Protein Alignment AcCoAS and ACSM2A

DIOPT Version :9

• Sequence 1: NP_001014599.2
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001295101.1
• Gene: ACSM2A / 123876
• HGNCID: 32017
• Length: 577
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 165/669 - (24%)
• Similarity: 264/669 - (39%)
• Gaps: 170/669 - (25%)

  Fly    15 SQNAYISSFE--EYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKWME 77
            |:..||:|.:  ..|..:||.   ||:|........||   ||.:|..|.    ...| ::.|:.
Human    20 SRTLYINSRQLVSLQWGHQEV---PAKFNFASDVLDHW---ADMEKAGKR----LPSP-ALWWVN 73

  Fly    78 GASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDH-GIRKGD 141
            |....|.:|                               :|:|.|...:.||||... |:::||
Human    74 GKGKELMWN-------------------------------FRELSENSQQAANVLSGACGLQRGD 107

  Fly   142 RVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFD-------CKAKLLITADGAWR 199
            ||::.:|.:.|..:.:|.|.|.|.:       |.|.::..:..|       .|||.::..|
Human   108 RVAVVLPRVPEWWLVILGCIRAGLI-------FMPGTIQMKSTDILYRLQMSKAKAIVAGD---- 161

  Fly   200 GEKPLYLKALCDTALEKVEEMGHSVEKC--IVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEM 262
                           |.::|:.....:|  :.:..|.....|               |.|.:.:.
Human   162 ---------------EVIQEVDTVASECPSLRIKLLVSEKSC---------------DGWLNFKK 196

  Fly   263 EDKEPACYPEWMD--AEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFD-----YKPGD 320
            ...|.:.....::  :::...:.:|||::|.||...|:      |::...|...|     .:..|
Human   197 LLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS------YSSLGLKAKMDAGWTGLQASD 255

  Fly   321 IYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDK----YKVTQFYTAPTA 381
            |.|...|.|||......:..|.|.||.:.:.....|.|      .||.|    |.:.....||..
Human   256 IMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDP------LVILKTLSSYPIKSMMGAPIV 314

  Fly   382 IRALMKFGEGPVLKHNLSGLKV-----LGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGG 441
            .|.|        |:.:||..|.     ..:|||.:.||....:....|.:   |.:::.|||||
Human   315 YRML--------LQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLD---IRESYGQTETG- 367

  Fly   442 HVITPLPGAT-PMKPGSASFPFFGVKPTLLDECGIEIKG-------EGE-GYLVFSQPWPGMMRT 497
              :|.:...| .:|||     :.|...:..|...|:.||       ||: |..|......|:...
Human   368 --LTCMVSKTMKIKPG-----YMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSG 425

  Fly   498 LYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPR 562
            ..:|.::   |..:....::..||...:|.|||....||.:|::|.||:.:..:|||:.|.|||.
Human   426 YVDNPDK---TAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPA 487

  Fly   563 VAESAVVSRPHPVKGECLYCFIT---------PNENEVFDQKLISDLKKMVRERIGPFAMPDVIQ 618
            |.|:||:|.|.||:||.:..|:.         |       ::|..:|::.|:....|:..|..|:
Human   488 VVETAVISSPDPVRGEVVKAFVVLASQFLSHDP-------EQLTKELQQHVKSVTAPYKYPRKIE 545

  Fly   619 NAPGLPKTRSGKIMRRVLR 637
            ....||||.:|||.|..||
Human   546 FVLNLPKTVTGKIQRAKLR 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_001014599.2	PRK00174	7..665	CDD:234677	165/669 (25%)
		ACS	30..654	CDD:213313	160/652 (25%)
ACSM2A	NP_001295101.1	AFD_class_I	40..568	CDD:388389	158/649 (24%)
		Coenzyme A binding. /evidence=ECO:0000269|PubMed:19345228	469..471		1/1 (100%)
		Coenzyme A binding. /evidence=ECO:0000269|PubMed:19345228	540..542		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0365
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810