Protein Alignment Eip78C and nr1d4a

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: XP_021325494.1
• Gene: nr1d4a / 563150
• ZFINID: ZDB-GENE-080403-5
• Length: 572
• Species: Danio rerio
• Alignment Length: 656
• Identity: 187/656 - (28%)
• Similarity: 289/656 - (44%)
• Gaps: 154/656 - (23%)

  Fly   222 SSVHQFGPASNHNTSSSSPSSSAAHSSPDSGCSSASSSGSSRSCGSSSASSSSSAVSSTISSGRS 286
            ||.....|:|.:.|  .||||.:..|||:.  .:.:..|:.:..|::.:.:|...|   ......
Zfish    20 SSPSPGSPSSGYQT--QSPSSHSQPSSPEE--VTFTEIGAFKQQGNAGSPNSPKLV---FQFPEI 77

  Fly   287 SNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHP-QQQQSFGLADSSSSNGSSN 350
            .|||...|...|.|                             || ..::..|...:.:..|.
Zfish    78 YNNSTAGPNPHSYS-----------------------------HPIAGKRPCGFTGTFTKTGG-- 111

  Fly   351 NNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYR-CLRDGKCLVIRLNRNR 414
                    ..:.||||||.|||:||||.:|||||||||||||:.|.|: |:::..||::|:||||
Zfish   112 --------MVLLCKVCGDIASGFHYGVHACEGCKGFFRRSIQQNINYKMCVKNENCLIMRMNRNR 168

  Fly   415 CQYCRFKKCLSAGMSRDSVRYGRVPKRSRE------------LNGAA------------------ 449
            ||:||||||||.|||||:||:||:|||.::            ||.::
Zfish   169 CQHCRFKKCLSVGMSRDAVRFGRIPKREKQRLLDEMQSYMNSLNESSMGMETSPQHEPPPSPIEN 233

  Fly   450 ASSAAAGAPASLNVDDSTSSTLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPH---VSG 511
            .|..|.||.:....|..|::   ..||.::...:.:.:....|:.|....::     ||   ::|
Zfish   234 QSKEAIGALSRAYQDIFTNT---QDHLNKRAGNNNISRSSSYQNSPSQDSNY-----PHANPLAG 290

  Fly   512 VRVKTPSTPQTPQMCSIASSPSELGGC--NSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGHQQ 574
            ....|..:...|..|.:::|.|:   |  :..:||..:...|.|.|                |.|
Zfish   291 YHTTTHESFSGPVRCPVSTSESK---CPVSLVDNNRYSYAPSFSQN----------------HSQ 336

  Fly   575 LVGGSMVGMAGMGTDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCSY-----TEELTREL 634
                |.|......|.||               .:.|......|.|   :|.:     ::.|...|
Zfish   337 ----SSVNQPSQPTQAH---------------YSSYTASQSQSPA---SCPFKLAAGSKVLACPL 379

  Fly   635 MRRPVTVPQNGIASTVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIK 699
            ...||:.|  |::|        |::  |:.||...||.|:.:|||||.:|||.:..|.||::|:|
Zfish   380 NACPVSAP--GVSS--------QQV--WESFSQCFTPAVREVVEFAKGIPGFQELCQHDQVMLLK 432

  Fly   700 LGFFEVWLTHVARLIN--EATLTLDDGAYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIG 762
            .|.|:|.:.....|.|  |.::|..:|.......|..|.....::|:..|::.|::.||...|:.
Zfish   433 AGTFQVLMVRFCSLFNHKERSVTFLNGQTYPLGTLRGLGMGSLLDAMFEFSSKLSSLGLESDEMA 497

  Fly   763 LFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGA 827
            ||.|:||:::|.:|:|:...:.:.:|.:..|||..|.|..   |....|...|..::|:||:|..
Zfish   498 LFMAVVLVSADCSGISDMLAVEQLQEGLIRALRTLINRRH---PDDNSLFSKLLLRLPDLRTLNN 559

  Fly   828 KHFSHL 833
            .|...|
Zfish   560 LHSDKL 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	58/80 (73%)
		NR_LBD_DmE78_like	659..854	CDD:132739	58/177 (33%)
nr1d4a	XP_021325494.1	NR_DBD_REV_ERB	111..199	CDD:143540	58/97 (60%)
		NR_LBD	382..570	CDD:472173	64/199 (32%)