Protein Alignment Eip78C and Nr1d1

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: NP_001106893.2
• Gene: Nr1d1 / 252917
• RGDID: 628827
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 694
• Identity: 212/694 - (30%)
• Similarity: 312/694 - (44%)
• Gaps: 167/694 - (24%)

  Fly   212 SNGGGALYTISSVHQFGPASNHNTSSSSP------SSSAAHSSPDSGCSS---ASSSGS-----S 262
            :|.||.:..|.|       |..:.|.:||      ||:.:..|...||.:   .|.:||     :
  Rat     8 NNTGGVITYIGS-------SGSSPSRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPA 65

  Fly   263 RSCGSSSASSSSSAVSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQ 327
            ||.|:...|.|..:..|:.||..||::|..|.:                  |...||...:...:
  Rat    66 RSFGTVPPSLSDDSSPSSASSSSSSSSSFYNGS------------------PPGSLQVAMEDSSR 112

  Fly   328 LQHPQQQQSFGLADSSSSNGSSN--NNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRS 390
            :              |.|.|:||  ..||:    .:.||||||.|||:||||.:|||||||||||
  Rat   113 V--------------SPSKGTSNITKLNGM----VLLCKVCGDVASGFHYGVHACEGCKGFFRRS 159

  Fly   391 IQKQIEY-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRE---------- 444
            ||:.|:| |||::..|.::|:||||||.||||||||.|||||:||:||:|||.::
  Rat   160 IQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQNAM 224

  Fly   445 --LNGAAAS-----SAAAGAPASLNVDDSTSSTLHPSHL----QQQQQ-------------QHLL 485
              .|...:|     ::.|..|.|.:|..|......|:.|    |..||             :.::
  Rat   225 NLANNQLSSLCPLETSPAPHPTSGSVGPSPPPAPAPTPLVGFSQFPQQLTPPRSPSPEPTVEDVI 289

  Fly   486 QQQQQQQHQPQLQQHHQLQQQP------HVSGVRVKTPSTPQTPQMCSIASSPSELGGCNSANNN 544
            .|..:...:.....|.:|...|      |.||      |.|.|...|      .|..||.|..|:
  Rat   290 SQVARAHREIFTYAHDKLGTSPGNFNANHASG------SPPATTPQC------WESQGCPSTPND 342

  Fly   545 NN-----NNNNSSSGNASGGSGV----SVGVVVVGGHQQLVGGSMVGMAGMGTDAHQVGMCHDGL 600
            ||     .:|.:.:|...|.|..    ..|......||.            .::.|::...|
  Rat   343 NNLLAAQRHNEALNGLRQGPSSYPPTWPSGPAHHSCHQP------------NSNGHRLCPTH--- 392

  Fly   601 AGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTV-PQNGIASTVAESLEFQKIWLWQQ 664
                    ||......:.|:.|....|:.:   |:..|:.: |......||.|        :|:.
  Rat   393 --------VYSAPEGKAPANGLRQGNTKNV---LLACPMNMYPHGRSGRTVQE--------IWED 438

  Fly   665 FSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTLDDGAYLTR 729
            ||...||.|:.:|||||.:|||.|.:|.||:.|:|.|.|||.:...|.|.|....|:   .:|:|
  Rat   439 FSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTV---MFLSR 500

  Fly   730 -----QQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRAREL 789
                 |:|..:...|.:||:.:|:..||:..|::.|:|||:|:||:::||:|:.....:.:.:|.
  Rat   501 TTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQET 565

  Fly   790 VAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            :..|||..:|::|   |........|..|:|:||:|...|...|
  Rat   566 LLRALRALVLKNR---PSETSRFTKLLLKLPDLRTLNNMHSEKL 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	59/80 (74%)
		NR_LBD_DmE78_like	659..854	CDD:132739	64/180 (36%)
Nr1d1	NP_001106893.2	Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q3UV55	1..70		19/68 (28%)
		NR_DBD_REV_ERB	127..215	CDD:143540	60/91 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..286		10/51 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..336		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..384		6/39 (15%)
		NR_LBD	418..611	CDD:472173	69/203 (34%)