DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and Rorc

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	XP_006232988.2	Gene:	Rorc / 368158	RGDID:	1595785	Length:	508	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	158/537 - (29%)
Similarity:	259/537 - (48%)	Gaps:	99/537 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 VPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCLS 425
            :|||:||||:||.||||.:|||||||||||.|..:.|.|.|...|.:.|.:|||||:||.:|||:
  Rat    29 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLA 93

  Fly   426 AGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDSTSSTLHPSHLQQQQQQHLLQQQQQ 490
            .|||||:|::||:.|:.|:                         :|| :.:|:|.||   |||::
  Rat    94 LGMSRDAVKFGRMSKKQRD-------------------------SLH-AEVQKQLQQ---QQQRE 129

  Fly   491 QQHQPQLQQHHQLQQQPHVSGV---RVKTPSTPQTPQMCSIASSPSELGGCNSANNNNNN----- 547
            |..:......|......:..||   ::...::|..|:  :.|..|..|....|....:|.
  Rat   130 QVAKTPPAGSHGADTLTYTLGVPDGQLPLGASPDLPE--ASACPPGLLRASGSGPPYSNTLAKTE 192

  Fly   548 --------NNNSSSGNASGGSGV--SVGVVVVGGHQQLVGGSMVGMAGMGTDAH-QVGMCHDGLA 601
                    ..:...|.|.|...:  :.|.:.:|..     |..:|....|:|:| ....|....|
  Rat   193 VQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRR-----GLQLGEPEQGSDSHCSPSFCSAPEA 252

  Fly   602 GTANELTVYDVIMCVSQAHRLNCSY-TEELTRE----LMRRPVTVPQNGIASTVAESLEFQKIW- 660
            ..|:...:..::..|.:::|..|.. .|:|.|:    ..|..||            |.:.:.:|
  Rat   253 PYASLTDIEYLVQNVCKSYRETCQLRLEDLLRQRTNLFSREEVT------------SYQRKSMWE 305

  Fly   661 LWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTL-DDG 724
            :|::.:..:|..:|.:||||||:.||.:..|:||:||:|.|..||.|..:.|..|....|: .:|
  Rat   306 MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLKAGAMEVVLVRMCRAYNANNHTVFFEG 370

  Fly   725 AYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRAREL 789
            .|...:....|..|:.::::.:|::.|:|...|:.||.|::|:||:.::|.||.|.:.:...:..
  Rat   371 KYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYN 435

  Fly   790 VAEALRVQILRS-RAGSPQALQLMPALEAKIP---ELRSLGAKH------FSHLDWLRMNWTKLR 844
            :..|....:.:: |.|          |.||:|   :||||.::|      |.||..:.:   :..
  Rat   436 LELAFHHHLCKTHRQG----------LLAKLPPKGKLRSLCSQHVEKLQDFQHLHPIVV---QAA 487

  Fly   845 LPPLFAEIF--DIPKAD 859
            .|||:.|:|  ||..::
  Rat   488 FPPLYKELFSTDIESSE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	48/79 (61%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	63/208 (30%)
Rorc	XP_006232988.2	NR_DBD_ROR	24..118	CDD:143526	52/114 (46%)
Rorc	XP_006232988.2	NR_LBD_ROR_like	258..496	CDD:132737	72/262 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010