DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and RORA

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_599022.1	Gene:	RORA / 6095	HGNCID:	10258	Length:	556	Species:	Homo sapiens

Alignment Length:	562	Identity:	150/562 - (26%)
Similarity:	244/562 - (43%)	Gaps:	127/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 QQQLQHPQQQQSFGLADSSSSNGSSNNNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRR 389
            :|..:.|..|:.    |.....|..|     :....:|||:||||:||.||||.:||||||||||
Human    77 RQNGKPPYSQKE----DKEVQTGYMN-----AQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRR 132

  Fly   390 SIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAA 454
            |.|....|.|.|...||:.|.:|||||:||.:|||:.|||||:|::||:.|:.|:
Human   133 SQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRD---------- 187

  Fly   455 AGAPASLNVDDSTSSTLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPST 519
                                .|..:.|:|.:||||:..           ||||        ..:.
Human   188 --------------------SLYAEVQKHRMQQQQRDH-----------QQQP--------GEAE 213

  Fly   520 PQTPQMCSIASSPSELGGCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMA 584
            |.||.....|:..:||         :::.:|...|:...||.....|                 :
Human   214 PLTPTYNISANGLTEL---------HDDLSNYIDGHTPEGSKADSAV-----------------S 252

  Fly   585 GMGTDAH----QVGMCHDGL-------------------------AGTANELTVYDVIMCVSQAH 620
            ....|..    |.|:..:|:                         :.|.:...:..:...:|::|
Human   253 SFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSH 317

  Fly   621 RLNCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPG 685
            ...|.|..|..:::      ..|..:...:......|:..:||..:.::|..:|.:||||||:.|
Human   318 LETCQYLREELQQI------TWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDG 376

  Fly   686 FCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTL-DDGAYLTRQQLEILYDSDFVNALLNFAN 749
            |.:..|:||::|:|.|..||....:.|..:....|: .||.|.:....:.|...||::.:..|..
Human   377 FMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGK 441

  Fly   750 TLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPA 814
            :|.:..|::.||.||||.||:::||:.|.|...|.:.::.:..||:..:.::....    .::..
Human   442 SLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHRED----GILTK 502

  Fly   815 LEAKIPELRSLGAKHFSHLDWLRMNW---TKLRLPPLFAEIF 853
            |..|:..||:|..:|...|...:..:   .:|..|||:.|:|
Human   503 LICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELF 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	49/79 (62%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	59/199 (30%)
RORA	NP_599022.1	NR_DBD_ROR	99..193	CDD:143526	52/123 (42%)
RORA	NP_599022.1	NR_LBD_ROR_like	305..544	CDD:132737	65/248 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010