Protein Alignment CG10508 and wwc3

DIOPT Version :10

• Sequence 1: NP_001246859.1
• Gene: CG10508 / 40342
• FlyBaseID: FBgn0037060
• Length: 733
• Species: Drosophila melanogaster
• Sequence 2: XP_002932841.2
• Gene: wwc3 / 100127609
• XenbaseID: XB-GENE-5928407
• Length: 1196
• Species: Xenopus tropicalis
• Alignment Length: 740
• Identity: 141/740 - (19%)
• Similarity: 254/740 - (34%)
• Gaps: 219/740 - (29%)

  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDPRGRSYRQLQNERCSTESIALQQLVSQPQTSHNS 73
            ::|.||:...||..| .||::::.:..|:||||.:..|  :.||...|.:    :|:|...:...
 Frog    92 ELPLGWEIVRDQQIG-VYYMDHINQLTQVEDPREQWRR--EQERMLKEYL----VVAQEALNAKK 149

  Fly    74 SPYHVHPSNNLTAIRAFQERQQPTLHNISTSPLLSASSRGHLEMSSPL-------PFQ-RARVG- 129
            ..|.:.......|...||:     ||:     |....||.::...|..       |:| :|.:.
 Frog   150 EIYQIKQQRFELAQEEFQQ-----LHD-----LCEDDSRSYVSSFSGFSANTKYDPYQIKAEIAN 204

  Fly   130 -----PNLSRRSTIQETSFTTQAETDAVVTKIQNMFPTAGENHIRLLLKRYYNSEA-VVVSALQV 188
                 ..|.|..|:.:.....:.:....:.:|.....:|..|        |...|| .::|.|:.
 Frog   205 RRDRLSRLKRELTVMKQELQYKEKGVETLQEIDRKMSSAHTN--------YKLDEAQAIMSELRT 261

  Fly   189 EKHPVTMPGPFVTPPSQRHLFHSGSAFYMTPPARRPDTVAS-------RRTSRTASPLPG----- 241
            .:..:.|     ....:|.|..|.:.  :|...|....::.       ...|.|.|.||.
 Frog   262 LRQAICM-----GEKERRDLMQSLAK--LTDGFRNSCCISDSLYGAQHNSGSLTDSCLPQQYCDA 319

  Fly   242 -------GRFGSLVSVQSGPGGPSGHQAVLPPSSAVPPALHGSPLWRSSPRPHSSPKMKLRYMKN 299
                   |.||                  ....|.:...:..:..:..:.:..||.:.:|..:.|
 Frog   320 CSQTDNIGEFG------------------FDDKSRLADRVRLNWQYEEAKKRVSSIQHQLALLDN 366

  Fly   300 -IFPKADEELLLDILANAD-NNVQFASEKLISLGYTKRDMQQPHRPNNRPPDLNQDQEAGGDQSG 362
             .:|         ::|.|| :::|...||...|    :|:|...:....|.||::
 Frog   367 ETWP---------VMAEADRDHLQLIKEKEALL----QDLQLICQQRRSPEDLSR---------- 408

  Fly   363 VHIPLRPKEYTEEEKTKMQTLLKEKYPQ----IAERIILMALESVNYAEDRATQILQIVQDEDEQ 423
                      .|||..::...::..:..    |.||::|         :::...:|:.:
 Frog   409 ----------MEEEMRRLSDEIQRAHATSAQGITERLLL---------QEKRNSLLRCL------ 448

  Fly   424 REQKQAPMNPKHLDLKK-TTGTEQIDGANEKDSLPAVVEPTTSSKPKPPHKRHILPSINVT---- 483
             |:.....:..|..:|. :..|..:...:.:.||       .||:......|..|.||:.|
 Frog   449 -EEATRLASYLHTQIKSLSASTLTVSSGSSRGSL-------ASSRGSLASSRGSLSSISFTDIYG 505

  Fly   484 --------TPSTFTTQIIL-----------AQATPT---PTPTAEEMKLET--HLSSISSASSSH 524
                    |...:..|:..           .|.:.|   |....:::.::|  .|:|:||.||..
 Frog   506 LPHYEKAETQVEYGQQMRFDMIPLDALSKDCQYSETGGLPNLNKQKISMDTPQSLASLSSRSSLS 570

  Fly   525 SYASPPQSP---------------RIFQQSYERLTTKSI-------LAKSGHNHFGHQSDTNNY- 566
            | .|||.||               ::.:...|.::..|:       |.....|:.|..|.|..|
 Frog   571 S-LSPPSSPLDTPFLSASCDSPLTQMSEGLEEIMSIGSLDMIRGNSLTLGEENNQGTSSQTQGYN 634

  Fly   567 ------SIDGYLHGSSNASSYSSYSASMTS----SSLVSSAQSNSSSIARRPAFES---RARTKT 618
                  ::.|.|......|:.|......|:    :..||:..|:.|..:....||:   |.....
 Frog   635 TENKGKNLSGPLLSRLQMSAASPIQEVCTTRLQGACRVSAGLSDDSLTSDSGVFETLNKRNGNVD 699

  Fly   619 DSL-------KHRQHSLGNSHNSES 636
            ||:       :..|..:|..::|||
 Frog   700 DSVLKNSAKNEEPQVHVGIVYDSES 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10508	NP_001246859.1	CUE	291..327	CDD:270465	8/37 (22%)
wwc3	XP_002932841.2	WW	46..75	CDD:459800
		WW	93..122	CDD:459800	10/29 (34%)
		EnvC	181..>489	CDD:443969	63/396 (16%)
		DR0291	197..>285	CDD:441187	17/102 (17%)
		C2_Kibra	712..833	CDD:176062	5/13 (38%)