Protein Alignment Eip78C and nr1h4

DIOPT Version :10

• Sequence 1: NP_524195.2
• Gene: Eip78C / 40345
• FlyBaseID: FBgn0004865
• Length: 862
• Species: Drosophila melanogaster
• Sequence 2: XP_002936891.3
• Gene: nr1h4 / 100489310
• XenbaseID: XB-GENE-487942
• Length: 478
• Species: Xenopus tropicalis
• Alignment Length: 643
• Identity: 142/643 - (22%)
• Similarity: 217/643 - (33%)
• Gaps: 223/643 - (34%)

  Fly   254 SSASSSGSSRSCGSSSASSSSSAVSSTISSGRSSNNSVVNPA------ATSSSVAHLNKEQQQQP 312
            |:.|...:|...|..|..::||...|...|..|..|.|..|:      ::|||..|||.....
 Frog    17 SAISVLDTSEFIGLHSVHTNSSDHDSQGPSFSSPYNHVQYPSVHQSMTSSSSSPYHLNSNYYS-- 79

  Fly   313 LPTTQLQQQQQHQQQLQHPQQQQSFGLADSS---SSNGSSNNNNGVS---------------SKS 359
                            ||.::..:.|:.|..   |.|..|.:.:.:|               .|.
 Frog    80 ----------------QHAEEWCANGIYDLKRIPSENLYSIDTDIISLPATKKHRVSPRVGRVKG 128

  Fly   360 FVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCL 424
            ...|.||||.||||||...:||||||||||||.|...|:|...|.|.:....|.:||.||.:||.
 Frog   129 DELCVVCGDNASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCEMDMYMRRKCQECRLRKCK 193

  Fly   425 SAGMSRDSVRYGRVPKRSRELNGAAASSAAAGAPASLNVDD-----STSSTLHPSHLQQQQQQHL 484
            ..||..:.: ...:..:|:.|...|...:.......::..:     ||:.|...:....|:|.:|
 Frog   194 QMGMLAECL-LTEIQCKSKRLRKHAKPQSEKSFQEDIDGHETKQVTSTTKTNQENTELTQEQMNL 257

  Fly   485 LQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKTPSTPQTPQMCSIASSPSELGGCNSANNNNNNNN 549
            ||                     :|....||.    :.||  |:|:
 Frog   258 LQ---------------------YVMDSHVKN----RLPQ--SLAT------------------- 276

  Fly   550 NSSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMAGMGTDAHQVGMCHDGLAGTANELTVYDVIM 614
                                         .::....||:|.:.|.:
 Frog   277 -----------------------------RLILQEDMGSDDNFVFL------------------- 293

  Fly   615 CVSQAHRLNCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFSARVTPGVQRIVEF 679
                        ||..||.                                       ||.:|||
 Frog   294 ------------TEMATRH---------------------------------------VQILVEF 307

  Fly   680 AKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATLTLDDGAYLTRQQLEILYD------- 737
            .|::|||.....:||:.|:|....|......|.|.|..         |..:..::|.:
 Frog   308 TKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAELFNRK---------LLERHTDVLEERIRKSGI 363

  Fly   738 -SDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQILRS 801
             .|::|.:.:|..::....:.:.|..|.:|:|:|..||..|.:.:.:.:.:|.....|.....|.
 Frog   364 SHDYINPMFHFYKSVGELKMVEEEYALLTAVVILTPDRQYLKDKESVEKLQETFLHILEKICKRC 428

  Fly   802 RAGSPQALQLMPALEAKIPELRSLGAKHFS--HLDWLRMNW--TKLRLPPLFAEIFDI 855
            ...:||.   ...|..::.|||:     ||  |.|.| |:|  ...:..||..||:|:
 Frog   429 HPDNPQH---FARLLGRLTELRT-----FSHHHADML-MSWRVNDHKFTPLLCEIWDV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_524195.2	NR_DBD_DmE78_like	363..443	CDD:143539	37/79 (47%)
		NR_LBD_DmE78_like	659..854	CDD:132739	50/206 (24%)
nr1h4	XP_002936891.3	NR_DBD_FXR	129..212	CDD:143520	38/83 (46%)
		NR_LBD	252..473	CDD:472173	68/383 (18%)