.||    .||::.|..|       |
  Rat    27 PPPPIPE--VVATWEAISLGKRPVPEYFNFAHDVLD----VWSQLEKTGHRPPNPAFW------- 78

  Fly    58 KFLKYNFNISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLL 122
                             |:.|:.|.:                   .|            |:.:|.
  Rat    79 -----------------WVNGSGTEV-------------------KW------------TFEELG 95

  Fly   123 EEVCRFANVLKDH-GIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDC 186
            ::..:.||:|:.. |::.|||:.:.:|.:.|..:.::||.|.|.|.....:..:...|..|:...
  Rat    96 KQSRKAANILEGACGLKPGDRLMLVLPRLPEWWLTIVACMRTGVVMIPGISQLTQKDLKYRLQAA 160

  Fly   187 KAKLLITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWT 251
            :.|.:||:|            ||. ..::.:.....|::..::||...|     |.       |.
  Rat   161 RVKSIITSD------------ALA-PHVDAISADCPSLQSRLLVSDTSR-----PG-------WI 200

  Fly   252 DDRDYWWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDY 316
            :.|:..   .:...|..|..  ..:.|.:.:.:|||:||.||.|.|:...|.|....:.:.:...
  Rat   201 NFRELL---RVASPEHNCLR--TRSGDSMAIYFTSGTTGTPKMVEHSQCSYGLGFVASGRRLMAL 260

  Fly   317 KPGDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGND--RYWSVIDKYKVTQFYTAP 379
            ...||:|.|.|.||:.. .:.::...||||...:.|    .|..|  ...:.:.::.:|.....|
  Rat   261 TESDIFWNTTDTGWVKA-AWTLFSAWANGACVFVHE----LPQVDAQTILNTLCRFPITTICCVP 320

  Fly   380 TAIRALM-------KFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQT 437
            |..|.|:       ||   ..|:|.|:|       ||.:|                |.|...|:.
  Rat   321 TLFRLLVQEDLTRYKF---QCLRHCLAG-------GEALN----------------SDVRDKWKN 359

  Fly   438 ETG-------GHVITPL-----PGATPMKPGS---ASFPFFGVKPTLLDECGIEIKGEGEGYLVF 487
            :||       |...|.|     .|:| :|.||   ||.|:   ...::||.|..:....||.:..
  Rat   360 QTGLEIHEGYGQSETVLICGNFRGST-IKSGSMGKASPPY---DVQIVDEEGNVLPPGKEGNIAI 420

  Fly   488 ----SQPWPGMMRTLYNNH-ERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHL 547
                ::|:     .|:|.: :..|.|..|:...:|.|||.|..|.|||.|..||.||::|.|.:.
  Rat   421 RIKPTRPF-----CLFNCYLDNPEKTAASEQGDFYITGDRAHMDEDGYFWFVGRNDDVINSSSYR 480

  Fly   548 MSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFI--TPNENEVFDQKLISDLKKMVRERIGP 610
            :...||||.|.|||.|.||||||.|.|::||.:..||  :|.......:.|..:|::.|:....|
  Rat   481 IGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLSPAYVSHDPEALTRELQEHVKTVTAP 545

  Fly   611 FAMPDVIQNAPGLPKTRSGKIMRRVLR 637
            :..|..:.....||||.||||:|..||
  Rat   546 YKYPRKVAFISELPKTVSGKILRSKLR 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	169/663 (25%)
Acsm5	NP_001014184.3	Adenylate forming domain, Class I superfamily	48..576	CDD:473059	168/654 (26%)