Protein Alignment AcCoAS and Acsm1

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_001407267.1
• Gene: Acsm1 / 117147
• MGIID: 2152200
• Length: 601
• Species: Mus musculus
• Alignment Length: 558
• Identity: 135/558 - (24%)
• Similarity: 211/558 - (37%)
• Gaps: 144/558 - (25%)

  Fly    35 DNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKWMEGASTNLCYNLLDRNVRNGLGDQ 99
            |:|.||........:|....::.|         :||....|..                ||.||:
Mouse    40 DSPEEFNFASDVLDYWAQMEEEGK---------RGPSPAFWWV----------------NGQGDE 79

  Fly   100 IAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKD-HGIRKGDRVSIYMPMILELPIAMLACARI 163
            |.:              ::|||.:..||.|||.:. .|:::||.:::.:|.:.|..:..:.|.|.
Mouse    80 IKW--------------SFRKLRDLTCRTANVFEQICGLQQGDHLALILPRVPEWWLVTVGCMRT 130

  Fly   164 GAVHSIVFAGFSPDSLAERMFDCKAKLLITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKC- 227
            |.:       |.|.:...:..|...::.|:.           .||:..|| ..|.|:.....:|
Mouse   131 GII-------FMPGTTQLKAKDILYRIQISR-----------AKAIVTTA-SLVPEVESVASECP 176

  Fly   228 -----IVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEMEDKEP--ACYPEWMDAEDPLFMLYT 285
                 :|||          ||..|  .|.|     :...::...|  .|....|  :||:.:.:|
Mouse   177 DLKTKLVVS----------DHSHE--GWLD-----FCSLIKSASPDHTCIKSKM--KDPMAIFFT 222

  Fly   286 SGSTGKPKGVLHTTA-GYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLANGATSV 349
            ||:||.||...|... .:..|..:..|:: ..|..||.||..|.|||......:..|..:|.|..
Mouse   223 SGTTGYPKMAKHNQGLAFRSYIPSCRKLL-KLKTSDILWCMSDPGWILATVGCLIEPWTSGCTVF 286

  Fly   350 IFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRAL-------MKFGEGPVLKHNLSGLKVLGSV 407
            |.....|.|  .....|:.||.:||...||...|.:       ::|   |.|:|..:|
Mouse   287 IHHLPQFDP--KVIVEVLFKYPITQCLAAPGVYRMVLQQKTSNLRF---PTLEHCTTG------- 339

  Fly   408 GEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPGAT----PMKPGS---ASFPFFGV 465
            ||.:.||.   |.::..:...||.:.:.|:|||      :..||    .:|.||   |..||
Mouse   340 GESLLPEE---YEQWKQRTGLSIHEVYGQSETG------ISSATLREMKIKRGSIGKAILPF--- 392

  Fly   466 KPTLLDECGIEIKGEGEGYLVF----SQPWPGMMRTLYNNH------ERFEDTYFSKFPGYYCTG 520
            ...::||.|..:....|||:..    ::|. |:......:|      ||......|   |..|.|
Mouse   393 DLQIIDEKGNILPPNTEGYIGIRIKPTRPL-GLFMEYEVSHRACRGGERLGGAPSS---GRVCGG 453

  Fly   521 D----GARRDADGYLWITGRVDDMLNVSGHLMSTAEVE 554
            :    |:||..:|......||....:.:.:..:||..|
Mouse   454 EQPGQGSRRGGEGVYCPQPRVPVTRSGTAYQRATASCE 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	135/558 (24%)
Acsm1	NP_001407267.1	Adenylate forming domain, Class I superfamily	42..>429	CDD:473059	118/489 (24%)