DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10512 and VF13D12L.3

DIOPT Version :9

Sequence 1:	NP_649289.2	Gene:	CG10512 / 40339	FlyBaseID:	FBgn0037057	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_496500.1	Gene:	VF13D12L.3 / 174795	WormBaseID:	WBGene00012149	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	193/414 - (46%)
Similarity:	256/414 - (61%)	Gaps:	18/414 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LQRCQLHLHVSGRHAAVLLSSKTTATTATSAVAAAQAPNAYANVGGFSITYRTMSAAAPKLVAVA 97
            |||.   |..:|.|.     |:..|..|.::|.        .|...:|.|...|:|....:||..
Worm     4 LQRA---LVFTGGHI-----SRYQAVIAVNSVG--------KNARFYSTTDDNMAAPEESVVAKD 52

  Fly    98 ESRRFMIDCFKAVKVPQAHAEAQADLLVAADHRGHFSHGMNRLEMYINDLAINSTDGAAVPKILK 162
            |.:|||::|...|...::||...|.:|:..|.|||:|||:|||:||:.|:..|...|...|.|||
Worm    53 EMKRFMVECMTKVGATESHATQLALVLLEGDIRGHYSHGLNRLDMYVRDIEQNVCKGDGEPIILK 117

  Fly   163 ETPATAWVDGLNGLGAVVGNYCMDLAIKKAKTVGVGWVCAKGSNHYGMAGWYAIRAMDQGLVGMS 227
            |...||||||.|.||.||||:||||||:|||..|:|||.||||||||:|||||:|||.:|::|||
Worm   118 EKAGTAWVDGNNLLGPVVGNFCMDLAIEKAKNAGIGWVVAKGSNHYGIAGWYALRAMKKGMLGMS 182

  Fly   228 MTNTSPLMAPTRAKEAALGTNPLSLGANATNGDKFLLDMATTAVAVGKIEIQRRKGAPLPDGWAQ 292
            ||||||:..|||:...||||||:||.|..|..|.|:||||:|.||:||:|:..||..|:|..|..
Worm   183 MTNTSPISFPTRSAVPALGTNPISLAAPGTGDDSFVLDMASTTVAIGKVELAARKENPVPLSWGV 247

  Fly   293 DPSGEVTNDAELGFSTGCLMPLGGSELTSGYKGYGLGAMVDILSGVMSGANYSTQVRKWTHAGAD 357
            ...|:.|.|.......|.|:||||.|::.|||||||.:|::|..|:::||::...||||  ....
Worm   248 GEGGKETTDPTKVLYGGGLLPLGGVEVSGGYKGYGLSSMIEIFCGILAGAHWGPHVRKW--MSTK 310

  Fly   358 SAADLGQVFIAVDPNCFAPNFEERMADFNSRLRGATPTDPSKPVLLAGDKEKKGMADVDAAGGIQ 422
            |.|||||.|:|:||..|||.|.:|:.||...:|....:.||..|.:|||.|::..|.|:..|||.
Worm   311 SEADLGQCFVAIDPEAFAPGFADRLQDFMQTMRALPTSSPSFKVEVAGDMERRHEALVEQLGGIP 375

  Fly   423 YLENQLKTCANLAEILKIKPLSFV 446
            |.:||:....:||..|.:|.:..|
Worm   376 YHKNQITFVNDLAAKLGVKTVDLV 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10512	NP_649289.2	PLN00105	100..432	CDD:215057	170/331 (51%)
CG10512	NP_649289.2	Ldh_2	100..408	CDD:280734	161/307 (52%)
VF13D12L.3	NP_496500.1	Ldh_2	53..379	CDD:280734	169/327 (52%)
VF13D12L.3	NP_496500.1	PLN00105	54..375	CDD:215057	166/322 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159222
Domainoid	1	1.000	351	1.000	Domainoid score	I534
eggNOG	1	0.900	-	-		E1_COG2055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14479
Inparanoid	1	1.050	364	1.000	Inparanoid score	I1264
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60886
OrthoDB	1	1.010	-	-		D1122265at2759
OrthoFinder	1	1.000	-	-		FOG0008534
OrthoInspector	1	1.000	-	-		otm14382
orthoMCL	1	0.900	-	-		OOG6_104354
Panther	1	1.100	-	-	LDO	PTHR11091
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16983
SonicParanoid	1	1.000	-	-		X11824
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800