DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and nhr-23

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_001020975.1	Gene:	nhr-23 / 172460	WormBaseID:	WBGene00003622	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	674	Identity:	170/674 - (25%)
Similarity:	265/674 - (39%)	Gaps:	145/674 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 GPASNHNTSSSSPSS--------SAAHSSP----DSGCSSASSSGSSRSCGSSSASSSSSAVSST 280
            || :.|.||....||        ..||:.|    :...:.|:.:..::|....|.|..:......
Worm     7 GP-NRHLTSVLEMSSFVYWPRSRQQAHNFPMQAVEQKLADATRTLHAKSSLQPSLSIETPKSKEN 70

  Fly   281 ISSGRSSNNSVVNPAATSSSVAHLNKEQQQQPLP--------TTQLQQQQQHQQQLQHPQQQQSF 337
            ..||..|:|.:.:| .|..|..:....::.:.:|        ..|:....:....:....:....
Worm    71 DESGCESSNCMFHP-HTIKSEPNFCFAREFKSVPDDFRIGGGDLQMGNNSKRLTCVIDTNRVDMA 134

  Fly   338 G-LADSSSSNGSSNNNNGVSSKSF--VPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRC 399
            | |.|:.|..|...|.:.:.|...  :||||||||:||.||||.:|||||||||||....:.|:|
Worm   135 GILPDNMSFRGLPENKSLLVSAQIEVIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSIVNYQC 199

  Fly   400 LRDGKCLVIRLNRNRCQYCRFKKCLSAGMSRDSVRYGRVPKRSRELNGAAA----SSAAAGAPAS 460
            .|...|:|.|:|||||||||.|||:..|||||:|::||:.|:.||......    ..||.|....
Worm   200 PRQKNCVVDRVNRNRCQYCRLKKCIELGMSRDAVKFGRMSKKQREKVEDEVRMHKELAANGLGYQ 264

  Fly   461 LNVDDSTSSTLHPSHLQQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQM 525
            ....|.:....|||:...|                .:..|:.......|:|..:...:||.||.
Worm   265 AIYGDYSPPPSHPSYCFDQ----------------SMYGHYPSGTSTPVNGYSIAVAATPTTPM- 312

  Fly   526 CSIASSPSELGGCNSANNNNNNNNNSSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMAGMGTDA 590
                  |..:.|   |..::.|.....:..|:|||..|..|
Worm   313 ------PQNMYG---ATPSSTNGTQYVAHQATGGSFPSPQV------------------------ 344

  Fly   591 HQVGMCHDGLAGTANELTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIASTVAESL- 654
                         ..|.....||...:|.|   .|||              .|:|:.:...:.:
Worm   345 -------------PEEDVATRVIRAFNQQH---SSYT--------------TQHGVCNVDPDCIP 379

  Fly   655 EFQKIWLWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINE--- 716
            ...:...|:.|:..:.|.:|.|:||||.:.||.:..|:.|:.|:|...||:.|...|...|.
Worm   380 HLSRAGGWELFARELNPLIQAIIEFAKSIDGFMNLPQETQIQLLKGSVFELSLVFAAMYYNVDAQ 444

  Fly   717 -----------ATLTLDDGAYLTRQQLEILYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLL 770
                       |.|..:|.|     :::::.:   ||..|.....|..:   .:|:.|.:|.::|
Worm   445 AVCGERYSVPFACLIAEDDA-----EMQLIVE---VNNTLQEIVHLQPH---QSELALLAAGLIL 498

  Fly   771 ----ASDRAGLSEPKVIGRARELVAEALRVQILRSRAGSPQALQLMPALEAKIPELRSLGAKHFS 831
                :|...|:.:...|..| |.:..||...::.........:..:..:|.:|   |.....|..
Worm   499 EQVSSSHGIGILDTATIATA-ETLKNALYQSVMPRIGCMEDTIHRIQDVETRI---RQTARLHQE 559

  Fly   832 HLDWLRMN--WTKLRLPPLFAEIF 853
            .|...||:  .:..:||.|:.|:|
Worm   560 ALQNFRMSDPTSSEKLPALYKELF 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	51/79 (65%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	51/215 (24%)
nhr-23	NP_001020975.1	NR_DBD_ROR	156..250	CDD:143526	54/93 (58%)
nhr-23	NP_001020975.1	NR_LBD	384..580	CDD:299703	49/210 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010