Protein Alignment Eip78C and nr1d1

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: NP_991292.2
• Gene: nr1d1 / 494487
• ZFINID: ZDB-GENE-050105-1
• Length: 637
• Species: Danio rerio
• Alignment Length: 708
• Identity: 205/708 - (28%)
• Similarity: 312/708 - (44%)
• Gaps: 164/708 - (23%)

  Fly   207 LNCT----LSNGGGALYTISSV----HQFGPASNHNTSSSS---------------PSSSAAHSS 248
            ||.|    .:|.||.:..|.|.    ::..|.|.::.:|:|               ||.:.:|.|
Zfish     6 LNMTTAVDTNNTGGVISYIGSCGGSPNRTSPVSMYSENSNSSMQSLTQPCFGSSFPPSPNGSHDS 70

  Fly   249 PD--SGCSSASSSGSSRSCGSSSASSSSSAVSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQ 311
            ..  :..||:|||||... |:||.|..|       ..||....|..|  :.:.|||.|.|
Zfish    71 SRMYTSSSSSSSSGSGED-GNSSCSGGS-------PRGRDDGGSARN--SPNKSVATLTK----- 120

  Fly   312 PLPTTQLQQQQQHQQQLQHPQQQQSFGLADSSSSNGSSNNNNGVSSKSFVPCKVCGDKASGYHYG 376
                                                    .||:    .:.||||||.|||:|||
Zfish   121 ----------------------------------------LNGM----VLLCKVCGDVASGFHYG 141

  Fly   377 VTSCEGCKGFFRRSIQKQIEY-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPK 440
            |.:|||||||||||||:.|:| :||::..|.::|:||||||.||||||||.|||||:||:||:||
Zfish   142 VHACEGCKGFFRRSIQQNIQYKKCLKNETCTIMRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPK 206

  Fly   441 RSR-----ELNGA---------------AASSAAAGAPASLNVDDSTSSTLHPS---HLQQQQQQ 482
            |.:     |:..|               |:.::....|:|.:..:::||:..|.   .:..|.|.
Zfish   207 REKQRMLAEMQNAMNNMVNNQLQNEFQLASITSNTPCPSSSSPSNTSSSSSSPCPGLTVGPQPQP 271

  Fly   483 HLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMC-------SIAS---------- 530
            ..:...|............||.|.|         |....||..|       :||:
Zfish   272 PAVPVAQSPSSPAPTSPTVQLAQSP---------PPLTSTPPPCTSPGVDKTIAAITRAHRETFI 327

  Fly   531 -SPSELGG----CNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGH------QQLVGGSMVGMA 584
             :..:||.    .||..:|.:||...:..:.:|.:.:......|..|      ||  ..|:...|
Zfish   328 YAHDKLGSPLLPHNSELDNRSNNRCMAGYHLNGHNTIYHHDNNVAHHCNNFEVQQ--DNSLHFQA 390

  Fly   585 GMGTDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRE-LMRRPVTV-PQNGIA 647
            ....:.||....:......:|..:::......|.:...||.:.:.  :| |:..|:.: |.:...
Zfish   391 SQTPEKHQQHNNNSQRPPNSNFYSIHHGQEMNSASQGQNCPWKKH--KEILLACPMNMHPYSDPN 453

  Fly   648 STVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVAR 712
            .|..|        :|:.||...||.|:.:|||||.:|||...:|:||:.|:|.|.|||.:...:.
Zfish   454 KTPQE--------IWEDFSLSFTPAVREVVEFAKHIPGFSTLSQNDQVTLLKAGTFEVLMVRFSS 510

  Fly   713 LIN--EATLTLDDGAYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRA 775
            |.|  |.|:|...||..:.:.|:.:...|.:..:.:|:..||:..||..|:|||:|:||:::||:
Zfish   511 LFNVKEKTVTFISGATYSLEALKSMGMGDLLGTMFDFSEKLNSLELSAEELGLFTAVVLVSADRS 575

  Fly   776 GLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            |:.....:...:|.:..|||..:.:|   :|........|..|:|:||:|...|...|
Zfish   576 GIENVNSVEMLQESLIRALRTLVSKS---APTDASRFTKLLLKLPDLRTLNNMHSEKL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	58/80 (73%)
		NR_LBD_DmE78_like	659..854	CDD:132739	61/177 (34%)
nr1d1	NP_991292.2	NR_DBD_REV_ERB	123..211	CDD:143540	59/91 (65%)
		NR_LBD_REV_ERB	448..635	CDD:132738	64/194 (33%)