DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eip78C and NR1D1

DIOPT Version :9

Sequence 1:NP_001246862.1 Gene:Eip78C / 40345 FlyBaseID:FBgn0004865 Length:862 Species:Drosophila melanogaster
Sequence 2:NP_068370.1 Gene:NR1D1 / 9572 HGNCID:7962 Length:614 Species:Homo sapiens


Alignment Length:702 Identity:209/702 - (29%)
Similarity:294/702 - (41%) Gaps:200/702 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 SNHNTSS-----SSPSSSAAHSSPDS---------------GCSS---ASSSGS-----SRSCGS 267
            ||:||..     .|..||.:.:||:|               ||.:   .|.:||     :||.||
Human     6 SNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGS 70

  Fly   268 SSASSSSSAVSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHPQ 332
            ...|.|.....|:.||..||::|..|.:                  |...||             
Human    71 IPPSLSDDGSPSSSSSSSSSSSSFYNGS------------------PPGSLQ------------- 104

  Fly   333 QQQSFGLADSSSSNGSSNNNNGVSSKSFV-PCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIE 396
                ..:.|||..:.|.:.:|.......| .||||||.|||:||||.:|||||||||||||:.|:
Human   105 ----VAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQ 165

  Fly   397 Y-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSA--AAGAP 458
            | |||::..|.::|:||||||.||||||||.|||||:||:||:|||.::...|...||  .|...
Human   166 YKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQ 230

  Fly   459 ASLNVDDSTSSTLHP---------------------SHLQQQ-----------QQQHLLQQQQQQ 491
            .|......||.|.||                     |...||           ..:.::.|..:.
Human   231 LSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARA 295

  Fly   492 QHQPQLQQHHQLQQQP------HVSGVRVKTPSTPQTPQMCSIASSPSELGGCNSANNNNNNNNN 550
            ..:.....|.:|...|      |.||   ..|:|  ||...       |..||..|.|:||    
Human   296 HREIFTYAHDKLGSSPGNFNANHASG---SPPAT--TPHRW-------ENQGCPPAPNDNN---- 344

  Fly   551 SSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMAGM------GTDAHQVGMCHDGLAGTANELTV 609
                           .:....|.:.:.|.....:..      |...|.   ||.     :|    
Human   345 ---------------TLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHS---CHQ-----SN---- 382

  Fly   610 YDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIAS------------------TVAESLEF 656
                   |..||| |. |........:.|...|:.|.:.                  ||.|    
Human   383 -------SNGHRL-CP-THVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQE---- 434

  Fly   657 QKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTL 721
                :|:.||...||.|:.:|||||.:|||.|.:|.||:.|:|.|.|||.:...|.|.|....|:
Human   435 ----IWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTV 495

  Fly   722 DDGAYLTR-----QQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPK 781
               .:|:|     |:|..:...|.::|:.:|:..||:..|::.|:|||:|:||:::||:|:....
Human   496 ---MFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSA 557

  Fly   782 VIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            .:.:.:|.:..|||..:|::|   |........|..|:|:||:|...|...|
Human   558 SVEQLQETLLRALRALVLKNR---PLETSRFTKLLLKLPDLRTLNNMHSEKL 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eip78CNP_001246862.1 NR_DBD_DmE78_like 363..443 CDD:143539 59/80 (74%)
NR_LBD_DmE78_like 659..854 CDD:132739 63/180 (35%)
NR1D1NP_068370.1 Modulating 1..128 36/156 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..119 35/147 (24%)
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q3UV55 1..70 17/63 (27%)
Crucial for activation of GJA1. /evidence=ECO:0000250 49..284 97/269 (36%)
NR_DBD_REV_ERB 127..215 CDD:143540 60/87 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 233..285 8/51 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 311..345 15/64 (23%)
NR_LBD 418..611 CDD:325017 66/203 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4846
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 265 1.000 Inparanoid score I3060
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.860

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