DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and Rorb

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_001257887.1	Gene:	Rorb / 309288	RGDID:	1306778	Length:	459	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	160/520 - (30%)
Similarity:	243/520 - (46%)	Gaps:	102/520 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 VPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCLS 425
            :|||:||||:||.||||.:|||||||||||.|....|.|.|...||:.|.||||||:||.:|||:
  Rat     8 IPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLA 72

  Fly   426 AGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDSTSSTLHPSHLQQQQQQHLLQQQQQ 490
            .|||||:|::||:.|:.|:               ||             :.:.|:.|..||:|:|
  Rat    73 LGMSRDAVKFGRMSKKQRD---------------SL-------------YAEVQKHQQRLQEQRQ 109

  Fly   491 QQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMCSIASSPSELGGCNSANNNNNNNNNSSSGN 555
            ||                 ||         :...:..:.||        |.:|..:|.|..:.|.
  Rat   110 QQ-----------------SG---------EAEALARVYSS--------SISNGLSNLNTETGGT 140

  Fly   556 ASGGSGV----SVGVVVVGGHQQLVGGSMVGMAGMGT-------DAHQV-----------GMCHD 598
            .:.|..:    |.|...:...|.....|.:.|.|:..       |...|           |....
  Rat   141 YANGHVIDLPKSEGYYNIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAP 205

  Fly   599 GLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQ 663
            |:..:..:....::|    ::|...|.||.|...:|..:..|..:  |.:..::|.|.    |||
  Rat   206 GITMSEIDRIAQNII----KSHLETCQYTMEELHQLAWQTHTYEE--IKAYQSKSREA----LWQ 260

  Fly   664 QFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLT-LDDGAYL 727
            |.:.::|..:|.:||||||:.||.:..|:||::|:|.|..||.|..:.|..|....| |.:|.|.
  Rat   261 QCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYG 325

  Fly   728 TRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAE 792
            ..|..:.|...|.||...:||..|.:..|::.||.|||:.||::.|||.|.||:.:.:.:|.:..
  Rat   326 GMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLLEPRKVQKLQEKIYF 390

  Fly   793 ALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHLDWLRMNWTKL---RLPPLFAEIFD 854
            ||:..|.::....    :.:..|.||||.:.::...|...|...:.:...:   ..|||:.|:|:
  Rat   391 ALQHVIQKNHLDD----ETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFN 451

Fly 855 854
Rat 452 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	50/79 (63%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	66/198 (33%)
Rorb	NP_001257887.1	NR_DBD_ROR	3..97	CDD:143526	54/116 (47%)
Rorb	NP_001257887.1	NR_LBD_ROR_like	210..450	CDD:132737	77/253 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010