DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10508 and WWC3

DIOPT Version :9

Sequence 1:	NP_001246859.1	Gene:	CG10508 / 40342	FlyBaseID:	FBgn0037060	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	792	Identity:	151/792 - (19%)
Similarity:	245/792 - (30%)	Gaps:	274/792 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QLEDPRGRSYRQLQNERC-----STESIALQQ----LVSQPQTSHNSSPYHVHPSNNLTAIRAFQ 91
            :||:.|.|...:|:..|.     :||.|.||:    |:.|.:.:...:.|......:|.|
Human   299 RLEEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCA----- 358

  Fly    92 ERQQPTLHNISTSPLLSASSRGHLEMSSPLPFQRARVGPNLSRRSTIQETSFTTQAETDAVVTKI 156
                      ||..:.|.||||.|..|.         |...|.|.::...|||
Human   359 ----------STLTVSSGSSRGSLASSR---------GSLASSRGSLSSVSFT------------ 392

  Fly   157 QNMFPTAGENHIRLLLKRYYNSEAVVVSALQVEKHPVTMPG---PFVTPPSQRHLFHSGSAFYMT 218
             :::.          |.:|...:|.....|:.:..|....|   ||..||.... ||.......|
Human   393 -DIYG----------LPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSG-FHKQRRSLDT 445

  Fly   219 PPARRPDTVASRRTSRTASP---------LPGGRFGSLVSVQSGPGGPS--------GHQAV--- 263
            |.:..  :::||.:..:.||         ||..|...|..:.....||.        .|.:.
Human   446 PQSLA--SLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAHASAMGD 508

  Fly   264 --LPPSSAVPPALHGSPLWRSSPRPHSSPKMKLRYMKNIFPKADEELLLDILAN----ADNNVQF 322
              ||..:|:.|  ||.|.....|.....|.........:..:.|....|:..|.    ..::...
Human   509 EDLPGMAALQP--HGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSL 571

  Fly   323 ASEKLISLGYTKR--DMQQP---HRPNNRPPDLNQD--QEAGGDQSGVHI--------------- 365
            ||:..:....|||  |.::|   ...:|..|.::..  :::|.:...||:
Human   572 ASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAGLAVKEDC 636

  Fly   366 ---------PL---RPKEYTEEE-KTKMQTLLKEKY----------------------PQIAERI 395
                     ||   .|..|..:. :.::..:..|.:                      ||:.|.
Human   637 KVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVCSVTPQLQEE- 700

  Fly   396 ILMALESVNYAE----------------------------------------------------- 407
             |:.:..:|.|:
Human   701 -LLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAHTISISGKTDAVT 764

  Fly   408 ---DRATQILQIVQDEDEQREQKQAPMNPKHLDLKKTTGTEQIDGANEK----DSLPAVVEPTTS 465
               .|.|..||.|:.|..:...|......:.|::::.  .||.:..:|:    ||:.:.....|.
Human   765 VLLARTTAQLQAVERELAEERAKLEYTEEEVLEMERK--EEQAEAISERSWQADSVDSGCSNCTQ 827

  Fly   466 SKPKPPHKRHILPSINVTTPSTFTTQIIL-----AQATP------TPTP-------TAEEMKLET 512
            :.|..|.            |.......||     |||.|      .|:|       ..|::.||.
Human   828 TSPPYPE------------PCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEE 880

  Fly   513 HLSSISSASSSHSYASPPQSPRIFQQS--YERLTTKSILAKSGHNHFGHQSDTNNYSIDGYLHGS 575
            ..|.:....|..:..||      |.:|  ..|..|.|..|:|.:....::||::          |
Human   881 AASLVKERPSRRARGSP------FVRSGTIVRSQTFSPGARSQYVCRLYRSDSD----------S 929

  Fly   576 SNASSYSSYSASMTSSSLVSSAQSNSSSIARRPAFESRARTKTD------SLKHRQHSLGNSHNS 634
            |.....|.:..:......:...||..||:|     |..|||..|      :.:.||..|    |.
Human   930 STLPRKSPFVRNTLERRTLRYKQSCRSSLA-----ELMARTSLDLELDLQASRTRQRQL----NE 985

  Fly   635 ESAEFQSIIERM 646
            |....:.:.:|:
Human   986 ELCALRELRQRL 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	5/39 (13%)
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		9/29 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		17/68 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		9/35 (26%)
		C2_Kibra	602..725	CDD:176062	15/124 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14791
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100