DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment park and prkn

DIOPT Version :9

Sequence 1:	NP_730600.1	Gene:	park / 40336	FlyBaseID:	FBgn0041100	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001017635.1	Gene:	prkn / 550328	ZFINID:	ZDB-GENE-050417-109	Length:	458	Species:	Danio rerio

Alignment Length:	466	Identity:	207/466 - (44%)
Similarity:	277/466 - (59%)	Gaps:	27/466 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IYVKTNTGKTLTVNLEPQWDIKNVKELVAPQLGLQPDDLKIIFAGKELSDATTIEQCDLGQQSVL 96
            ::|:.|:.....|.||....:..:||.|....|:|.|.|::||||:||.:.:|::.|||.:||.:
Zfish     3 VFVRFNSSHGFPVELEQGASVSELKEAVGRLQGVQSDQLRVIFAGRELCNESTLQGCDLPEQSTV 67

  Fly    97 HAIRLRPP---------VQRQKIQSATLEEEEPSLSDEASKPLNETL-LDLQLESEERLNITDEE 151
            |.:  .||         :|::::.|.........||.......:|.| :.|:.|:..|.:.....
Zfish    68 HVV--LPPSTSAHRSELIQQRRLGSGMESLTRLDLSSSRQTTASEGLAVILETEASRREDTAGHT 130

  Fly   152 RVRAKAHFFVHC-SQCDKLCNGKLRVRCALCKGGAFTVHRDPECWDDVLKSRRIPGHCESLEVAC 215
            ..:|.:.|:|.| :.|..:..|||||||..||.|..|:.|.|.||||||...||.|.|:|  ..|
Zfish   131 GAKAHSSFYVFCKTVCKAIQPGKLRVRCKDCKQGTLTLSRGPSCWDDVLLPNRIHGVCQS--QGC 193

  Fly   216 VDNAAGDPPFAEFFFKCAEHVSGGEKDFAAPLNLIKNNIKNVPCLACTDVSDTVLVFPCASQHVT 280
                  :...|||:.|||.|.: .:.|.:..|:||..|.:.|||:||||:...||||.||.:||.
Zfish   194 ------NGRLAEFYLKCASHPT-CDNDTSVALDLIMPNTRRVPCIACTDIMTPVLVFQCAERHVI 251

  Fly   281 CIDCFRHYCRSRLGERQFMPHPDFGYTLPCPAGCEHSFIEEIHHFKLLTREEYDRYQRFATEEYV 345
            |::||..||.|||.||||......||:|||.|||..|.|:|:|||::|..|:|:||||:|.||.|
Zfish   252 CLECFHLYCVSRLNERQFTQETLLGYSLPCAAGCPDSLIKEVHHFRVLGEEQYERYQRYAAEECV 316

  Fly   346 LQAGGVLCPQPGCGMGLLVEPDCRKVTCQN-----GCGYVFCRNCLQGYHIGECLPEGTGASATN 405
            ||.||||||.||||.|||...:.|:|.|:.     |||:||||:|.:.:|.|.|....:.|||..
Zfish   317 LQMGGVLCPAPGCGAGLLPPDEERRVCCEPGNNGLGCGFVFCRDCKEEFHEGPCRHTTSTASAGA 381

  Fly   406 SCEYTVDPNRAAEARWDEASNVTIKVSTKPCPKCRTPTERDGGCMHMVCTRAGCGFEWCWVCQTE 470
            ...|.||...|..|||::||..||..:|.|||||:.|.|::||||||||.|..|.|||||:|:.|
Zfish   382 LQGYVVDEEAALRARWEQASQETITKTTHPCPKCQVPVEKNGGCMHMVCPRPQCKFEWCWLCRVE 446

  Fly   471 WTRDCMGAHWF 481
            |.|||||.|||
Zfish   447 WNRDCMGNHWF 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
park	NP_730600.1	UBQ	30..97	CDD:214563	24/64 (38%)
		parkin_N	32..101	CDD:176393	25/68 (37%)
		IBR	334..390	CDD:214763	34/60 (57%)
		IBR	<435..471	CDD:279784	23/35 (66%)
prkn	NP_001017635.1	UBQ	1..71	CDD:214563	25/69 (36%)
		parkin_N	3..70	CDD:176393	25/66 (38%)
		IBR	305..368	CDD:214763	35/62 (56%)
		IBR	<411..447	CDD:279784	23/35 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590041
Domainoid	1	1.000	122	1.000	Domainoid score	I5607
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3355
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1848
OMA	1	1.010	-	-		QHG46525
OrthoDB	1	1.010	-	-		D1140368at2759
OrthoFinder	1	1.000	-	-		FOG0006338
OrthoInspector	1	1.000	-	-		oto39182
orthoMCL	1	0.900	-	-		OOG6_108992
Panther	1	1.100	-	-	LDO	PTHR11685
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910