Protein Alignment Eip78C and Nr1d2

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: NP_001412823.1
• Gene: Nr1d2 / 353187
• MGIID: 2449205
• Length: 586
• Species: Mus musculus
• Alignment Length: 688
• Identity: 205/688 - (29%)
• Similarity: 299/688 - (43%)
• Gaps: 179/688 - (26%)

  Fly   213 NGGGALYTISSVHQFGPASNHNTSSSSPSSSAAHSSPDSGCSSASSSGSSRSCGSSSASSSSSAV 277
            |.||.:..|||          ::|:|||:|          |.|..|..|.:       |||||..
Mouse     4 NAGGVIAYISS----------SSSASSPAS----------CHSEGSENSFQ-------SSSSSVP 41

  Fly   278 SSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHPQQQQSFGLADS 342
            ||..||...:|.:..| |..||....|..::...|:.|                         ..
Mouse    42 SSPNSSNCDANGNPKN-ADISSIDGVLKSDRTDCPVKT-------------------------GK 80

  Fly   343 SSSNGSSNNNNGVSSKSFVP------------CKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQI 395
            :|:.|.:.:::|:::..|:.            ||||||.|||:||||.:|||||||||||||:.|
Mouse    81 TSAPGMTKSHSGMTTFYFLSPYALEFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNI 145

  Fly   396 EY-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPA 459
            :| :||::..|.::|:||||||.||||||||.|||||:||:||:|||.::.......||.
Mouse   146 QYKKCLKNENCSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM----- 205

  Fly   460 SLNVDDSTSSTLHPSHLQ-----QQQQQHLLQQQQQQQHQPQLQQHHQLQQQP------HVSGVR 513
                 .:..:|....|||     :|..|..|..|:|.:.:.||:|.: ::..|      .|.|:.
Mouse   206 -----KTMMNTQFSGHLQNDTLAEQHDQSALPAQEQLRPKSQLEQEN-IKNTPSDFAKEEVIGMV 264

  Fly   514 VKTPSTP----QTPQMCSIASSPSELGGCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGH-- 572
            .:.....    |..:..|..|.|.:.|.....|....|.|....     |||:.       .|
Mouse   265 TRAHKDTFLYNQEHRENSSESMPPQRGERIPRNMEQYNLNQDHR-----GSGIH-------NHFP 317

  Fly   573 ----QQLVGGSMVGMAGMG-TDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRLN--------- 623
                ||.:.|...|...|. .:.|.|                     |::..|.:|
Mouse   318 CSERQQHLSGQYKGRNIMHYPNGHAV---------------------CIANGHCMNFSSAYTQRV 361

  Fly   624 --------CSYTE-------------ELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFSA 667
                    ||.||             .|...:.:.|...||.....            :|::||.
Mouse   362 CDRIPVGGCSQTENRNSYLCNTGGRMHLVCPMSKSPYVDPQKSGHE------------IWEEFSM 414

  Fly   668 RVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLIN--EATLTLDDGAYLTRQ 730
            ..||.|:.:||||||:|||.|.:|.||:.|:|.|.|||.:...|.|.:  |.|:|...|...:..
Mouse   415 SFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 479

  Fly   731 QLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALR 795
            .|..:...|.::::..|:..|||..|||.|:.||:|:||:::||:|:.....:...:|.:..|||
Mouse   480 DLHSMGAGDLLSSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALR 544

  Fly   796 VQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            ..|:::.   |....:...|..|:|:||||...|...|
Mouse   545 TLIMKNH---PNEASIFTKLLLKLPDLRSLNNMHSEEL 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	58/80 (73%)
		NR_LBD_DmE78_like	659..854	CDD:132739	64/177 (36%)
Nr1d2	NP_001412823.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..256		9/31 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..292		4/18 (22%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	404..586		64/191 (34%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:29533925	1..60		27/83 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..90		30/129 (23%)