DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9391 and IMPA1

DIOPT Version :9

Sequence 1:	NP_649294.1	Gene:	CG9391 / 40346	FlyBaseID:	FBgn0037063	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001138350.1	Gene:	IMPA1 / 3612	HGNCID:	6050	Length:	336	Species:	Homo sapiens

Alignment Length:	273	Identity:	128/273 - (46%)
Similarity:	183/273 - (67%)	Gaps:	5/273 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EKCLEVASNLVSEAGRLIARNNEQRQDFVCKSNDIDLVTQTDKDVEQLLMDGIRRHFPEHKFIGE 72
            ::|::.|..|..:||.::....:...:.:.||:.:||||.||:.||::|:..|:..:|.|.||||
Human    65 QECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGE 129

  Fly    73 EESSGAEGVKK-LTDEPTWIIDPVDGTMNFVHAFPHSCISVGLKVNKVTELGLVYNPILEQRFTA 136
            |  |.|.|.|. |||.|||||||:|||.||||.||...:|:|..|||..|.|:||:.:..:.:||
Human   130 E--SVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTA 192

  Fly   137 RRGHGAFYNGRRIHVSGQKELGKALVTSEFGTTRDEAKMKVVHENFEKM-AKKAHGLRVLGSAAL 200
            |:|.|||.||:::.||.|:::.|:|:.:|.|::|....:::|..|.||: ....||:|.:|:||:
Human   193 RKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAV 257

  Fly   201 NMSMVALGAADANYEFGIHAWDVCAGDLIVREAGGVVIDPAGGEFDIMSRRVLAAATPELAQEIS 265
            ||.:||.|.|||.||.|||.|||....:||.|||||::|..||.||:|||||:||....||:.|:
Human   258 NMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIA 322

  Fly   266 KVLTQFNPLPRDD 278
            |.: |..||.|||
Human   323 KEI-QVIPLQRDD 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9391	NP_649294.1	IMPase	10..255	CDD:238817	116/246 (47%)
IMPA1	NP_001138350.1	IMPase	67..313	CDD:238817	117/247 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2217
eggNOG	1	0.900	-	-		E1_COG0483
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4043
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3238
Isobase	1	0.950	-	0	Normalized mean entropy	S1410
OMA	1	1.010	-	-		QHG54074
OrthoDB	1	1.010	-	-		D406919at33208
OrthoFinder	1	1.000	-	-		FOG0000745
OrthoInspector	1	1.000	-	-		mtm8602
orthoMCL	1	0.900	-	-		OOG6_100401
Panther	1	1.100	-	-	LDO	PTHR20854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2586
SonicParanoid	1	1.000	-	-		X706
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820