DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10508 and kibra

DIOPT Version :9

Sequence 1:	NP_001246859.1	Gene:	CG10508 / 40342	FlyBaseID:	FBgn0037060	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	841	Identity:	174/841 - (20%)
Similarity:	278/841 - (33%)	Gaps:	275/841 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDPRGRSYRQLQNERCSTESIALQQLVSQPQTSHNS 73
            ::|.||:..||...|. ||||:|.::.|||||| :.::.:|.:..|....|     :|.|..:..
  Fly   102 ELPMGWEESYDPNIGP-YYINHLAQSTQLEDPR-QEWKTVQEQMLSDYLSA-----AQDQLENKR 159

  Fly    74 SPYHVHPSNNLTAIRAFQERQQPTLHNISTSPLLSASSRGHLEMSSPLPFQRARVGPNLSRRSTI 138
            ..:.|.....|.|    ||.........|.|.|.|:||    .||...| :..|....|:|....
  Fly   160 EMFDVKQQRLLWA----QEEYNHLKLAASRSSLCSSSS----SMSRHDP-ELLRADLMLARERVH 215

  Fly   139 QETSFTTQAETDAVVT-KIQNMFPTAGENHIRLLLKRYYN-SEAVVVSALQVEKHPVTMPGPFVT 201
            |.....|....|...| :..|...:.||. |.......|: :|...:....::.|...:.|..|.
  Fly   216 QLKQELTHITNDISYTERGMNTLYSVGEK-INARENGCYDIAEVHAIREEMLKVHKSLVSGEKVR 279

  Fly   202 PPSQRHLFHSGSAFYMTPPARRPDTVASRRTSRTASPLPGGRFGSL-VSVQSGPGGPSGHQAVLP 265
            ....|.|....:..     .|:.   .|...|..|||     |..: |:.|:...|.||..
  Fly   280 EELMRSLVQIKNEL-----GRQQ---ISEENSDLASP-----FDRVCVASQTDLCGSSGEN---- 327

  Fly   266 PSSAVPPALHG--------SPLWRSSP-RPHSSPKMKLR-----YMKNIFP---KADEELLLDI- 312
                    |:|        ...|:.:. |.|..   ||:     :::.|.|   ::|::.:|.|
  Fly   328 --------LNGGARFAEMAKTKWQYAEWRKHIK---KLQQQLADHVERIEPGQLESDKDRILLIQ 381

  Fly   313 ----LANADNNVQFAS----EKLISLGYTKRDMQQPHRPNNRPPDLNQDQEAGGDQSGVHIPLRP 369
                |.|..|::...|    ||.: :..|:..:::         ||.:..||  :.:.|...||.
  Fly   382 EKEKLLNDLNSISLKSRSEEEKRV-IHQTRHKLEE---------DLKEAYEA--NNTCVANRLRF 434

  Fly   370 KEYTEEEKTKMQTLLKEKYPQIAERIILMALESV-----------------------------NY 405
            .|..:....|:|..||.. ..:.||:...:.||.                             .:
  Fly   435 HEEKQLLLDKLQEALKST-KLLEERLKSFSSESTFSISSGSSLGSLSTASSKSALSFTDIYIDPF 498

  Fly   406 AEDRATQIL-------QIVQDEDEQR--------EQKQA----------------PMNPKHLDLK 439
            |.|....::       ::.|...:||        :|:|:                |.:|    :|
  Fly   499 AVDSPIDVVDLRRRSQRLFQQHQQQRLHPVHPVLQQQQSAEVTLSPRSSLSMETPPASP----MK 559

  Fly   440 KTTGTEQIDGANEKDSLPAVVEPT-TSSKPKPPHKRHILPSINVTTPSTFTTQIILAQATPTPTP 503
            ...|.:|...|.::       ||| .::.|.||                       |...|.|.|
  Fly   560 YNAGADQTPQALKE-------EPTYANALPAPP-----------------------AYTAPPPVP 594

  Fly   504 TA--------------EEMKLETHLSSISSASSSHSYASP----PQSPRIFQQSYERLTTKSILA 550
            .:              :.|.||..|..::..:..:...:|    .:.|.:.....|.|
  Fly   595 ISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTPLNLAVAPLSPISEKPSLLDLPQEML------- 652

  Fly   551 KSGHNHFGHQSDTNNYSIDGYLHGSSNASSYSSYSASMTSSSLVSSAQSNSSSIARRPAFE-SRA 614
                                            |.|:|.:::..||:|.||.|.......|| |||
  Fly   653 --------------------------------SRSSSTSNTRSVSAAVSNESVAGDSGVFEASRA 685

  Fly   615 RTKTDSLKHRQ-------------HSLGNSHN-----SESAEFQSIIERMASLGPNSQLSKGADE 661
            ......|...|             .||..::|     :.||:...:..| |:|.|||..|   ..
  Fly   686 HLPRKELAQVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLR-AALLPNSLTS---IR 746

  Fly   662 NLLLADYV------TWNGPNTKLLQKQITQGPNASLLTDRTYKPRGGKSELCKGPQSGLAK 716
            ...|.|:.      |:..|.|  |.|.:|:....:::|     ..|.|.|:....|..:|:
  Fly   747 TKALGDFQKPVFNDTFAVPIT--LDKLLTKSLQVTVVT-----MTGQKEEIIGTVQISMAE 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	12/52 (23%)
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809	14/29 (48%)
		C2_Kibra	693..813	CDD:176062	27/119 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR14791
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100