Protein Alignment CG10508 and WWC1

DIOPT Version :10

• Sequence 1: NP_001246859.1
• Gene: CG10508 / 40342
• FlyBaseID: FBgn0037060
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_011532787.1
• Gene: WWC1 / 23286
• HGNCID: 29435
• Length: 1185
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 149/797 - (18%)
• Similarity: 268/797 - (33%)
• Gaps: 219/797 - (27%)

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDPRGRSYRQLQNERCSTESIALQQLVSQPQTSHNS 73
            ::|.||:..||...|: |:|::.||..|:||||      :|..|.....:....:|:|...|...
Human    54 ELPLGWEEAYDPQVGD-YFIDHNTKTTQIEDPR------VQWRREQEHMLKDYLVVAQEALSAQK 111

  Fly    74 SPYHVHPSNNLTAIRAFQERQQPTLHNISTSPLL----SASSRGHLE-MSSPLPFQRARVGP--- 130
            ..|.|.......|.:.:|:......|.:.:...|    |:||:...| :.:.:...::||..
Human   112 EIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKR 176

  Fly   131 ---NLSRRSTIQETSFTTQAETDAVVTKIQNMFP------------------TAGENHIRLLLK- 173
               :|......:|..|.|..:.|..::..|..:.                  |.||...:.|:|
Human   177 EMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKS 241

  Fly   174 -----------RYYNSEAVVVSALQVEKHPVTMPGPFVTPPSQRHLFHSGSAFYMTPPARRPDTV 227
                       |..:|: :..|:..:|.....:|..::...||..:  ||| |.:....:..:.|
Human   242 LAMLKDGFRTDRGSHSD-LWSSSSSLESSSFPLPKQYLDVSSQTDI--SGS-FGINSNNQLAEKV 302

  Fly   228 ASRRTSRTASPLPGGRFGSLVSVQSGPGGPSGHQAV---LPPSSAVPPALH-------GSPLWRS 282
            ..|.....|.        ..:|.|.|...||..:..   ||.:|: ..|.|       ...|.|:
Human   303 RLRLRYEEAK--------RRLSCQCGQATPSNSELTHYQLPQASS-KTARHLYLDSHFLFSLKRT 358

  Fly   283 SPRPHSSPKMK---LRYMKNI---FPKADEELLLDILANADNNVQFASEKLISLGYTKRDMQQPH 341
            :....|.|..:   ||::.|:   ..|.|.|....:|.:..:.:...:||
Human   359 TLNLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEK--------------- 408

  Fly   342 RPNNRPPDLNQDQEAGGDQSGVHIPLRPKEYTEEEKTKMQTLLKEKYPQIAERIILMALESVNYA 406
                  .:|.::...          :.|:::|:.|                       :|.:..|
Human   409 ------EELLKEMRF----------ISPRKWTQGE-----------------------VEQLEMA 434

  Fly   407 EDRATQILQIVQDEDEQREQKQAPMNPKHLDLKKTTGTEQIDGANEKDSLPAVVEPTTSSKPKPP 471
            ..|..:.||..:|...:...::..:|.|...|.:    |..:...:..:|.:.::..:||
Human   435 RKRLEKDLQAARDTQSKALTERLKLNSKRNQLVR----ELEEATRQVATLHSQLKSLSSS----- 490

  Fly   472 HKRHILPSINVTTPSTFTTQIILAQATPTPTPTAEEMKLETHLSSISSASSSHSYASPPQSPRIF 536
                              .|.:.:.::|....::....:.:.|.|.:|||.:..|..|      |
Human   491 ------------------MQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDP------F 531

  Fly   537 QQSYERLTTK-SILAKSGHNHFG--------HQSD---TNNYSIDGYLHGSSNASSYSSYSASMT 589
            :|....|.:| ..|...|...|.        |:.:   |......|.|....:.|.......|::
Human   532 EQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLS 596

  Fly   590 SSSLVSSAQSNSSSIARRPAFESRARTKTDSLKHRQHSLGNSHNSESAEFQSIIERMASLGPNSQ 654
            ..|.:||.....|.:...|.....|             ..||...|..|..:.:..: |||.::|
Human   597 PRSSLSSPSPPCSPLMADPLLAGDA-------------FLNSLEFEDPELSATLCEL-SLGNSAQ 647

  Fly   655 LSKGADENLLLADYVTWNGPNTKLLQKQITQGPNASLLTDRTYKPRGGK--------SELCKGPQ 711
            .....:|            |.|:  .||:.|..|       |.:..|.|        |:......
Human   648 ERYRLEE------------PGTE--GKQLGQAVN-------TAQGCGLKVACVSAAVSDESVAGD 691

  Fly   712 SGLAKGSIYAQGSNKSA 728
            ||:.:.|:...|::::|
Human   692 SGVYEASVQRLGASEAA 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	8/41 (20%)
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	56..85	CDD:238122	13/29 (45%)
		C2_Kibra	721..844	CDD:176062