Protein Alignment Eip78C and Nr1d1

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: NP_663409.2
• Gene: Nr1d1 / 217166
• MGIID: 2444210
• Length: 615
• Species: Mus musculus
• Alignment Length: 704
• Identity: 216/704 - (30%)
• Similarity: 317/704 - (45%)
• Gaps: 186/704 - (26%)

  Fly   212 SNGGGALYTISSVHQFGPASNHNTSSSSP------SSSAAHSSPDSGCSS---ASSSGS-----S 262
            :|.||.:..|.|       |..:.|.:||      ||:.:..|...||.:   .|.:||     :
Mouse     8 NNTGGVITYIGS-------SGSSPSRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPA 65

  Fly   263 RSCGSSSAS-SSSSAVSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQ 326
            ||.||:..| |..|:.||..||..||::|..|.:                  |...||...:...
Mouse    66 RSFGSAPPSLSDDSSPSSASSSSSSSSSSFYNGS------------------PPGSLQVAMEDSS 112

  Fly   327 QLQHPQQQQSFGLADSSSSNGSSN--NNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRR 389
            ::              |.|.|:||  ..||:    .:.||||||.|||:||||.:||||||||||
Mouse   113 RV--------------SPSKGTSNITKLNGM----VLLCKVCGDVASGFHYGVHACEGCKGFFRR 159

  Fly   390 SIQKQIEY-RCLRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSA 453
            |||:.|:| |||::..|.::|:||||||.||||||||.|||||:||:||:|||.::...|...||
Mouse   160 SIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSA 224

  Fly   454 AAGAPASLNVDDS---------TSSTLHP---------------------SHLQQQ--------- 479
                   :|:.::         ||.|.||                     |...||
Mouse   225 -------MNLANNQLSSLCPLETSPTPHPTSGSMGPSPPPAPAPTPLVGFSQFPQQLTPPRSPSP 282

  Fly   480 --QQQHLLQQQQQQQHQPQLQQHHQLQQQP------HVSGVRVKTPSTPQTPQMCSIASSPS--E 534
              ..:.::.|..:...:.....|.:|...|      |.||    :||          |::|.  |
Mouse   283 EPTMEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASG----SPS----------ATTPHRWE 333

  Fly   535 LGGCNSANNNNN-----NNNNSSSGNASGGSGV----SVGVVVVGGHQQLVGGSMVGMAGMGTDA 590
            ..||.||.|:||     .:|.:.:|...|.|..    ..|......||.            .::.
Mouse   334 SQGCPSAPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPTHHSCHQP------------NSNG 386

  Fly   591 HQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTV-PQNGIASTVAESL 654
            |::...|           ||......:.|:.|....|:.:   |:..|:.: |......||.|
Mouse   387 HRLCPTH-----------VYSAPEGEAPANSLRQGNTKNV---LLACPMNMYPHGRSGRTVQE-- 435

  Fly   655 EFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATL 719
                  :|:.||...||.|:.:|||||.:|||.|.:|.||:.|:|.|.|||.:...|.|.|....
Mouse   436 ------IWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQ 494

  Fly   720 TLDDGAYLTR-----QQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSE 779
            |:   .:|:|     |:|..:...|.:||:.:|:..||:..|::.|:|||:|:||:::||:|:..
Mouse   495 TV---MFLSRTTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMEN 556

  Fly   780 PKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            ...:.:.:|.:..|||..:|::|   |........|..|:|:||:|...|...|
Mouse   557 SASVEQLQETLLRALRALVLKNR---PSETSRFTKLLLKLPDLRTLNNMHSEKL 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	59/80 (74%)
		NR_LBD_DmE78_like	659..854	CDD:132739	64/180 (36%)
Nr1d1	NP_663409.2	Modulating	1..129		41/159 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..120		37/150 (25%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:30792350	1..70		19/68 (28%)
		Crucial for activation of GJA1	49..285		99/278 (36%)
		NR_DBD_REV_ERB	128..216	CDD:143540	60/91 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..286		8/50 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..337		9/38 (24%)
		NR_LBD	419..612	CDD:472173	69/203 (34%)