DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip78C and nr1d2

DIOPT Version :9

Sequence 1:	NP_001246862.1	Gene:	Eip78C / 40345	FlyBaseID:	FBgn0004865	Length:	862	Species:	Drosophila melanogaster
Sequence 2:	NP_001361696.1	Gene:	nr1d2 / 100101761	XenbaseID:	XB-GENE-478410	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	197/684 - (28%)
Similarity:	295/684 - (43%)	Gaps:	175/684 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 HNTSS--SSPSSSAAHSSPDSGCSSASSSGSSRSCGSSSASSSSSAVSSTISSGRSS-NNSVVNP 294
            :||.|  :..|||::.||| |.|.|.||:.|.:|  |||..||.|:.||..|.|.|| |.|....
Frog     3 NNTGSVITYISSSSSASSP-SSCHSDSSNSSFQS--SSSLPSSPSSSSSEGSGGGSSGNGSDRKT 64

  Fly   295 AATSSSVAHLNKEQQQQPLPTTQLQQQQQHQQQLQHPQQQQSFGLADSSSSNGSSNNNNGVS--- 356
            :.::..||..:::.::.                    ||..:..:..:.:|.......:|..
Frog    65 SLSNEGVACGHRDSKRN--------------------QQVDTLCIKTTYTSAAVLTKGHGTCPSK 109

  Fly   357 -SKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEY-RCLRDGKCLVIRLNRNRCQYCR 419
             |...:.||||||.|||:||||.:|||||||||||||:.|:| :||::..|.:||:||||||.||
Frog   110 ISGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNESCSIIRINRNRCQQCR 174

  Fly   420 FKKCLSAGMSRDSVRYGRVPKRSRE--------LNGAAASSAAAGAPASLNVDDSTSSTLHPSHL 476
            ||||||.|||||:||:||:|||.::        :.....|:..:|:.....:.|..:    ||.|
Frog   175 FKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQTVMKTMMSNQFSGSSLQETLPDYQA----PSSL 235

  Fly   477 QQQQQQHLLQQQQQQQHQPQLQQHHQLQQQPHVSGVRVKT----PSTPQTPQMCSIASS------ 531
            |                .|.........:..|.|..:..|    ||.|..|.:.|:..|
Frog   236 Q----------------LPHTALEKMASKTQHYSENKALTPPLPPSLPHPPPVMSMDISKEDVIG 284

  Fly   532 -------------------PSELG-------------------------GC---------NSANN 543
                               |||.|                         .|         |.|:|
Frog   285 TVTGAHRETFMYNQVPVEFPSEAGRQQEEIHSNVTHRNNDHMRNGIIAAHCPVNKSKQYLNEADN 349

  Fly   544 NNN--NNNNSSSGNASGGSGVSVGVVVVGGHQQLVGGSMVGMAGMGTDAHQVGMCHDGLAGTANE 606
            :.|  :..|......|.|..:|.|    ..|:..:...|:.:    :..:.|.:|:.|
Frog   350 DRNFMHYPNGPVNCFSNGQNISSG----WSHRGCISEKMLDV----SHVNSVNLCNRG------- 399

  Fly   607 LTVYDVIMCVSQAHRLNCSYTEELTRELMRRPVTVPQNGIASTVAESLEFQKIWLWQQFSARVTP 671
                         .|::      |...:...|...|......            :|::||...||
Frog   400 -------------RRMH------LVCPMSMTPFMDPNKSGTQ------------IWEEFSMSFTP 433

  Fly   672 GVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLIN--EATLTLDDGAYLTRQQLEI 734
            .|:.:|:|||.:|||.|.:|.||:.|:|.|.|||.:...|.|.:  |.|:|...|...:..:|.:
Frog   434 AVKEVVDFAKGIPGFKDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDELRL 498

  Fly   735 LYDSDFVNALLNFANTLNAYGLSDTEIGLFSAMVLLASDRAGLSEPKVIGRARELVAEALRVQIL 799
            :...|.:|::..|:..|:|..||:.|:.||:|:||:::||:|:.....:...:|.:..|||..|:
Frog   499 MGAGDLLNSVFEFSEKLSALQLSEEEMSLFTAVVLVSADRSGIENVNSVEALQETLLRALRTLIM 563

  Fly   800 RSRAGSPQALQLMPALEAKIPELRSLGAKHFSHL 833
            |:.......   ...|..|:|:||||...|...|
Frog   564 RNHQNEAST---FTKLLLKLPDLRSLNNMHSEEL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip78C	NP_001246862.1	NR_DBD_DmE78_like	363..443	CDD:143539	59/80 (74%)
Eip78C	NP_001246862.1	NR_LBD_DmE78_like	659..854	CDD:132739	61/177 (34%)
nr1d2	NP_001361696.1	NR_DBD_REV_ERB	112..200	CDD:143540	59/87 (68%)
nr1d2	NP_001361696.1	NR_LBD_REV_ERB	412..599	CDD:132738	63/198 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3010
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050