DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and NR1D2

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_005117.3	Gene:	NR1D2 / 9975	HGNCID:	7963	Length:	579	Species:	Homo sapiens

Alignment Length:	675	Identity:	204/675 - (30%)
Similarity:	301/675 - (44%)	Gaps:	160/675 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 NGGGALYTISSVHQFGPASNHNTSSSSPSSSAAHSSPDSGCSSASSSGSSRSCGSSSASSSSSAV 277
            |.||.:..|||          ::|:|||:|          |.|..|..|.:|..||..||.:|:.
Human     4 NAGGVIAYISS----------SSSASSPAS----------CHSEGSENSFQSSSSSVPSSPNSSN 48

  Fly   278 SSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHPQQQQSFGLADS 342
            |.|  :|...|..:.|....      |..::....:.|::
Human    49 SDT--NGNPKNGDLANIEGI------LKNDRIDCSMKTSK------------------------- 80

  Fly   343 SSSNGSSNNNNGVS--SKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEY-RCLRDGK 404
            ||:.|.:.:::||:  |...:.||||||.|||:||||.:|||||||||||||:.|:| :||::..
Human    81 SSAPGMTKSHSGVTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNEN 145

  Fly   405 CLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDSTSS 469
            |.::|:||||||.||||||||.|||||:||:||:|||.::.......||     ....::...|.
Human   146 CSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSA-----MKTMMNSQFSG 205

  Fly   470 TLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQP--------HVSGVRVK----TPSTPQT 522
            .|....|.:..:|..|..|:|.:.:|||:|.:.....|        .|.|:..:    |....|.
Human   206 HLQNDTLVEHHEQTALPAQEQLRPKPQLEQENIKSSSPPSSDFAKEEVIGMVTRAHKDTFMYNQE 270

  Fly   523 PQMCSIASSPSELGGCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGH------QQLVGGSMV 581
            .|..|..|...:.|.....|....|.|:...||     |:|       .|      ||.:.|...
Human   271 QQENSAESMQPQRGERIPKNMEQYNLNHDHCGN-----GLS-------SHFPCSESQQHLNGQFK 323

  Fly   582 GMAGMG-TDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCS--YTEELTRELMRRPVTVPQ 643
            |...|. .:.|.:                     |::..|.:|.|  ||:.:...       ||.
Human   324 GRNIMHYPNGHAI---------------------CIANGHCMNFSNAYTQRVCDR-------VPI 360

  Fly   644 NGIASTVAESLEFQKIWL----------------------------WQQFSARVTPGVQRIVEFA 680
            :|.:..     |.:..:|                            |::||...||.|:.:||||
Human   361 DGFSQN-----ENKNSYLCNTGGRMHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFA 420

  Fly   681 KRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLIN--EATLTLDDGAYLTRQQLEILYDSDFVNA 743
            ||:|||.|.:|.||:.|:|.|.|||.:...|.|.:  |.|:|...|...:...|..:...|.:|:
Human   421 KRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNS 485

  Fly   744 LLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQILRSRAGSPQA 808
            :..|:..|||..|||.|:.||:|:||:::||:|:.....:...:|.:..|||..|:::.   |..
Human   486 MFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH---PNE 547

  Fly   809 LQLMPALEAKIPELRSLGAKHFSHL 833
            ..:...|..|:|:||||...|...|
Human   548 ASIFTKLLLKLPDLRSLNNMHSEEL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	58/80 (73%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	66/205 (32%)
NR1D2	NP_005117.3	Modulating	1..99		34/147 (23%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q60674	1..60		25/77 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..61		21/69 (30%)
		NR_DBD_REV_ERB	98..186	CDD:143540	58/87 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..250		7/27 (26%)
		NR_LBD_REV_ERB	389..577	CDD:132738	65/187 (35%)
		Interaction with ZNHIT1. /evidence=ECO:0000269\|PubMed:17892483	397..579		65/179 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4846
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3060
Isobase	1	0.950	-	0	Normalized mean entropy	S6355
OMA	1	1.010	-	-		QHG47784
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820