DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10508 and Wwc1

DIOPT Version :9

Sequence 1:	NP_001246859.1	Gene:	CG10508 / 40342	FlyBaseID:	FBgn0037060	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_740749.1	Gene:	Wwc1 / 211652	MGIID:	2388637	Length:	1104	Species:	Mus musculus

Alignment Length:	771	Identity:	147/771 - (19%)
Similarity:	235/771 - (30%)	Gaps:	249/771 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDPRGRSYRQLQNERCSTESIALQQLVSQPQTSHNS 73
            ::|.||:..||...|: |:|::.||..|:||||      :|..|.....:....:|:|...|...
Mouse    54 ELPLGWEEAYDPQVGD-YFIDHNTKTTQIEDPR------VQWRREQEHMLKDYLVVAQEALSAQK 111

  Fly    74 SPYHVHPSNNLTAIRAFQERQQPTLHNI-STSPLLSASSRGHLEMSSPLPFQRARVGPNLSRRST 137
            ..|.|.......|.:.:|:......|.: |...|:|.||            ..::..|.:.:...
Mouse   112 EIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSS------------SSSKYDPEILKAEI 164

  Fly   138 IQETSFTTQAETDAVVTKIQNMFPTAGENHIRLLLKRYYNSEAVVVSALQVEKHPVTMPGPFVTP 202
            ....|...:.:.:.|..:.:..|...|...::.:.:|..:::                 |.:...
Mouse   165 ATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQ-----------------GGYKLD 212

  Fly   203 PSQRHLFHSGSAFYMTPPARRPDTVASRRTSRTASPLPGGRFGSLVSVQSGPGGPSGHQAVLPPS 267
            .:|..|               .:|.|.::..............||..::.|.....|..
Mouse   213 EAQAVL---------------RETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSH------ 256

  Fly   268 SAVPPALHGSPLWRSSPRPHSSPKMKLRYMKNIFPKADEELLLDILANAD--------NNVQFAS 324
                     |.||.||....||.          ||...:  .||:.:..|        :|.|.|.
Mouse   257 ---------SDLWSSSSSLESSS----------FPMPKQ--FLDVSSQTDISGSFSTSSNNQLAE 300

  Fly   325 EKLISLGYTKRDMQQPHRPNNRPPDLNQDQEAGGDQSGVHIPLRPKEYTEEEKTKMQTLLKEKYP 389
            :..:.|.|                     :||             |......|.::..|..|.:|
Mouse   301 KVRLRLRY---------------------EEA-------------KRRIANLKIQLAKLDSEAWP 331

  Fly   390 QI----AERIILMALESVNYAEDRATQILQIVQDEDEQREQKQAPMNPKHLDLKKTTGTEQIDGA 450
            .:    .:|:||     :|..|:...::..|...:..|.|.:|..|..:.|:       :.:..|
Mouse   332 GVLDSERDRLIL-----INEKEELLKEMRFISPRKWTQGEVEQLEMARRRLE-------KDLQAA 384

  Fly   451 NEKDSLPAVVEPTTSSKPKPPHKRHILPSINVTTPSTFTTQII--LAQATPTPTPTAEEMKLETH 513
            .:..| .|:.|     :.|...||:               |::  |.:|      |.:...|.:.
Mouse   385 RDTQS-KALTE-----RLKLNSKRN---------------QLVRELEEA------TRQVATLHSQ 422

  Fly   514 LSSISSASSSHSYASPPQSPRIFQQSYERLTTKSILAKSGHNHFGHQSDTNNYSIDGYLHGSSNA 578
            |.|:||:..|.|..|.|.|          ||:.                          .||..|
Mouse   423 LKSLSSSMQSLSSGSSPGS----------LTSS--------------------------RGSLAA 451

  Fly   579 SSY-SSYSASMTS------SSLVSSAQSNSSSIARRPAFESR-----ARTKTDSLKHRQHSLGNS 631
            ||. ||.|||.|.      ..|.|..||....:....|...|     .....|.:...|.:.|.|
Mouse   452 SSLDSSTSASFTDLYYDPFEQLDSELQSKVELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGS 516

  Fly   632 HNSESAEFQSIIERMASLGPNSQLSKGA-------DENLLLAD------------------YVTW 671
            ..............|.||.|.|.||..:       .:.||..|                  .:..
Mouse   517 RLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDAFLAPLEFEDTELSTTLCELNL 581

  Fly   672 NGPNTKLLQKQITQGPNASLLTDRTYKPRGGKSELCKGPQSGLAKGSIYAQGSNKS 727
            .|..|:...:....||..        ||.|..:.:  .|..||....:.|..|::|
Mouse   582 GGSGTQERYRLEEPGPEG--------KPLGQAASV--APGCGLKVACVSAAVSDES 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	8/43 (19%)
Wwc1	NP_740749.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809	12/29 (41%)
		ALDH-SF	378..>420	CDD:299846	11/75 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..449		8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..547		10/37 (27%)
		C2_Kibra	661..784	CDD:176062
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..949
		Interaction with histone H3. /evidence=ECO:0000250	836..1104
		Interaction with PRKCZ. /evidence=ECO:0000250	945..988
		ADDV motif	1102..1104
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14791
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100