DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip78C and nr1d1

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_991292.2	Gene:	nr1d1 / 494487	ZFINID:	ZDB-GENE-050105-1	Length:	637	Species:	Danio rerio

Alignment Length:	708	Identity:	205/708 - (28%)
Similarity:	312/708 - (44%)	Gaps:	164/708 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 LNCT----LSNGGGALYTISSV----HQFGPASNHNTSSSS---------------PSSSAAHSS 248
            ||.|    .:|.||.:..|.|.    ::..|.|.::.:|:|               ||.:.:|.|
Zfish     6 LNMTTAVDTNNTGGVISYIGSCGGSPNRTSPVSMYSENSNSSMQSLTQPCFGSSFPPSPNGSHDS 70

  Fly   249 PD--SGCSSASSSGSSRSCGSSSASSSSSAVSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQ 311
            ..  :..||:|||||... |:||.|..|       ..||....|..|  :.:.|||.|.|
Zfish    71 SRMYTSSSSSSSSGSGED-GNSSCSGGS-------PRGRDDGGSARN--SPNKSVATLTK----- 120

  Fly   312 PLPTTQLQQQQQHQQQLQHPQQQQSFGLADSSSSNGSSNNNNGVSSKSFVPCKVCGDKASGYHYG 376
                                                    .||:    .:.||||||.|||:|||
Zfish   121 ----------------------------------------LNGM----VLLCKVCGDVASGFHYG 141

  Fly   377 VTSCEGCKGFFRRSIQKQIEY-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPK 440
            |.:|||||||||||||:.|:| :||::..|.::|:||||||.||||||||.|||||:||:||:||
Zfish   142 VHACEGCKGFFRRSIQQNIQYKKCLKNETCTIMRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPK 206

  Fly   441 RSR-----ELNGA---------------AASSAAAGAPASLNVDDSTSSTLHPS---HLQQQQQQ 482
            |.:     |:..|               |:.::....|:|.:..:::||:..|.   .:..|.|.
Zfish   207 REKQRMLAEMQNAMNNMVNNQLQNEFQLASITSNTPCPSSSSPSNTSSSSSSPCPGLTVGPQPQP 271

  Fly   483 HLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMC-------SIAS---------- 530
            ..:...|............||.|.|         |....||..|       :||:
Zfish   272 PAVPVAQSPSSPAPTSPTVQLAQSP---------PPLTSTPPPCTSPGVDKTIAAITRAHRETFI 327

  Fly   531 -SPSELGG----CNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGH------QQLVGGSMVGMA 584
             :..:||.    .||..:|.:||...:..:.:|.:.:......|..|      ||  ..|:...|
Zfish   328 YAHDKLGSPLLPHNSELDNRSNNRCMAGYHLNGHNTIYHHDNNVAHHCNNFEVQQ--DNSLHFQA 390

  Fly   585 GMGTDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRE-LMRRPVTV-PQNGIA 647
            ....:.||....:......:|..:::......|.:...||.:.:.  :| |:..|:.: |.:...
Zfish   391 SQTPEKHQQHNNNSQRPPNSNFYSIHHGQEMNSASQGQNCPWKKH--KEILLACPMNMHPYSDPN 453

  Fly   648 STVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVAR 712
            .|..|        :|:.||...||.|:.:|||||.:|||...:|:||:.|:|.|.|||.:...:.
Zfish   454 KTPQE--------IWEDFSLSFTPAVREVVEFAKHIPGFSTLSQNDQVTLLKAGTFEVLMVRFSS 510

  Fly   713 LIN--EATLTLDDGAYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRA 775
            |.|  |.|:|...||..:.:.|:.:...|.:..:.:|:..||:..||..|:|||:|:||:::||:
Zfish   511 LFNVKEKTVTFISGATYSLEALKSMGMGDLLGTMFDFSEKLNSLELSAEELGLFTAVVLVSADRS 575

  Fly   776 GLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            |:.....:...:|.:..|||..:.:|   :|........|..|:|:||:|...|...|
Zfish   576 GIENVNSVEMLQESLIRALRTLVSKS---APTDASRFTKLLLKLPDLRTLNNMHSEKL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	58/80 (73%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	61/177 (34%)
nr1d1	NP_991292.2	NR_DBD_REV_ERB	123..211	CDD:143540	59/91 (65%)
nr1d1	NP_991292.2	NR_LBD_REV_ERB	448..635	CDD:132738	64/194 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4846
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3402
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.860