DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip78C and roraa

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	XP_017209577.1	Gene:	roraa / 564951	ZFINID:	ZDB-GENE-060306-2	Length:	519	Species:	Danio rerio

Alignment Length:	560	Identity:	154/560 - (27%)
Similarity:	257/560 - (45%)	Gaps:	91/560 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 PLPTTQLQQQQQHQQQLQHPQQQQSFGLADSSSSNG-SSNNNNGVSSKSFVPCKVCGDKASGYHY 375
            |:..|.:..:...:.:.|.|.::||.    ||::.| |.......|....:|||:||||:||.||
Zfish    21 PVRETPVNLETLRKAEHQAPVRRQSC----SSTNRGISVTKKTHTSQIEIIPCKICGDKSSGIHY 81

  Fly   376 GVTSCEGCKGFFRRSIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPK 440
            ||.:|||||||||||.|....|.|.|...||:.|.:|||||:||.:|||:.|||||:|::||:.|
Zfish    82 GVITCEGCKGFFRRSQQSNAAYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSK 146

  Fly   441 RSRELNGAAASSAAAGAPASLNVDDSTSSTLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQ 505
            :.|:                              .|..:.|:|.|||||:..           ||
Zfish   147 KQRD------------------------------SLYAEVQKHRLQQQQRDH-----------QQ 170

  Fly   506 QPHVSGVRVKTPSTPQTPQMCSIASSPSELGGCNSANNNNNNNNNSSSGNASGG----SGVSVGV 566
            ||        ..:.|.||......:..:||         :::.:...:|:...|    ||||...
Zfish   171 QP--------GEAEPLTPTYGLSTNGLTEL---------HDDLSGYMNGHTPDGTKPDSGVSSFY 218

  Fly   567 VVVGGHQQLVGGSMVGM---------AGMGTDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRL 622
            :.:.......|..:.|:         .|.|...: ....:...:.|.:...:..:...:|::|..
Zfish   219 LDIQPSPDQSGLDINGIKPEPICDFTPGSGFFPY-CSFTNGETSPTVSMAELEHLAQNISKSHME 282

  Fly   623 NCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFC 687
            .|.|..|..:::..:...  |..:.:..::..|.    :||..:.::|..:|.:||||||:.||.
Zfish   283 TCQYLREELQQMTWQAFL--QEEVENYQSKPREV----MWQLCAIKITEAIQYVVEFAKRIDGFM 341

  Fly   688 DFTQDDQLILIKLGFFEVWLTHVARLINEATLTL-DDGAYLTRQQLEILYDSDFVNALLNFANTL 751
            :..|:||::|:|.|..||....:.|..:....|: .||.|......:.|...|.::::..|...|
Zfish   342 ELCQNDQIVLLKAGSLEVVFVRMCRAFDPQNNTVYFDGKYAGPDVFKSLGCDDLISSVFEFGKNL 406

  Fly   752 NAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALE 816
            .:..||:.||.||||.||:::||:.|.|...:.:.::.:..||:..:.::....    .::..|.
Zfish   407 CSMHLSEDEIALFSAFVLMSADRSWLQEKVKVEKLQQKIQLALQHVLQKNHRED----GILTKLI 467

  Fly   817 AKIPELRSLGAKHFSHLDWLRMNW---TKLRLPPLFAEIF 853
            .|:..||:|.::|...|...:..:   .:...|||:.|:|
Zfish   468 CKVSTLRALCSRHTEKLTAFKAIYPDIVRAHFPPLYKELF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	49/79 (62%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	57/199 (29%)
roraa	XP_017209577.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010