Protein Alignment AcCoAS and ACSM2A

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001295101.1
• Gene: ACSM2A / 123876
• HGNCID: 32017
• Length: 577
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 165/669 - (24%)
• Similarity: 264/669 - (39%)
• Gaps: 170/669 - (25%)

  Fly    15 SQNAYISSFE--EYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKWME 77
            |:..||:|.:  ..|..:||.   ||:|........||   ||.:|..|.    ...| ::.|:.
Human    20 SRTLYINSRQLVSLQWGHQEV---PAKFNFASDVLDHW---ADMEKAGKR----LPSP-ALWWVN 73

  Fly    78 GASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDH-GIRKGD 141
            |....|.:|                               :|:|.|...:.||||... |:::||
Human    74 GKGKELMWN-------------------------------FRELSENSQQAANVLSGACGLQRGD 107

  Fly   142 RVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFD-------CKAKLLITADGAWR 199
            ||::.:|.:.|..:.:|.|.|.|.:       |.|.::..:..|       .|||.::..|
Human   108 RVAVVLPRVPEWWLVILGCIRAGLI-------FMPGTIQMKSTDILYRLQMSKAKAIVAGD---- 161

  Fly   200 GEKPLYLKALCDTALEKVEEMGHSVEKC--IVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEM 262
                           |.::|:.....:|  :.:..|.....|               |.|.:.:.
Human   162 ---------------EVIQEVDTVASECPSLRIKLLVSEKSC---------------DGWLNFKK 196

  Fly   263 EDKEPACYPEWMD--AEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFD-----YKPGD 320
            ...|.:.....::  :::...:.:|||::|.||...|:      |::...|...|     .:..|
Human   197 LLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS------YSSLGLKAKMDAGWTGLQASD 255

  Fly   321 IYWCTGDVGWITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDK----YKVTQFYTAPTA 381
            |.|...|.|||......:..|.|.||.:.:.....|.|      .||.|    |.:.....||..
Human   256 IMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDP------LVILKTLSSYPIKSMMGAPIV 314

  Fly   382 IRALMKFGEGPVLKHNLSGLKV-----LGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGG 441
            .|.|        |:.:||..|.     ..:|||.:.||....:....|.:   |.:::.|||||
Human   315 YRML--------LQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLD---IRESYGQTETG- 367

  Fly   442 HVITPLPGAT-PMKPGSASFPFFGVKPTLLDECGIEIKG-------EGE-GYLVFSQPWPGMMRT 497
              :|.:...| .:|||     :.|...:..|...|:.||       ||: |..|......|:...
Human   368 --LTCMVSKTMKIKPG-----YMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSG 425

  Fly   498 LYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPR 562
            ..:|.::   |..:....::..||...:|.|||....||.:|::|.||:.:..:|||:.|.|||.
Human   426 YVDNPDK---TAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPA 487

  Fly   563 VAESAVVSRPHPVKGECLYCFIT---------PNENEVFDQKLISDLKKMVRERIGPFAMPDVIQ 618
            |.|:||:|.|.||:||.:..|:.         |       ::|..:|::.|:....|:..|..|:
Human   488 VVETAVISSPDPVRGEVVKAFVVLASQFLSHDP-------EQLTKELQQHVKSVTAPYKYPRKIE 545

  Fly   619 NAPGLPKTRSGKIMRRVLR 637
            ....||||.:|||.|..||
Human   546 FVLNLPKTVTGKIQRAKLR 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	161/660 (24%)
ACSM2A	NP_001295101.1	Adenylate forming domain, Class I superfamily	40..568	CDD:473059	158/649 (24%)