Protein Alignment park and PRKN

DIOPT Version :10

• Sequence 1: NP_730600.1
• Gene: park / 40336
• FlyBaseID: FBgn0041100
• Length: 482
• Species: Drosophila melanogaster
• Sequence 2: XP_016866397.1
• Gene: PRKN / 5071
• HGNCID: 8607
• Length: 503
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 203/479 - (42%)
• Similarity: 285/479 - (59%)
• Gaps: 39/479 - (8%)

  Fly    28 HTLSIYVKTNTGKTLTVNLEPQWDIKNVKELVAPQLGLQPDDLKIIFAGKELSDATTIEQCDLGQ 92
            :.::::|:.|:.....|.::....|..:||:||.:.|:..|.|::|||||||.:..|::.|||.|
Human    37 YPITVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQ 101

  Fly    93 QSVLHAIRLRPPVQRQKIQSATLEEEEPSLSDEASKPLNETLLDLQ--------------LESEE 143
            ||::|.:: ||..:.|::.:...::...:......:|.:.|.:||.              |.::.
Human   102 QSIVHIVQ-RPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDS 165

  Fly   144 RLNITDEERVRAKA------HFFVHC-SQCDKLCNGKLRVRCALCKGGAFTVHRDPECWDDVLKS 201
            |   .|.....:.|      .|:|:| ..|.::..|||||:|:.|:....|:.:.|.||||||..
Human   166 R---KDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIP 227

  Fly   202 RRIPGHCESLEVACVDNAAGDPPFAEFFFKCAEHVSGGEKDFAAPLNLIKNNIKNVPCLACTDVS 266
            .|:.|.|:|..  |...:      |||||||..|.: .:|:.:..|:||..|.:|:.|:.||||.
Human   228 NRMSGECQSPH--CPGTS------AEFFFKCGAHPT-SDKETSVALHLIATNSRNITCITCTDVR 283

  Fly   267 DTVLVFPCASQHVTCIDCFRHYCRSRLGERQFMPHPDFGYTLPCPAGCEHSFIEEIHHFKLLTRE 331
            ..||||.|.|:||.|:|||..||.:||.:|||:..|..||:|||.|||.:|.|:|:|||::|..|
Human   284 SPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEE 348

  Fly   332 EYDRYQRFATEEYVLQAGGVLCPQPGCGMGLLVEPDCRKVTCQN----GCGYVFCRNCLQGYHIG 392
            :|:|||::..||.|||.||||||:||||.|||.|||.|||||:.    |||:.|||.|.:.||.|
Human   349 QYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEG 413

  Fly   393 ECLPEGTGASATNSCEYTVDPNRAAEARWDEASNVTIKVSTKPCPKCRTPTERDGGCMHMVCTRA 457
            || .....||.|.:..|.||...|.:|||:.||..|||.:|||||:|..|.|::||||||.|.:.
Human   414 EC-SAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQP 477

  Fly   458 GCGFEWCWVCQTEWTRDCMGAHWF 481
            .|..||||.|..||.|.|||.|||
Human   478 QCRLEWCWNCGCEWNRVCMGDHWF 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
park	NP_730600.1	Ubl_parkin	32..105	CDD:340496	28/72 (39%)
		RING0_parkin	159..250	CDD:412057	34/91 (37%)
		zf-RING_14	249..337	CDD:465601	47/87 (54%)
		BRcat_RBR_parkin	322..398	CDD:439001	47/79 (59%)
		Rcat_RBR_parkin	428..481	CDD:439018	31/52 (60%)
PRKN	XP_016866397.1	Ubl_parkin	41..114	CDD:340496	28/73 (38%)
		RING0_parkin	184..267	CDD:412057	34/91 (37%)
		zf-RING_14	266..354	CDD:465601	47/87 (54%)
		BRcat_RBR_parkin	339..417	CDD:439001	47/78 (60%)
		Rcat_RBR_parkin	447..501	CDD:439018	31/53 (58%)