DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and Rara

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_001170773.1	Gene:	Rara / 19401	MGIID:	97856	Length:	462	Species:	Mus musculus

Alignment Length:	653	Identity:	161/653 - (24%)
Similarity:	229/653 - (35%)	Gaps:	245/653 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 GGGAL--YTISSVHQFGPASNHNTSSSSPSSSAAHSSPDSGCSSASSSGSSRSCGSSSASSSSSA 276
            |||.|  |.:.....|.|......|.....:|..|..|.||.|:.|
Mouse    12 GGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSLQHQLPVSGYSTPS------------------- 57

  Fly   277 VSSTISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHPQQQQSFGLAD 341
             .:||.:..||:..:| |:..|           ..|||
Mouse    58 -PATIETQSSSSEEIV-PSPPS-----------PPPLP--------------------------- 82

  Fly   342 SSSSNGSSNNNNGVSSKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRDGKCL 406
                            :.:.||.||.||:|||||||::||||||||||||||.:.|.|.||..|:
Mouse    83 ----------------RIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCI 131

  Fly   407 VIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDDSTSSTL 471
            :.::.||||||||.:||...|||::|||..|..|:..             ||   ..:.|.|.||
Mouse   132 INKVTRNRCQYCRLQKCFDVGMSKESVRNDRNKKKKE-------------AP---KPECSESYTL 180

  Fly   472 HPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMCSIASSPSELG 536
            .|       :...|.::.::.||...                         |.:|       :||
Mouse   181 TP-------EVGELIEKVRKAHQETF-------------------------PALC-------QLG 206

  Fly   537 GCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMAGMGTDAHQVGMCHDGLA 601
                    ....||||                    :|.|
Mouse   207 --------KYTTNNSS--------------------EQRV------------------------- 218

  Fly   602 GTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFS 666
                                                               ||:   |.||.:||
Mouse   219 ---------------------------------------------------SLD---IDLWDKFS 229

  Fly   667 ARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLI--NEATLTLDDGAYLTR 729
            ...|..:.:.|||||::|||...|..||:.|:|....::.:..:....  .:.|:|..||..|.|
Mouse   230 ELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294

  Fly   730 QQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEAL 794
            .|:.........:.:..|||.|....:.|.|.||.||:.|:..||..|.:|..:...:|.:.|||
Mouse   295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEAL 359

  Fly   795 RVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFSHLDWLRMNWTKLRLPPLFAEIFDIPKAD 859
            :|.:.:.|...|   .:.|.:..||.:|||:.||....:..|:|. ....:|||..|:.:..:..
Mouse   360 KVYVRKRRPSRP---HMFPKMLMKITDLRSISAKGAERVITLKME-IPGSMPPLIQEMLENSEGL 420

  Fly   860 DEL 862
            |.|
Mouse   421 DTL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	49/79 (62%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	62/196 (32%)
Rara	NP_001170773.1	Modulating	1..87		25/149 (17%)
		DUF3454	19..>68	CDD:371809	14/68 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..77		9/45 (20%)
		NR_DBD_RAR	82..166	CDD:143522	50/126 (40%)
		Hinge	154..182		12/43 (28%)
		NR_LBD_RAR	186..416	CDD:132735	77/372 (21%)
		Required for binding corepressor NCOR1	404..419		4/14 (29%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P10276	408..416		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..462		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2459
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940