DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and Nr1d1

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_001106893.2	Gene:	Nr1d1 / 252917	RGDID:	628827	Length:	614	Species:	Rattus norvegicus

Alignment Length:	694	Identity:	212/694 - (30%)
Similarity:	312/694 - (44%)	Gaps:	167/694 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 SNGGGALYTISSVHQFGPASNHNTSSSSP------SSSAAHSSPDSGCSS---ASSSGS-----S 262
            :|.||.:..|.|       |..:.|.:||      ||:.:..|...||.:   .|.:||     :
  Rat     8 NNTGGVITYIGS-------SGSSPSRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPA 65

  Fly   263 RSCGSSSASSSSSAVSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQ 327
            ||.|:...|.|..:..|:.||..||::|..|.:                  |...||...:...:
  Rat    66 RSFGTVPPSLSDDSSPSSASSSSSSSSSFYNGS------------------PPGSLQVAMEDSSR 112

  Fly   328 LQHPQQQQSFGLADSSSSNGSSN--NNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRS 390
            :              |.|.|:||  ..||:    .:.||||||.|||:||||.:|||||||||||
  Rat   113 V--------------SPSKGTSNITKLNGM----VLLCKVCGDVASGFHYGVHACEGCKGFFRRS 159

  Fly   391 IQKQIEY-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRE---------- 444
            ||:.|:| |||::..|.::|:||||||.||||||||.|||||:||:||:|||.::
  Rat   160 IQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQNAM 224

  Fly   445 --LNGAAAS-----SAAAGAPASLNVDDSTSSTLHPSHL----QQQQQ-------------QHLL 485
              .|...:|     ::.|..|.|.:|..|......|:.|    |..||             :.::
  Rat   225 NLANNQLSSLCPLETSPAPHPTSGSVGPSPPPAPAPTPLVGFSQFPQQLTPPRSPSPEPTVEDVI 289

  Fly   486 QQQQQQQHQPQLQQHHQLQQQP------HVSGVRVKTPSTPQTPQMCSIASSPSELGGCNSANNN 544
            .|..:...:.....|.:|...|      |.||      |.|.|...|      .|..||.|..|:
  Rat   290 SQVARAHREIFTYAHDKLGTSPGNFNANHASG------SPPATTPQC------WESQGCPSTPND 342

  Fly   545 NN-----NNNNSSSGNASGGSGV----SVGVVVVGGHQQLVGGSMVGMAGMGTDAHQVGMCHDGL 600
            ||     .:|.:.:|...|.|..    ..|......||.            .::.|::...|
  Rat   343 NNLLAAQRHNEALNGLRQGPSSYPPTWPSGPAHHSCHQP------------NSNGHRLCPTH--- 392

  Fly   601 AGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTV-PQNGIASTVAESLEFQKIWLWQQ 664
                    ||......:.|:.|....|:.:   |:..|:.: |......||.|        :|:.
  Rat   393 --------VYSAPEGKAPANGLRQGNTKNV---LLACPMNMYPHGRSGRTVQE--------IWED 438

  Fly   665 FSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTLDDGAYLTR 729
            ||...||.|:.:|||||.:|||.|.:|.||:.|:|.|.|||.:...|.|.|....|:   .:|:|
  Rat   439 FSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTV---MFLSR 500

  Fly   730 -----QQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRAREL 789
                 |:|..:...|.:||:.:|:..||:..|::.|:|||:|:||:::||:|:.....:.:.:|.
  Rat   501 TTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQET 565

  Fly   790 VAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            :..|||..:|::|   |........|..|:|:||:|...|...|
  Rat   566 LLRALRALVLKNR---PSETSRFTKLLLKLPDLRTLNNMHSEKL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	59/80 (74%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	64/180 (36%)
Nr1d1	NP_001106893.2	Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q3UV55	1..70		19/68 (28%)
		NR_DBD_REV_ERB	127..215	CDD:143540	60/91 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..286		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..336		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..384		6/39 (15%)
		NR_LBD	418..611	CDD:416257	69/203 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4846
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3239
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.860