Protein Alignment AcCoAS and ACSM6

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_997204.2
• Gene: ACSM6 / 142827
• HGNCID: 31665
• Length: 480
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 121/521 - (23%)
• Similarity: 196/521 - (37%)
• Gaps: 129/521 - (24%)

  Fly    63 NFNISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWE---GNHPDDYSRGLTYRKLLEE 124
            |||.:|..:. :|.:          |:   ::||.......|:   ....|.:|    :.::.:.
Human    48 NFNFAKDVLD-QWSQ----------LE---KDGLRGPYPALWKVSAKGEEDKWS----FERMTQL 94

  Fly   125 VCRFANVLKDH-GIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKA 188
            ..:.|::|.|. .:..|||:.|.:|...|.....|||.|:|    |.|...||...|:::   :.
Human    95 SKKAASILSDTCALSHGDRLMIILPPTPEAYWICLACVRLG----ITFVPGSPQLTAKKI---RY 152

  Fly   189 KLLITADGAWRGEKPLYLKALCDTALEKVEEMGHS-VEKC------IVVSHLKRVTPCQPDHVEE 246
            :|.::             ||.|..|.|.:..:.:| |..|      ::||
Human   153 QLRMS-------------KAQCIVANEAMAPVVNSAVSDCPTLKTKLLVS--------------- 189

  Fly   247 EIPWTDDRDYWWHEEMEDKEPACYPEWMD------------------AEDPLFMLYTSGSTGKPK 293
                             ||.   |..|:|                  ::||:.:.:|.|:||.||
Human   190 -----------------DKS---YDGWLDFKKLIQVAPPKQTYMRTKSQDPMAIFFTKGTTGAPK 234

  Fly   294 GVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFP 358
            .|.::..|..:..:...:...|.:|.|:.|..||....:.....|.|....||...:.....|.|
Human   235 MVEYSQYGLGMGFSQASRRWMDLQPTDVLWSLGDAFGGSLSLSAVLGTWFQGACVFLCHMPTFCP 299

  Fly   359 GNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVLKHNLSGLKVLGSVGEPINP---EAWLWYY 420
              :...:|:.::.:|.....|...:.|::  ......:....||...:.|.||:|   |.|
Human   300 --ETVLNVLSRFPITTLSANPEMYQELLQ--HKCFTSYRFKSLKQCVAAGGPISPGVIEDW---- 356

  Fly   421 KYIGKEQCSIVDTFWQTETGGHVITPLPGATPMKPGSASFPFFGVKPTLLDECGIEIKGEGEGYL 485
            |.|.|  ..|.:.:.|||||  ::........:||.|...|.......::||....:....||.:
Human   357 KRITK--LDIYEGYGQTETG--LLCATSKTIKLKPSSLGKPLPPYIVQIVDENSNLLPPGEEGNI 417

  Fly   486 V----FSQPWPGMMRTLYNNHERFEDTYFSKFPGY--YCTGDGARRDADGYLWITGRVDDMLNVS 544
            .    .:||     .:||..|....:.|.|. .|:  |.|||....|.|||.|.:|||||:.|..
Human   418 AIRIKLNQP-----ASLYCPHMVSWEEYASA-RGHMLYLTGDRGIMDEDGYFWWSGRVDDVANAL 476

  Fly   545 G 545
            |
Human   477 G 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	121/521 (23%)
		ACS	30..654	CDD:213313	121/521 (23%)
ACSM6	NP_997204.2	AFD_class_I	45..480	CDD:302604	121/521 (23%)
		AMP-binding	76..472	CDD:278902	109/472 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810