DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eip78C and Rorb

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_666207.3	Gene:	Rorb / 225998	MGIID:	1343464	Length:	470	Species:	Mus musculus

Alignment Length:	535	Identity:	162/535 - (30%)
Similarity:	247/535 - (46%)	Gaps:	102/535 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 NGSSNNNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRDGKCLVIRL 410
            |......:|.:....:|||:||||:||.||||.:|||||||||||.|....|.|.|...||:.|.
Mouse     4 NQPKTKADGTAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRT 68

  Fly   411 NRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDSTSSTLHPSH 475
            ||||||:||.:|||:.|||||:|::||:.|:.|:               ||             :
Mouse    69 NRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRD---------------SL-------------Y 105

  Fly   476 LQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMCSIASSPSELGGCNS 540
            .:.|:.|..||:|:|||                 ||         :...:..:.||        |
Mouse   106 AEVQKHQQRLQEQRQQQ-----------------SG---------EAEALARVYSS--------S 136

  Fly   541 ANNNNNNNNNSSSGNASGGSGV----SVGVVVVGGHQQLVGGSMVGMAGMGT-------DAHQV- 593
            .:|..:|.|..:.|..:.|..:    |.|...:...|.....|.:.|.|:..       |...|
Mouse   137 ISNGLSNLNTETGGTYANGHVIDLPKSEGYYSIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVP 201

  Fly   594 ----------GMCHDGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIAS 648
                      |....|:..:..:....::|    ::|...|.||.|...:|..:..|..:  |.:
Mouse   202 NLFTYSSFNNGQLAPGITMSEIDRIAQNII----KSHLETCQYTMEELHQLAWQTHTYEE--IKA 260

  Fly   649 TVAESLEFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARL 713
            ..::|.|.    ||||.:.::|..:|.:||||||:.||.:..|:||::|:|.|..||.|..:.|.
Mouse   261 YQSKSREA----LWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRA 321

  Fly   714 INEATLT-LDDGAYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGL 777
            .|....| |.:|.|...|..:.|...|.||...:||..|.:..|::.||.|||:.||::.|||.|
Mouse   322 FNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWL 386

  Fly   778 SEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHLDWLRMNWTK 842
            .||:.:.:.:|.:..||:..|.::....    :.:..|.||||.:.::...|...|...:.:...
Mouse   387 IEPRKVQKLQEKIYFALQHVIQKNHLDD----ETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPD 447

  Fly   843 L---RLPPLFAEIFD 854
            :   ..|||:.|:|:
Mouse   448 IVNTLFPPLYKELFN 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	50/79 (63%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	66/198 (33%)
Rorb	NP_666207.3	NR_DBD_ROR	14..108	CDD:143526	54/121 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..127		11/61 (18%)
		NR_LBD_ROR_like	221..461	CDD:132737	77/253 (30%)
		AF-2	456..461		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010