DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10508 and Wwc2

DIOPT Version :9

Sequence 1:	NP_001246859.1	Gene:	CG10508 / 40342	FlyBaseID:	FBgn0037060	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001102581.1	Gene:	Wwc2 / 498630	RGDID:	1559427	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	157/823 - (19%)
Similarity:	264/823 - (32%)	Gaps:	307/823 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDPRGRSYRQLQNERCSTE-SIALQQLVSQPQTSHN 72
            ::|.||:..:|...| .|||:::.|..|:|||| :.:|..|.:..... |:|...|.:|.:.
  Rat    58 ELPWGWEAGFDPQIG-AYYIDHINKTTQIEDPR-KQWRGEQEKMLKDYLSVAQDALRTQKEL--- 117

  Fly    73 SSPYHVHPSNNLTAIRAFQERQQPTLHNISTSPLLSASSRGHLEMSSPLPFQRARVGPNLSRRST 137
               |||.......|:..:.....                 .:.|.||             |..|.
  Rat   118 ---YHVKEQRLALALDEYVRLND-----------------AYKEKSS-------------SHTSL 149

  Fly   138 IQETSFTTQAETDAVVTKIQNMFPTAGENHIRLLLKRYYNSEAVVVSALQVEKHPVTMPGPFVTP 202
            ...:|.:|:.:.|                    :||...::..:.|..|:.|          ::.
  Rat   150 FSGSSSSTKYDPD--------------------ILKAEISTTRLRVKKLKRE----------LSQ 184

  Fly   203 PSQRHLFHSGSAFYMTPPARRPDTVASRRTSRTASPLPGGRFGSLVSV-QSGPGGPSGHQ----- 261
            ..|..|:....                              |.:|..: :...||.||::
  Rat   185 MKQELLYKQQG------------------------------FETLQQIDEKMSGGQSGYELSEAK 219

  Fly   262 AVLPPSSAVPPALHGSPLWRSSPRPHSSPKMKLRYMKNIFPKADEELLLDILANADNNVQFASEK 326
            |:|....::..|:            .|..|.|...|::: .|..|...||
  Rat   220 AILTELKSIRKAI------------SSGEKEKQDLMQSL-AKLQERFHLD--------------- 256

  Fly   327 LISLGYTKRDMQQPHRPNNRPPDLNQDQEAGGDQSGV--HIPLRPKEYTEEEKTKMQTLLKEKYP 389
             .::|.::.|::  ..|.|....|::.....|.|:.:  .|.:|.:.
  Rat   257 -QNMGSSEPDLR--CSPVNSHLSLSRQTLDAGSQTSISGDIGVRSRS------------------ 300

  Fly   390 QIAERIILMALESVNYAEDRATQILQIVQDEDEQREQKQAPMNPKHLDLKKTTGTEQIDGA--NE 452
            .:||::.|    |:.|                  .|.|::..|.| ::|.|..| |...||  .|
  Rat   301 NLAEKVRL----SLQY------------------EEAKRSMANLK-IELSKLDG-EAWPGALDVE 341

  Fly   453 KDSLPAVVEPTTSSKPKPPHKRHILPSINVTTPSTFT---------------TQIILAQATPTPT 502
            |:.|..:.|           |..:|..:...||...|               .:::.|:..|: .
  Rat   342 KEKLMLINE-----------KEELLKELQFITPQKRTQDELERLEAERQRLEEELVAARGLPS-R 394

  Fly   503 PTAEEMKLE-----------------THL-SSISSASSSHSYASPPQSPRIFQQSYERLTTKS-- 547
            ..||.:|||                 |:| |.:.|.|||....|...|......|...|.|.|
  Rat   395 ALAERLKLEEKRKELLQKLEETTKLTTYLYSQLKSLSSSTLSMSSGSSLGSLASSRGSLNTSSRG 459

  Fly   548 ---ILAKSG--HNHFGHQSDTN-NYSID-------GY--------LHGSSNASSYS--------- 582
               .|:.|.  ::..|.|.||: .|.:|       ||        :|.:....|.|
  Rat   460 SLNSLSSSDLYYSSQGDQMDTDYQYKLDFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQSGLCG 524

  Fly   583 ------SYSASMT-SSSLVSSAQSNSSSIARRPAFESRARTKTDSLKHRQHSLGNSHNSESAEFQ 640
                  |::..:| :|..|:|..|.||..:..|.........|..        |:||::...:|.
  Rat   525 LGVAATSHTPPLTEASKSVTSLSSRSSLSSLSPPGSPLVLDSTFP--------GSSHDTSPHQFT 581

  Fly   641 SIIERMASLGPNSQLSK-----GADENLLLADYVTWNGPNTKLL--------------------Q 680
            :.:|       :.:||:     |..||.:|.|..: .||:..||                    :
  Rat   582 ADLE-------DCELSRHFADIGLGENQVLLDSDS-GGPSQSLLEDKDLDECTGGLLYEGSADVE 638

  Fly   681 KQITQGPNASLLTDRTYKPRGGKSELCKGPQSGLAKGSIYAQG 723
            |.:.:.....|..|:|.:.....|:......||:.:.|:...|
  Rat   639 KSLPKRRGLHLRGDKTARVSAAASDESVAGDSGVYEASVKQPG 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	7/35 (20%)
Wwc2	NP_001102581.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809	11/29 (38%)
		DUF342	<283..385	CDD:302792	28/154 (18%)
		YlqD	351..>420	CDD:287979	12/69 (17%)
		C2_Kibra	699..822	CDD:176062
		Phage_Nu1	<1095..>1153	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14791
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100