DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10508 and Wwc2

DIOPT Version :9

Sequence 1:	NP_001246859.1	Gene:	CG10508 / 40342	FlyBaseID:	FBgn0037060	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	799	Identity:	152/799 - (19%)
Similarity:	266/799 - (33%)	Gaps:	259/799 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDP----RGRSYRQLQNERCSTESIALQQLVSQPQT 69
            ::|.||:..:|...| .|||:::.|..|:|||    ||...:.|::..    |:|...|.:|.:.
Mouse    58 ELPWGWEAGFDPQIG-AYYIDHINKTTQIEDPRKQWRGEQEKMLKDYL----SVAQDALRTQKEL 117

  Fly    70 SHNSSPYHVHPSNNLTAIRAFQERQQPTLHNISTSPLLSASSRGHLEMSSPLPFQRARVGPNLSR 134
                  |||.......|:..:.....                 .:.|.||             |.
Mouse   118 ------YHVKEQRLALALDEYVRLND-----------------AYKEKSS-------------SH 146

  Fly   135 RSTIQETSFTTQAETDAVVTKIQNMFPTAGENHIRLLLKRYYNSEAVVVSALQVEKHPVTMPGPF 199
            .|....:|.:|:.:.|.:..:|.                         .:.|:|:|
Mouse   147 TSLFSGSSSSTKYDPDILKAEIS-------------------------TTQLRVKK--------- 177

  Fly   200 VTPPSQRHLFHSGSAFYMTPPARRPDTVASRRTSRTASPLPGGRFGSLVSVQSGPGGPSGHQ--- 261
                .:|.|.|           .:.:.:..::...|...:.          :...||.||::
Mouse   178 ----LKRELSH-----------MKQELLYKQQGFETLQQID----------EKMSGGQSGYELNE 217

  Fly   262 --AVLPPSSAVPPALHGSPLWRSSPRPHSSPKMKLRYMKNIFPKADEELLLDILANADNNVQFAS 324
              |:|....::..|:            .|..|.|...|::: .|..|...||
Mouse   218 AKAILTELKSIRKAI------------SSGEKEKQDLMQSL-AKLQERFHLD------------- 256

  Fly   325 EKLISLGYTKRDMQQPHRPNNRPPDLNQDQEAGGDQSGV--HIPLRPK-----------EYTEEE 376
               .::|.::.|::.  .|.|....|::.....|.|:.:  .|.:|.:           :|.|.:
Mouse   257 ---QNMGSSEPDLRS--SPVNSHLSLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAK 316

  Fly   377 ------KTKMQTLLKEKYPQI----AERIILMALESVNYAEDRATQILQIVQDEDEQREQKQAPM 431
                  |.::..|..|.:|..    .|:::|     :|..|:...::..|...:..|.|.::...
Mouse   317 RSMANLKIELSKLDGEAWPGALDIEKEKLML-----INEKEELLKELQFITPQKRSQEELERLEA 376

  Fly   432 NPKHLDLKKTTGTEQIDGANEKDSLPAVVEPTTSSKPKPPHKRHILPSINVTTPSTFTTQIILAQ 496
            ..:||:       |::..|....|     ...|........::.:|..:..||  ..||.:.
Mouse   377 ERQHLE-------EELMAARGSPS-----RALTERLKLEEKRKELLQKLEETT--KLTTSLY--- 424

  Fly   497 ATPTPTPTAEEMKLETHLSSISSASSSHSYASPPQSPRIFQQ-SYERLTTKSILAKSGHNHFGHQ 560
                    ::...|.:...|:||.||..|.||...|.....: |...|::..:...|.    |.|
Mouse   425 --------SQLQSLSSSTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSSELYYSSQ----GDQ 477

  Fly   561 SDTN-NYSID-------GY--------LHGSSNASSYSSYSAS------MTSSSLVSSAQSNSSS 603
            .||: .|.:|       ||        :|.:....|.|....|      :|:||..:.....|.|
Mouse   478 MDTDYQYKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLCGVGVTASSHTTPLTEASKS 542

  Fly   604 IARRPAFESRARTKTDSLKHRQHSL-------GNSHNSESAEFQSIIE------RMA--SLGPNS 653
            :|     ...:|:...||......|       |:||::...:|.:..|      |.|  .||.|.
Mouse   543 VA-----SLSSRSSLSSLSPPGSPLVLDSVFPGSSHDTSPHQFPTDFEDCELSRRFADVGLGENQ 602

  Fly   654 QL----SKGADENLL----LADYVTWNGPNTKL------LQKQITQGPNASLLTDRTYKPRGGKS 704
            .|    |.||.:.||    |:|.     |...|      ::|.:.:.....|..|:|.:.....|
Mouse   603 ALLDSDSGGASQPLLEDKGLSDC-----PGELLCEGATDVEKSLPKRRGLHLRGDKTTRVSAAAS 662

  Fly   705 ELCKGPQSGLAKGSIYAQG 723
            :......||:.:.|:...|
Mouse   663 DESVAGDSGVYEASMKQPG 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	7/35 (20%)
Wwc2	NP_598552.2	WW	12..41	CDD:278809
		WW	59..88	CDD:278809	11/29 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		9/25 (36%)
		C2_Kibra	699..822	CDD:176062
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963
		Phage_Nu1	<1088..>1146	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14791
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100