DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and Nr1d2

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_671743.2	Gene:	Nr1d2 / 259241	RGDID:	628828	Length:	578	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	204/680 - (30%)
Similarity:	297/680 - (43%)	Gaps:	171/680 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 NGGGALYTISSVHQFGPASNHNTSSSSPSSSAAHSSPDSGCSSASSSGSSRSCGSSSASSSSSAV 277
            |.||.:..|||          ::|:|||:|          |.|..|..|.:|..||..||.:|
  Rat     4 NAGGVIAYISS----------SSSASSPAS----------CHSEGSENSFQSSSSSVPSSPNS-- 46

  Fly   278 SSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHPQQQQSFGLADS 342
            |:..::|...|..|      ||....|..::...|:.|                         ..
  Rat    47 SNCDANGNPKNTDV------SSIDGVLKSDRTDCPVKT-------------------------GK 80

  Fly   343 SSSNGSSNNNNGVS--SKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEY-RCLRDGK 404
            ..:.|.:.:::|::  |...:.||||||.|||:||||.:|||||||||||||:.|:| :||::..
  Rat    81 PGAPGMTKSHSGMTKFSGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNEN 145

  Fly   405 CLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDSTSS 469
            |.::|:||||||.||||||||.|||||:||:||:|||.::.......||.          .:..|
  Rat   146 CSIMRMNRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAM----------KTMMS 200

  Fly   470 TLHPSHLQ-----QQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMCSIA 529
            |....|||     :..:|.:...|:|.:.:|||:|.:            :|  |||
  Rat   201 TQFGGHLQSDTLAEPHEQSVPPAQEQLRPKPQLEQEN------------IK--STP--------- 242

  Fly   530 SSPSE------LGGCNSAN------NNNNNNNNSSSGNASGGSGVSVGVVVVG-GHQQLVGGSMV 581
             .||:      :|....|:      |..:..|:|.|.....|..:...|.... .|....||...
  Rat   243 -PPSDFAKEEVIGMVTRAHKDTFLYNQEHRENSSESMPPHRGERIPRNVEQYNLNHDHRGGGLHS 306

  Fly   582 GMAGMGTDAHQVG------MCHDGLAGTANELTVYDVIMCVSQAHRLN----------------- 623
            ......:..|..|      |.|     ..|..||     |:|..|.:|
  Rat   307 HFPCSESQQHLSGQYKGRNMMH-----YPNGHTV-----CISNGHCVNFSSAYPQRVCDRIPVGG 361

  Fly   624 CSYTE-------------ELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFSARVTPGVQR 675
            ||.||             .|...:.:.|...||.....            :|::||...||.|:.
  Rat   362 CSQTESRNSYLCSTGGRMHLVCPMSKSPYVDPQKSGHE------------IWEEFSMSFTPAVKE 414

  Fly   676 IVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLIN--EATLTLDDGAYLTRQQLEILYDS 738
            :||||||:|||.|.:|.||:.|:|.|.|||.:...|.|.:  |.|:|...|...:...|..:...
  Rat   415 VVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAG 479

  Fly   739 DFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQILRSRA 803
            |.::::..|:..||...|||.|:.||:|:||:::||:|:.....:...:|.:..|||..|:::.
  Rat   480 DLLSSMFEFSEKLNGLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH- 543

  Fly   804 GSPQALQLMPALEAKIPELRSLGAKHFSHL 833
              |....:...|..|:|:||||...|...|
  Rat   544 --PNEASIFTKLLLKLPDLRSLNNMHSEEL 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	58/80 (73%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	63/177 (36%)
Nr1d2	NP_671743.2	Modulating	1..99		33/147 (22%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q60674	1..60		24/77 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..89		27/128 (21%)
		NR_DBD_REV_ERB	98..186	CDD:143540	58/87 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..247		13/56 (23%)
		NR_LBD_REV_ERB	388..576	CDD:132738	66/199 (33%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	396..578		63/191 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3239
OMA	1	1.010	-	-		QHG47784
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970