Protein Alignment Eip78C and vdra

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: NP_570994.1
• Gene: vdra / 30076
• ZFINID: ZDB-GENE-000210-31
• Length: 453
• Species: Danio rerio
• Alignment Length: 526
• Identity: 114/526 - (21%)
• Similarity: 206/526 - (39%)
• Gaps: 124/526 - (23%)

  Fly   339 LADSSSSNGSSNNNNGVSSKSFVP-CKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRD 402
            :|.|:|:.|...     ..::..| |.||||||:|:|:...:|||||||||||::::..:.|..:
Zfish    36 MAVSTSATGQDQ-----FDRNAPPICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFN 95

  Fly   403 GKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDST 467
            |.|.:.:.||..||.||.|:|:..||.::.:......:|.::|........||
Zfish    96 GNCTITKDNRRHCQACRLKRCIDIGMMKEFILTDEEVQRKKDLIMKRKEEEAA------------ 148

  Fly   468 SSTLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMCSIASSP 532
                      ::.::..|..:|.|.....::.||:.....:...||.:.|          :...|
Zfish   149 ----------REARKPRLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPP----------VREGP 193

  Fly   533 SELGGCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMAGMGTDAHQVGMCH 597
            .......:|:.::.::.:|.|.|.|..|
Zfish   194 VTRSASRAASLHSLSDASSDSFNHSPES------------------------------------- 221

  Fly   598 DGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLW 662
                 ...:|...:::|....:...:.|..::.:|..|     :|.  :|..|:.|
Zfish   222 -----VDTKLNFSNLLMMYQDSGSPDSSEEDQQSRLSM-----LPH--LADLVSYS--------- 265

  Fly   663 QQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTLDDGA-- 725
                      :|:::.|||.:|||.|.|.:||:.|:|....|:.:     |.:..:.:|:|.:
Zfish   266 ----------IQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIM-----LRSNQSFSLEDMSWS 315

  Fly   726 -------YLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVI 783
                   |......:..:..:.:..|:.|...|....|.:.|..|..|:.||:.||.|:.:...|
Zfish   316 CGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRI 380

  Fly   784 GRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHLDWLRMN-WTKLRLPP 847
            ...::.:.:.|:..|   |...|....|...:..|:.:||||..:|......|... ...::|.|
Zfish   381 EALQDRLCDVLQAYI---RIQHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTP 442

  Fly   848 LFAEIF 853
            |..|:|
Zfish   443 LVLEVF 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	34/79 (43%)
		NR_LBD_DmE78_like	659..854	CDD:132739	48/205 (23%)
vdra	NP_570994.1	NR_DBD_VDR	48..154	CDD:143513	38/127 (30%)
		Hinge. /evidence=ECO:0000250|UniProtKB:P11473	129..158		5/50 (10%)
		NR_LBD_VDR	156..452	CDD:132731	72/379 (19%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250|UniProtKB:P13053	274..292		9/17 (53%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473	442..450		4/7 (57%)