DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip78C and raraa

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	XP_005156109.1	Gene:	raraa / 30680	ZFINID:	ZDB-GENE-980526-284	Length:	447	Species:	Danio rerio

Alignment Length:	540	Identity:	128/540 - (23%)
Similarity:	201/540 - (37%)	Gaps:	182/540 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 PQQQQSFGLADSSSSNGSSNNNNGVSSKSFV--------------PCKVCGDKASGYHYGVTSCE 381
            |....:..|:..|:.:.::......||:..|              ||.||.||:|||||||::||
Zfish    32 PPSLPTLPLSGYSTPSPATIETQSTSSEEIVPSPPSPPPPPRIYKPCFVCQDKSSGYHYGVSACE 96

  Fly   382 GCKGFFRRSIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELN 446
            ||||||||||||.:.|.|.|:..|::.::.||||||||.:|||..|||::|||..|
Zfish    97 GCKGFFRRSIQKNMVYTCHREKNCIINKVTRNRCQYCRLQKCLEVGMSKESVRNDR--------- 152

  Fly   447 GAAASSAAAGAPASLNVDDSTSSTLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSG 511
                                                   .::::::.:|:..:::.|........
Zfish   153 ---------------------------------------NKKKKEEKKPECTENYTLSPDTEQMI 178

  Fly   512 VRVKTPSTPQTPQMCSIASSPSELGGCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGHQQLV 576
            .||:.......|.:|       :||...::|::.
Zfish   179 DRVRKAHQETFPSLC-------QLGKYTTSNSSE------------------------------- 205

  Fly   577 GGSMVGMAGMGTDAHQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTV 641
                                                                       ||
Zfish   206 -----------------------------------------------------------RR---- 207

  Fly   642 PQNGIASTVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVW 706
                    ||..::     ||.:||...|..:.:.|||||::|||...|..||:.|:|....::.
Zfish   208 --------VALDVD-----LWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 259

  Fly   707 LTHVARLI--NEATLTLDDGAYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVL 769
            :..:....  .:.|:|..||..|.|.|:.........:.:..|||.|....:.|.|.||.||:.|
Zfish   260 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICL 324

  Fly   770 LASDRAGLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHLD 834
            |..||..|.:...:...:|.:.|||::.:...|...|   .:.|.:..||.:|||:.||....:.
Zfish   325 LCGDRQDLEQADKVDVLQEPLLEALKIYVRNRRPHKP---HMFPKMLMKITDLRSISAKGAERVI 386

  Fly   835 WLRMNWTKLRLPPLFAEIFD 854
            .|:|. ....:|||..|:.:
Zfish   387 TLKME-IPGSMPPLIQEMLE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	48/79 (61%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	60/196 (31%)
raraa	XP_005156109.1	NR_DBD_RAR	72..156	CDD:143522	49/131 (37%)
raraa	XP_005156109.1	NR_LBD_RAR	177..406	CDD:132735	71/347 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2459
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940