DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10508 and wwc3

DIOPT Version :9

Sequence 1:	NP_001246859.1	Gene:	CG10508 / 40342	FlyBaseID:	FBgn0037060	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001103940.1	Gene:	wwc3 / 566492	ZFINID:	ZDB-GENE-070209-229	Length:	1148	Species:	Danio rerio

Alignment Length:	789	Identity:	149/789 - (18%)
Similarity:	257/789 - (32%)	Gaps:	256/789 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDPRGRSYRQLQNERCSTESIALQQLVSQPQTSHNS 73
            ::|.||:..|||..| .|||:::.|..|:|:|| ..:|| :.||...|.:    :|:|...:...
Zfish    63 ELPLGWEVVYDQQVG-VYYIDHINKTTQIENPR-TQWRQ-EQERMLKEYL----VVAQEALNAKK 120

  Fly    74 SPYHVHPSNNLTA---IRAFQERQQPTLHNISTSPLLSASSRGH--LEMSSPLPFQRARVGPNLS 133
            ..|.:.......|   ::.|.:..|....:|::|...|:|:..:  .::.:.:..:|.|    ||
Zfish   121 EMYQIKQQRLELAQQEMQLFNQLTQDDNRSITSSHSGSSSNAKYDPDQIKAEIACRRER----LS 181

  Fly   134 R--------RSTIQ--ETSFTTQAETDAVVTKIQNMFPTAGENHIRLLLKRYYNSEA-VVVSALQ 187
            |        |..:|  |....|..|.|..::..|.               .|...|| .:.|.|:
Zfish   182 RLKQELAQMRQELQYKEMGVETLQEIDRKMSSSQT---------------NYKLDEAQAIFSELR 231

  Fly   188 VEKHPVTMPGPFVTPPSQRHLFHSGSAFYMTPPARRPDTVAS------------RRTSRTASPLP 240
            ..|..::                       |....|.|.:.|            ...:..|..|.
Zfish   232 SIKKAIS-----------------------TGEKERQDLIQSLAKLTLNFCDSINEVTNNAESLA 273

  Fly   241 G-----------------GRFGSLVSVQSGPGGPSGHQAVLPPSSAVPPALHGSPLWRSSPRPHS 288
            .                 |.|||                  ..||.:...:..|  |:     :.
Zfish   274 DSCSVQQYTDAGCQTDLMGEFGS------------------QESSLLADRVKLS--WQ-----YE 313

  Fly   289 SPKMKLRYMKNIFPKADEEL------------LLDILANAD---------NNVQFASEKLISLGY 332
            ..|.|:..:::...:.|.|.            .|.:|...:         :..|.:|:.|:.|..
Zfish   314 EAKKKMSSIQHQLAQLDSESWSGRAEADRDWDCLQLLREKETLLQELTLLSQQQHSSDTLLQLQE 378

  Fly   333 TKR----DMQQPHRPNNRPPDLNQDQEAGGDQSGVHIPLRPKEYT----EEEKTKMQTLLKEKYP 389
            .||    ::|:.|          ..|..|.:|   .|.|:.|...    .||.|::.|.|..:
Zfish   379 EKRRLQDEVQRAH----------SAQSQGANQ---RILLQEKRNVLMRQLEEATRITTYLHSQ-- 428

  Fly   390 QIAERIILMALESVNYAEDRATQILQIVQDEDEQREQKQAPMNPKHLDL------KKTTGTEQID 448
                   |.:|.:.|.....::....:..........:.:..:....|:      .:|.|:..:.
Zfish   429 -------LKSLSASNLTVSSSSSRGSLASSRGSLASSRGSLSSVSFTDIYGLPQYDRTEGSSDVL 486

  Fly   449 GANEKDSLPAVVEPTTSSKPKPPHKRHILPSINVTTPSTFTTQIILAQATPTPTPTAEEMKLETH 513
            ..:.:..||  :|..:|.....|.:.|       .||.:.|:                 :...:.
Zfish   487 DPSFRYLLP--LESHSSGSAYGPKRSH-------DTPQSLTS-----------------LSSRSS 525

  Fly   514 LSSISSASS--SHSYASPPQSPRIFQ--QSYERLTTKSILAKSGHNHFGHQSDTNNYSIDG---- 570
            |||:|..||  ...|.|.||...:.|  :.|..:.::.:||:........|..| ..|.||
Zfish   526 LSSLSPPSSPMDTPYHSAPQDCPLAQMTEEYMEVASRGLLAEGLRTQSQAQQHT-TLSGDGEVGI 589

  Fly   571 -----YLHGSSNASSYSSYSASMTSSSLVSSAQSNSSSIARRPA--------------FESRART 616
                 .|.|.|:..:....:.|.|..:|...:.|.:|..|||.:              ||:.:|:
Zfish   590 AATAHLLEGKSHRDAALQGTHSSTGVTLRCKSASRTSRRARRVSAGVNEDVLATDSGVFEAWSRS 654

  Fly   617 KTDSLKHRQHSLGNSHNSESAEFQSIIERMASLGPNSQLSKGADENLLLADYVTWNGPNTKLLQK 681
            :|:             .||...|...:....|...:.|:.       ||.|      .|::.|..
Zfish   655 RTE-------------ESEEVSFAQDVTVAVSEPVHIQIG-------LLYD------SNSRFLLL 693

  Fly   682 QITQGPNAS 690
            .:.|..|.|
Zfish   694 HVLQMRNLS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	8/56 (14%)
wwc3	NP_001103940.1	WW	17..46	CDD:278809
		WW	64..93	CDD:278809	13/29 (45%)
		C2_Kibra	677..800	CDD:176062	9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14791
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100